In Silico Design of Natural Inhibitors of ApoE4 from the Plant Moringa oleifera: Molecular Docking and Ab Initio Fragment Molecular Orbital Calculations DOI Creative Commons
Divya Shaji,

Yoshinobu Nagura,

Haruna Sabishiro

и другие.

Molecules, Год журнала: 2023, Номер 28(24), С. 8035 - 8035

Опубликована: Дек. 11, 2023

Alzheimer's disease (AD) is a neurological disease, and its signs symptoms appear slowly over time. Although current treatments can alleviate symptoms, they cannot prevent the from progressing. To accurately diagnose treat it therefore necessary to establish effective methods for diagnosis. Apolipoprotein E4 (ApoE4), most frequent genetic risk factor AD, expressed in more than half of patients with making an attractive target AD therapy. We used molecular docking simulations, classical mechanics optimizations, ab initio fragment orbital (FMO) calculations investigate specific interactions between ApoE4 naturally occurring compounds found plant Moringa Oleifera. According FMO calculations, quercetin had highest binding affinity among sixteen because hydroxyl groups generated strong hydrogen bonds residues Trp11, Asp12, Arg15, Asp130. As result, we proposed various derivatives by introducing group into studied their properties. The data clearly showed that adding improved capacity ApoE4. Furthermore, Asp130 were discovered be required significant derivatives. They higher our previously epicatechin Accordingly, results evaluated using method will useful designing potent inhibitors as candidate agent treatment.

Язык: Английский

Nrf2: A Main Responsive Element of the Toxicity Effect Caused by Trichothecene (T-2) Mycotoxin DOI Creative Commons

Youshuang Wang,

Yu Liu,

Tingyu Huang

и другие.

Toxics, Год журнала: 2023, Номер 11(4), С. 393 - 393

Опубликована: Апрель 21, 2023

T-2 toxin, the most toxic type A trichothecene mycotoxin, is produced by Fusarium, and widely found in contaminated feed stored grains. toxin physicochemically stable challenging to eradicate from cereal, resulting food contamination that inescapable poses a major hazard both human animal health, according World Health Organization. Oxidative stress upstream cause of all pathogenic variables, primary mechanism through which causes poisoning. Nuclear factor E2-related 2 (Nrf2) also plays crucial part oxidative stress, iron metabolism mitochondrial homeostasis. The ideas emerging trends future study are comprehensively discussed this review, along with research progress molecular Nrf2’s involvement toxicity impact brought on toxin. This paper could provide theoretical foundation for elucidating how Nrf2 reduces damage caused reference exploring target drugs alleviate molecules.

Язык: Английский

Процитировано

9
Formulation and Physical–Chemical Analysis of Functional Muffin Made with Inulin, Moringa, and Cacao Adapted for Elderly People with Parkinson’s Disease DOI Creative Commons
Paula García Milla, Rocío Peñalver, Gema Nieto

и другие.

Antioxidants, Год журнала: 2024, Номер 13(6), С. 683 - 683

Опубликована: Май 31, 2024

Parkinson's disease (PD) is a neurodegenerative disorder that affects people's health. Constipation probably one of the most prominent gastrointestinal symptoms (non-motor symptoms) PD with devastating consequences. The aim this research work to formulate functional food product, supplemented inulin, cocoa, and Moringa, which can be an adjuvant in treatment constipation. product was prepared according muffin or "Chilean cake" recipe; basic additions inulin (MI), + cacao (MIC), Moringa (MIM). A physical-chemical analysis macronutrients antioxidant capacity assessment samples were conducted, as well sensory evaluation performed by group people suffering from disease. statistically significant difference observed soluble (

Язык: Английский

Процитировано

2
Moringa oleifera Lam Leaf Extract Stimulates NRF2 and Attenuates ARV-Induced Toxicity in Human Liver Cells (HepG2) DOI Creative Commons
Siqiniseko S. Ndlovu, Anil A. Chuturgoon, Terisha Ghazi

и другие.

