Development and early life stress sensitivity of the rat cortical microstructural similarity network DOI Creative Commons
Rachel L. Smith, Stephen J. Sawiak, Lena Dorfschmidt

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 21, 2024

The rat offers a uniquely valuable animal model in neuroscience, but we currently lack an individual-level understanding of the vivo brain network. Here, leveraging longitudinal measures cortical magnetization transfer ratio (MTR) from neuroimaging between postnatal days 20 (weanling) and 290 (mid-adulthood), design implement computational pipeline that captures network structural similarity (MIND, morphometric inverse divergence) each 53 distinct areas. We first characterized normative development cohort rats undergoing typical (N=47), then contrasted these findings with exposed to early life stress (ELS, N=40). MIND as metric connectivity was validated by cytoarchitectonics axonal tract-tracing data. had high between-study reliability complex topological properties including rich club. Similarity changed during post-natal adolescent development, phase fronto-hippocampal convergence, or increasing inter-areal similarity. An process dissimilarity seen post-adult aging. Exposure ELS form maternal separation appeared accelerate trajectory - highlighting embedding dynamic Our work provides novel tools for systems-level study can now be used understand network-based underpinnings lifespan behaviors experimental manipulations this organism allows. Network models derived have revolutionized our human need translation into interrogate their underlying mechanisms. Rats provide due biological similarities humans; however, networks remain underdeveloped. In study, present construct such highlight experiential sensitivity systems rats, offering reference cross-species comparisons mechanistic insights architecture. To support broader research efforts, include open release code data analysis.

Язык: Английский

The influence of childhood trauma on social media-induced secondary traumatic stress among college students: the chain mediating effect of self-compassion and resilience DOI Creative Commons
Xiqin Liu,

Ye Yao,

Siyu Zhu

и другие.

European journal of psychotraumatology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 3, 2025

Background: Studies have shown that media exposure to critical public events can lead secondary traumatic stress (STS). Personal trauma history, self-compassion and resilience are important factors influencing STS in healthy professionals. However, whether these variables associated with social media-induced college students the underlying mechanisms remain unclear. The purpose of this study was explore complex relationship linking childhood a large sample students.

Язык: Английский

Процитировано

0

Resting-state network alterations in depression: a comprehensive meta-analysis of functional connectivity DOI
Zhihui Zhang, Yijing Zhang, He Wang

и другие.

Psychological Medicine, Год журнала: 2025, Номер 55

Опубликована: Янв. 1, 2025

Abstract Background Depression has been linked to disruptions in resting-state networks (RSNs). However, inconsistent findings on RSN disruptions, with variations reported connectivity within and between RSNs, complicate the understanding of neurobiological mechanisms underlying depression. Methods A systematic literature search PubMed Web Science identified studies that employed functional magnetic resonance imaging (fMRI) explore changes Studies using seed-based analysis or independent component were included, coordinate-based meta-analyses performed evaluate alterations both networks. Results total 58 comprising 2321 patients depression 2197 healthy controls. The meta-analysis revealed significant connectivity, networks, compared Specifically, within-network included increased decreased default mode network (DMN) frontoparietal (FPN). Between-network showed DMN–FPN limbic (LN)–DMN DMN–somatomotor LN–FPN varied ventral attention (VAN)–dorsal attentional (DAN) connectivity. Additionally, a positive correlation was found illness duration VAN DAN. Conclusions These not only provide comprehensive characterization but also enhance our

Язык: Английский

Процитировано

0

Gray matter atrophy in the middle frontal gyrus mediates post-traumatic stress symptoms in post-kidney transplant patients: The role of elevated urea levels DOI Creative Commons
Xinyi Zhu, Xinyi Wang, Shan Wu

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

The mediation role of gray matter volume in the relationship between childhood maltreatment and psychological resilience in adolescents with first-episode major depressive disorder DOI Creative Commons
Hui Chen,

Peiqu Liu,

Xianliang Chen

и другие.

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 24, 2024

Previous studies have revealed morphologic alterations in patients with major depressive disorder (MDD) experiences of childhood trauma. However, the underlying neural mechanisms remain largely unknown. This study aims to explore brain structural changes and their possible mediation role relationship between maltreatment psychological resilience drug-naïve adolescents first-episode MDD. A total 57 MDD 36 healthy controls (HCs) completed T1-weighted magnetic resonance imaging scan. The adverse current were assessed using Childhood Trauma Questionnaire-Short Form Connor Davidson Resilience Scale, respectively. voxel-based morphometry approach was applied examine gray matter volume (GMV). Compared HCs, had significantly reduced GMV volumes left fusiform gyrus, right orbitofrontal superior temporal calcarine cortex, middle frontal angular precuneus, posterior cingulate central as well increased lenticular putamen pallidum. cortex found be negatively correlated severity emotional abuse positively level resilience. Moreover, might partially mediate present provided further evidence for impairments Our findings also confirmed important depression-related growth characteristics during adolescent maturation.

Язык: Английский

Процитировано

1

Development and early life stress sensitivity of the rat cortical microstructural similarity network DOI Creative Commons
Rachel L. Smith, Stephen J. Sawiak, Lena Dorfschmidt

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 21, 2024

The rat offers a uniquely valuable animal model in neuroscience, but we currently lack an individual-level understanding of the vivo brain network. Here, leveraging longitudinal measures cortical magnetization transfer ratio (MTR) from neuroimaging between postnatal days 20 (weanling) and 290 (mid-adulthood), design implement computational pipeline that captures network structural similarity (MIND, morphometric inverse divergence) each 53 distinct areas. We first characterized normative development cohort rats undergoing typical (N=47), then contrasted these findings with exposed to early life stress (ELS, N=40). MIND as metric connectivity was validated by cytoarchitectonics axonal tract-tracing data. had high between-study reliability complex topological properties including rich club. Similarity changed during post-natal adolescent development, phase fronto-hippocampal convergence, or increasing inter-areal similarity. An process dissimilarity seen post-adult aging. Exposure ELS form maternal separation appeared accelerate trajectory - highlighting embedding dynamic Our work provides novel tools for systems-level study can now be used understand network-based underpinnings lifespan behaviors experimental manipulations this organism allows. Network models derived have revolutionized our human need translation into interrogate their underlying mechanisms. Rats provide due biological similarities humans; however, networks remain underdeveloped. In study, present construct such highlight experiential sensitivity systems rats, offering reference cross-species comparisons mechanistic insights architecture. To support broader research efforts, include open release code data analysis.

Язык: Английский

Процитировано

0