Adverse childhood experiences and lifelong health

Nature Medicine, Год журнала: 2023, Номер 29(7), С. 1639 - 1648

Опубликована: Июль 1, 2023

Язык: Английский

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Annual Research Review: Rethinking childhood trauma‐new research directions for measurement, study design and analytical strategies

Journal of Child Psychology and Psychiatry, Год журнала: 2019, Номер 61(3), С. 236 - 250

Опубликована: Ноя. 24, 2019

Childhood trauma is a key modifiable risk factor for psychopathology. Despite significant scientific advances, traumatised children still have poorer long‐term outcomes than nontraumatised children. New research paradigms are, thus, needed. To this end, the review examines three dominant assumptions about measurement, design and analytical strategies. Current warns against using prospective retrospective measures of childhood interchangeably; interpreting cross‐sectional differences in putative mediating mechanisms between adults with or without history as evidence longitudinal changes from pre‐trauma conditions; directly applying explanatory models resilience vulnerability to psychopathology forecast individual unseen cases. The warnings equally apply on broader adverse experiences (ACEs). Further examining these can generate new insights how prevent its detrimental effects.

Язык: Английский

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Childhood Trauma in Adult Depressive and Anxiety Disorders: An Integrated Review on Psychological and Biological Mechanisms in the NESDA Cohort

Journal of Affective Disorders, Год журнала: 2021, Номер 283, С. 179 - 191

Опубликована: Янв. 28, 2021

Childhood trauma (CT) has adverse consequences on mental health across the lifespan. The understanding of how CT increases vulnerability for psychiatric disorders is growing. However, lack an integrative approach to psychological and biological mechanisms hampers further advancement. This review integrates findings explanatory levels from a longitudinal adult cohort – Netherlands Study Depression Anxiety (NESDA). We reviewed all studies (k = 37) NESDA (n 2981) published 2009 2020 containing related psychopathology potential CT. was associated with higher risk anxiety depressive strongest associations in comorbid group. predicted onset these disorders, recurrence, poorer outcomes (more comorbidity chronicity). maladaptive personality characteristics cognitions (e.g., neuroticism negative self-associations), mild stress systems dysregulations (heightened cortisol inflammation), advanced aging (increased epigenetic telomere attrition), lifestyle (higher smoking rate body mass index), somatic decline increased metabolic syndrome dysregulations), brain alterations reduced mPFC volume amygdala reactivity). Literature one using mixed analytical approaches. : impacts functioning brain, mind, body, which together may contribute affective disorders. It essential employ combining different sources data understand better.

Язык: Английский

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Life stress and cortisol reactivity: An exploratory analysis of the effects of stress exposure across life on HPA-axis functioning

Development and Psychopathology, Год журнала: 2020, Номер 33(1), С. 301 - 312

Опубликована: Март 3, 2020

Abstract Stressful experiences affect biological stress systems, such as the hypothalamic–pituitary–adrenal (HPA) axis. Life can potentially alter regulation of HPA axis and has been associated with poorer physical mental health. Little, however, is known about relative influence stressors that are encountered at different developmental periods on acute reactions in adulthood. In this study, we explored three models exposure cortisol reactivity to a modified version Trier Social Stress Test (TSST) by leveraging 37 years longitudinal data high-risk birth cohort (N = 112). The cumulative model suggests accumulated across lifespan leads dysregulated reactivity, whereas embedding implicates early childhood critical period. sensitization assumes dysregulation should only occur when high both concurrently. All predicted altered but do not anticipate its exact form. We found support for effects. However, pitted against each other, life more blunted responses age over above stress. Additional analyses revealed middle also reactivity.

Язык: Английский

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“It made me feel brighter in myself”- The health and well-being impacts of a residential front garden horticultural intervention

Landscape and Urban Planning, Год журнала: 2020, Номер 205, С. 103958 - 103958

Опубликована: Сен. 30, 2020

Язык: Английский

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Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects

Neuroscience & Biobehavioral Reviews, Год журнала: 2022, Номер 135, С. 104589 - 104589

Опубликована: Фев. 18, 2022

Язык: Английский

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Adverse childhood experiences: A scoping review of measures and methods

Children and Youth Services Review, Год журнала: 2022, Номер 136, С. 106425 - 106425

Опубликована: Фев. 21, 2022

Язык: Английский

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From childhood adversity to latent stress vulnerability in adulthood: the mediating roles of sleep disturbances and HPA axis dysfunction

Neuropsychopharmacology, Год журнала: 2023, Номер 48(10), С. 1425 - 1435

Опубликована: Июнь 30, 2023

Язык: Английский

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Stress before conception and during pregnancy and maternal cortisol during pregnancy: A scoping review

Psychoneuroendocrinology, Год журнала: 2023, Номер 153, С. 106115 - 106115

Опубликована: Апрель 18, 2023

Stress before conception and during pregnancy is associated with less favorable maternal child health. Alterations in prenatal cortisol levels may serve as a central biological pathway linking stress to adverse Research examining associations between from childhood through has not been comprehensively reviewed.

Язык: Английский

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Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: A conceptual model for the study of sex and gender differences

Frontiers in Neuroendocrinology, Год журнала: 2024, Номер 73, С. 101121 - 101121

Опубликована: Янв. 20, 2024

Язык: Английский

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