Plants, Год журнала: 2023, Номер 12(7), С. 1541 - 1541

Опубликована: Апрель 3, 2023

The World Health Organization (WHO) reported that there are 37 million individuals living with the human immunodeficiency virus (HIV) worldwide, majority in South Africa. This chronic disease is managed by effective use of antiretroviral (ARV) drugs. However, prolonged use, ARV drug-induced toxicity remains a clinically complex problem. study investigated drugs on mitochondria and NRF2 antioxidant pathway its possible amelioration using Moringa oleifera Lam (MO) leaf extracts. medicinal plant has range functional bioactive compounds. Liver (HepG2) cells were treated individual drugs: Tenofovir disoproxil fumarate (TDF), Emtricitabine (FTC), Lamivudine (3TC) for 96 h, followed MO extracts 24 h. Intracellular ROS, cytotoxicity, lipid peroxidation, total reduced glutathione (GSH), ATP, mitochondrial polarisation determined. Finally, protein (pNRF2, NRF2, SOD2, CAT, Sirt3) mRNA (NRF2, NQO1 Sirt3, PGC1α) expression measured Western blot qPCR, respectively. TDF, FTC, 3TC significantly increased intracellular ROS extracellular levels both MDA LDH. ARVs also GSH ATP altered polarization. Further, NQO1, UCP2 PGC1α consequently pNRF2, Sirt3 CAT protein. In contrast, was significant reduction LDH post-MO treatment. while increasing GSH, membrane addition to ARV-treated upregulated UCP2, PGC1α, proteins. Thus, ameliorates ARV-induced hepatotoxicity scavenging oxidants inducing pathway. shows great therapeutic potential may be considered supplement ameliorate drug toxicity.

Язык: Английский

Процитировано

5
Potential health benefits of combined extracts from germinated brown jasmine rice ( Oryza sativa L.), Moringa oleifera leaves, and Cordyceps militaris DOI Creative Commons
Pongrawee Nimnoi, Neelawan Pongsilp

CyTA - Journal of Food, Год журнала: 2024, Номер 22(1), С. 1 - 11

Опубликована: Янв. 4, 2024

Extracts from powders of geminated brown rice (Oryza sativa L.), Moringa oleifera, and Cordyceps militaris were combined in various ratios their health-beneficial properties investigated. All extracts exerted the synergistic effects on antioxidant activity as well inhibitions against α-amylase α-glucosidase. Extract formulas T4 (70% germinated jasmine rice, 20% M. oleifera dry leaves, 10% C. militaris) T2 (80% elicited significantly highest inhibition α-glucosidase, respectively. Both exhibited α-amylase. As compared to each other, extract possessed higher glucose consumption-promoting antiinflammatory activities, not toxic normal RAW-264.7 SW-480 human colon cancer cells. Bioactive compounds with health-supporting identified using UHPLC-QTOF-MS/MS. These can be promising therapeutic food.

Язык: Английский

Процитировано

1
Moringa oleifera leaves ethanolic extract counteracts cortical neurodegeneration induced by aluminum chloride in rats DOI
Rabab Fawzy Hindawy, Samia Manawy, Ola Elsayed Nafea

и другие.

Toxicology Research, Год журнала: 2024, Номер 13(2)

Опубликована: Март 1, 2024

Abstract Background Aluminum, a well-recognized neurotoxin, is implicated in various neurodegenerative disorders. Moringa oleifera (M. oleifera), known as miracle tree, utilized functional food and nutritional supplement. This study investigates the potential preventive effects of M. extract on aluminum chloride (AlCl3)-induced cortical neurodegeneration rats. Materials methods Therefore, 24 adult male Wistar rats were randomly divided into four distinct groups: negative control, (MOE), AlCl3, AlCl3 + MOE. Treatments administered orally for 28 consecutive days. Cognitive performance, brain oxidative/nitrosative stress, neuroinflammation, apoptotic-cell death, associated histopathological alterations assessed. Results Our results showed that MOE improved spatial learning memory, enhanced antioxidant superoxide dismutase enzyme activity, antagonized nitrosative reduced inflammatory cytokines (tumor necrosis factor-alpha interleukin-6), decreased caspase-3, increased Bcl-2, facilitated repair hippocampal structures. Conclusions We concluded exhibits protective against neurodegeneration, making it promising supplement to counteract aluminum-induced neurotoxic effects.

