Glucocorticoid Receptor Gene (NR3C1) Methylation Childhood Maltreatment Multilevel Reward Responsiveness and Depressive and Anxiety Symptoms: A Neuroimaging Epigenetic Study

NeuroImage, Год журнала: 2025, Номер 306, С. 121003 - 121003

Опубликована: Янв. 7, 2025

Although epigenomic and environment interactions (Epigenome × Environment; Epi E) might constitute a novel mechanism underlying reward processing direct evidence is still scarce. We conducted the first longitudinal study to investigate extent which DNA methylation of stress-related gene-NR3C1-interacts with childhood maltreatment in association young adult responsiveness (RR) downstream risk depressive (anhedonia dimension particular) anxiety symptoms. A total 192 Chinese university students aged 18∼25 (M NR3C1-1F significantly interacted on RewP but not delta theta components or self-reported RR. The severity exposure number were negatively associated among individuals heightened positively blunted demonstrating "goodness-of-fit" interaction. This interaction was specifically linked anhedonia scores current findings provide preliminary for an E highlight cross-level analyses electrophysiological signals advance knowledge biological foundation stress-induced function relevant However caution should be paid generalizability these high-risk clinical samples given high-functioning characteristic present sample.

Язык: Английский

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Victimization and Its Consequences over the Life Course

Crime and Justice, Год журнала: 2023, Номер 52, С. 265 - 342

Опубликована: Авг. 30, 2023

One of the broadest and most interdisciplinary areas research concerns victimization its developmental consequences. Although a wealth literature has been produced, it remains siloed across multiple fields, including criminology, sociology, psychology, education, social work, public health, with such work rarely crossing disciplinary boundaries. The fragmentation scholarship along lines makes difficult to recognize common findings or solve shared theoretical, methodological, policy problems. To remedy these issues, multidisciplinary on sources consequences should be synthesized through lens life-course paradigm couched within ecological framework. Across early life, childhood, adolescence, emerging adulthood, adulthood midlife, old age, are multilevel complex. Some stages life course more understudied than others, is not immune from measurement spuriousness selection, unexplained variation. And while conceptual methodological challenges remain, theory can enhanced embracing victimology. Research advance by unifying opportunity vulnerability perspectives context-contingent approach, emphasizing age-graded changes in autonomy over span placing focus heterogeneity individuals, stages, generational cohorts.

Язык: Английский

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“Helping Me Get Through the Day”: The Importance of Social Contact and Support for Incarcerated Young People During the COVID-19 Pandemic

Journal of Forensic Social Work, Год журнала: 2024, Номер 8(1), С. 13 - 33

Опубликована: Авг. 7, 2024

Background: There is limited knowledge about how incarcerated young people have been affected by the COVID-19 pandemic. An improved understanding of impact pandemic circumstances could help to advance a multitude practices and policies, including those that strengthen personal relationships. Objectives: This study aimed (a) describe self-reported perceptions social contact support for are powerful protective factors with potential attenuate negative impacts incarceration, (b) explore on their relational well-being, (c) determine extent which restricted access other resources, (d) consider identity-related differences in these impacts. Methods: exploratory employed interpretative phenomenological analysis (Smith et al., 2010) semi-structured interviews 30 youth an adult correctional setting, ages 16-21 years, addition some preliminary information multidimensional support. Results: Significant benefits family were identified, such as moral guidance, hopefulness, goal maintenance, well necessity relationships well-being given especially challenging created Limitations barriers support, services, identified may implications programmatic system-level changes. Conclusion: Contact involvement supportive important people, perhaps so during times crisis. Specific both forensic work practice, family-focused advocacy further qualitative research, explored.

Язык: Английский

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In the face of ambiguity: intrinsic brain organization in development predicts one’s bias toward positivity or negativity

Cerebral Cortex, Год журнала: 2024, Номер 34(3)

Опубликована: Март 1, 2024

Abstract Exacerbated negativity bias, including in responses to ambiguity, represents a common phenotype of internalizing disorders. Individuals differ their propensity toward positive or negative appraisals ambiguity. This variability constitutes one’s valence stable construct linked mental health. Evidence suggests an initial response ambiguity that updates via regulatory processes support more bias. Previous work implicates the amygdala and prefrontal cortex, regions cingulo-opercular system, this process. Nonetheless, neurodevelopmental origins bias remain unclear. The current study tests whether intrinsic brain organization predicts among 119 children adolescents (6 17 years). Using whole-brain resting-state functional connectivity, machine-learning model predicted (r = 0.20, P 0.03), as did restricted system features 0.19, 0.04). Disrupting connectivity revealed additional intra-system (e.g. fronto-parietal) inter-system cingulo-opercular) important for prediction. results highlight top–down control systems bottom–up perceptual influence development. Thus, informs directs future aimed at explicating related symptomology.

