IL-27 as a novel biomarker for pruritus in nodular prurigo and bullous pemphigoid DOI Creative Commons
Yifei Wang, Xin Zhang, Yue Teng

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Дек. 13, 2024

Introduction Bullous pemphigoid (BP) and prurigo nodularis (PN) are chronic pruritic skin diseases that severely impact patients’ quality of life. Despite the widespread attention these two have garnered within dermatological field, specific pathogenesis, particularly molecular mechanisms underlying pruritus, remains largely unclear. Limited clinical sequencing studies focusing on BP PN hindered identification pathological exploration effective treatment strategies. Methods To address this gap, we collected a total 23 peripheral blood mononuclear cell samples from patients, as well healthy controls, performed RNA analysis. By integrating bioinformatics machine learning techniques, aimed to uncover shared immune regulatory networks pruritus-related between PN. Results Our study identified 161 differentially expressed genes PN, which were primarily enriched in activation neural pathways, providing crucial insights into both diseases. Furthermore, using algorithms support vector machines random forest, pinpoint 7 databases. Among these, IL-27 emerged potential pivotal gene, its mRNA expression levels strongly correlated with parameters including pruritus scores, immunoglobulin E levels, eosinophil counts. Validation experiments conducted an additional 22 participants confirmed upregulation lesions. Discussion This is first unveil inflammatory pathways common highlighting critical role pathogenesis conditions. findings not only enhance understanding intricate relationship but also provide foundation for development novel therapeutic strategies targeting

Язык: Английский

No allergy, but mast cells are involved: MRGPRX2 in chronic inflammatory skin diseases DOI Creative Commons
Martin Metz

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2025, Номер 39(3), С. 451 - 452

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

0
Histamine H3 and H4 Receptor Antagonists Differentially Inhibit Mast Cell Activation via FcεRI and MRGPRX2 Pathways DOI
Yuxin Zhang, Jiahua Guo, Dan Ye

и другие.

Clinical & Experimental Allergy, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Язык: Английский

Процитировано

0
Psychological Stress and Urticaria: Pathophysiologic and Therapeutic Updates DOI Creative Commons
Yi‐Kui Xiang, Murat Türk, Iván Chérrez-Ojeda

и другие.

Current Treatment Options in Allergy, Год журнала: 2024, Номер unknown

Опубликована: Сен. 20, 2024

Язык: Английский

Процитировано

2
Role of Platelet-Activating Factor in the Pathogenesis of Chronic Spontaneous Urticaria DOI Open Access
Bo Youn Choi, Young‐Min Ye

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(22), С. 12143 - 12143

Опубликована: Ноя. 12, 2024

Chronic spontaneous urticaria (CSU) is a debilitating condition characterized by mast cell activation. Platelet-activating factor (PAF) produced various immune cells, including basophils, lymphocytes, and eosinophils, which play crucial roles in CSU pathogenesis. It induces degranulation, increases vascular permeability, promotes the chemotaxis of inflammatory cells. These effects result release mediators, development edema, persistence inflammation, are key features CSU. Notably, elevated PAF levels have been linked to heightened disease activity resistance antihistamine treatment patients. Despite these findings, precise role pathogenesis remains unclear. Rupatadine, an antihistamine, heat shock protein 10, natural anti-inflammatory peptide that selectively inhibits PAF-induced demonstrated anti-PAF activity. Furthermore, with molecular structure receptor now identified, several experimental antagonists synthesized. However, there significant need for therapeutic options targeting management.

Язык: Английский

Процитировано

1
IL-27 as a novel biomarker for pruritus in nodular prurigo and bullous pemphigoid DOI Creative Commons
Yifei Wang, Xin Zhang, Yue Teng

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Дек. 13, 2024

Introduction Bullous pemphigoid (BP) and prurigo nodularis (PN) are chronic pruritic skin diseases that severely impact patients’ quality of life. Despite the widespread attention these two have garnered within dermatological field, specific pathogenesis, particularly molecular mechanisms underlying pruritus, remains largely unclear. Limited clinical sequencing studies focusing on BP PN hindered identification pathological exploration effective treatment strategies. Methods To address this gap, we collected a total 23 peripheral blood mononuclear cell samples from patients, as well healthy controls, performed RNA analysis. By integrating bioinformatics machine learning techniques, aimed to uncover shared immune regulatory networks pruritus-related between PN. Results Our study identified 161 differentially expressed genes PN, which were primarily enriched in activation neural pathways, providing crucial insights into both diseases. Furthermore, using algorithms support vector machines random forest, pinpoint 7 databases. Among these, IL-27 emerged potential pivotal gene, its mRNA expression levels strongly correlated with parameters including pruritus scores, immunoglobulin E levels, eosinophil counts. Validation experiments conducted an additional 22 participants confirmed upregulation lesions. Discussion This is first unveil inflammatory pathways common highlighting critical role pathogenesis conditions. findings not only enhance understanding intricate relationship but also provide foundation for development novel therapeutic strategies targeting

Язык: Английский

Процитировано

1