Язык: Английский

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Early life adversity is associated with greater similarity in neural representations of ambiguous and threatening stimuli

Development and Psychopathology, Год журнала: 2024, Номер unknown, С. 1 - 13

Опубликована: Апрель 11, 2024

Abstract Exposure to early life adversity (ELA) is hypothesized sensitize threat-responsive neural circuitry. This may lead individuals overestimate threat in the face of ambiguity, a cognitive-behavioral phenotype linked poor mental health. The tendency process ambiguity as threatening stem from difficulty distinguishing between ambiguous and stimuli. However, it unknown how exposure ELA relates representations stimuli, or processing following psychosocial functioning. current fMRI study examined multivariate social cues 41 emerging adults (aged 18 19 years). Using representational similarity analysis, we assessed images within affective circuitry tested whether these varied by exposure. Greater was associated with greater images. Moreover, individual differences related global functioning, an association that function ELA. By evidencing reduced differentiation ELA-exposed linking behavioral responses wellbeing, findings have important implications for future intervention work at-risk, populations.

Язык: Английский

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Decoding Adolescent Decision Making: Neurocognitive Processes, Risk Perception, and the Influence of Peers

Adolescents, Год журнала: 2024, Номер 4(2), С. 222 - 225

Опубликована: Апрель 30, 2024

Investigating the neurocognitive mechanisms behind implicit risk assessment and decision making in adolescents is crucial for understanding intricate array of behaviors typical this developmental phase [...]

Язык: Английский

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Neural representations of ambiguous affective stimuli and resilience to anxiety in emerging adults

Biological Psychology, Год журнала: 2023, Номер 182, С. 108624 - 108624

Опубликована: Июнь 30, 2023

The tendency to interpret ambiguous stimuli as threatening has been associated with a range of anxiety disorders. Responses ambiguity may be particularly relevant mental health during the transition from adolescence adulthood ("emerging adulthood"), when individuals encounter unfamiliar challenges and navigate novel social situations. However, it remains unclear whether neural representations relate risk for anxiety. present study sought examine multivariate - their similarity threat appraisals or in sample emerging adults. Participants (N = 41) viewed (angry), nonthreatening (happy), (surprised) facial while undergoing fMRI. Outside scanner, participants were presented same categorized faces positive negative. Using representational analyses (RSA), we investigated degree pattern responses ambiguous, nonthreatening, within amygdala related symptomatology. We found that who evidenced greater (i.e., less differentiation) left reported lower concurrent Additionally, trial-level predicted subsequent stimuli. These findings provide insight into how resilience development

Язык: Английский

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Emotion Regulation in Couples Across Adulthood

Annual Review of Developmental Psychology, Год журнала: 2023, Номер 5(1), С. 399 - 421

Опубликована: Дек. 11, 2023

Intimate relationships are hotbeds of emotion. This article presents key findings and current directions in research on couples’ emotion regulation across adulthood as a critical context which older adults not only maintain functioning but may also outshine younger adults. First, I introduce concepts, defining qualities (i.e., dynamic, coregulatory, bidirectional, bivalent), measures self-report versus performance-based) regulation. Second, highlight socioemotional turn our understanding adult development with the advent selectivity theory. Third, offer life-span developmental perspective couples infancy, adolescence young adulthood, midlife, late life). Finally, present idea that shift from “me to us” discuss how become more important, better, increasingly consequential (e.g., for relationship outcomes, well-being, health) age. Ideas future then discussed.

Язык: Английский

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Linking social reward responsiveness and affective responses to the social environment: An ecological momentary assessment study

Psychophysiology, Год журнала: 2024, Номер 61(10)

Опубликована: Июль 4, 2024

Social support is a key predictor of well-being, but not everyone experiences mental health benefits from receiving it. However, given that growing number interventions are based on social support, it crucial to identify the features make individuals more likely benefit ties. Emerging evidence suggests neural responses positive feedback (i.e., reward) might relate individual differences in functioning, potential mechanisms linking these psychological outcomes yet unclear. This study examined whether correlates reward processing, indexed by positivity (RewP), individuals' affective experience following self-reported real-world events. To this aim, 193 university students (71% females) underwent an EEG assessment during Island Getaway task and completed 10-day ecological momentary where participants reported their negative affects (PA, NA) nine times day count daily Experiencing higher events was associated with PA. The RewP moderated association, such greater response at baseline had stronger association between Individual be one indicator likelihood experiencing affect when support.

Язык: Английский

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Suporte social, saúde e uso de álcool e tabaco em pessoas com câncer

Опубликована: Март 11, 2024

Introdução: O câncer é um problema de saúde coletiva, os índices são crescentes nos últimos anos, sendo que muitos podem estar relacionados a fatores estilos vida, como o uso álcool e/ou tabaco.O suporte social uma ferramenta importante visa fornecer recursos e conforto durante períodos necessidade ou dificuldade, incluindo pessoas com câncer, amenizando as dificuldades sofrimento psíquico favorecendo mudanças comportamentos, contribuindo para sentido mais profundo pertencimento bem estar.O presente estudo faz parte projeto matricial intitulado "Câncer seus associados: análise registro base populacional hospitalar

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