Язык: Английский

Процитировано

1
Nutraceuticals Unveiled a Multifaceted Neuroprotective Mechanisms for Parkinson’s Disease: Elixir for the Brain DOI

Divya Soni,

Sumit Jamwal, Rakesh Chawla

и другие.

Food Reviews International, Год журнала: 2024, Номер unknown, С. 1 - 24

Опубликована: Апрель 5, 2024

Язык: Английский

Процитировано

1
In silico and pharmacokinetic studies of glucomoringin from Moringa oleifera root for Alzheimer's disease like pathology DOI Creative Commons

Chintalapati Manogna,

Thirumal Margesan

Future Science OA, Год журнала: 2024, Номер 10(1)

Опубликована: Апрель 17, 2024

Aim: The aim of this research is to investigate the potential glucomoringin, derived from Moringa oleifera, as a therapeutic agent for Alzheimer's disease through in silico analysis. Materials & methods: This study employs or computational methodologies, including pkCSM, Swiss ADME, OSIRIS® property explorer, PASS online web resource and MOLINSPIRATION® software, predict pharmacokinetic characteristics biological activity glucomoringin. Results conclusion: Molecular docking indicates strong binding I-1β profile shows cytochrome P450 enzyme inhibition, prompting further dosing strategies. Toxicological predictions affirm safety, while bioactivity assessments demonstrate versatility modulating essential pathways. glucomoringin's treatment, emphasizing need additional empirical research.

Язык: Английский

Процитировано

1
Moringa - The Miracle Tree: An Overview of its Nutritional and Medicinal Properties DOI Open Access

Asma Saghir Khan,

Quratulain Zulfiqar Ali

Asian Journal of Biochemistry Genetics and Molecular Biology, Год журнала: 2023, Номер 15(3), С. 32 - 44

Опубликована: Окт. 17, 2023

Moringa, scientifically known as (Moringa oleifera Lam.), is a multipurpose tree that has gained considerable attention due to its exceptional nutritional and medicinal properties. Native the Indian subcontinent, Moringa now cultivated in various tropical subtropical regions worldwide. This article provides an overview of composition potential health benefits highlighting role valuable resource for combating malnutrition addressing conditions. The information presented here based on review relevant research articles available Google Scholar.

Язык: Английский

Процитировано

2
Synergistic Effects of Multifunctional Phytochemicals Modulating the Cellular Signal Pathways – as Neuroprotective Therapeutic Approach for Neurodegenerative Disorders DOI

Rajalakshmi Manikkam,

Sabapathy Indu,

Vijayalakshmi Periyasamy

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Natural agents that are neuroprotective against mitochondria: a bibliometric-based research mapping 1998–2024, from cells to mitochondria DOI Creative Commons
ARMAN YURISALDI SALEH,

Dwi Arwandi Yogi Saputra

F1000Research, Год журнала: 2024, Номер 13, С. 754 - 754

Опубликована: Июль 5, 2024

Introduction Mitochondria are cell organelles that function as the cell’s main power plant, producing ATP, energy molecule in cells. play an important role context of neuroprotection, and mitochondrial has been implicated various neurodegenerative diseases, including Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis (ALS). Recent research field neuroprotection focused on development therapies target mitochondria. Natural ingredients have long used traditional medicine show potential neuroprotective agents. Methods In this work, a literature review methodology is employed to gather data from Scopus database using keywords natural agents, herb*, neuroprotective, The were analyzed Biblioshiny VOSviewer software produce visualizations bibliometric maps. We conducted quantitative qualitative analyses. Results trend found documents by year, most global cited document, relevant sources, A factorial map illustrating leading contributors papers, author, country or territory, subject area, network visualization, overlay visualization scopus vosviewer, density thematic map, evolution, cluster analysis, word cloud. Conclusions Agent Neurotropik substance influences brain’s nervous system peripheral system, enhancing cognition, mood, brain function. Derived herbs, spices, herbal products, it advantages over other agents production, biogenesis, neuroprotection.

Язык: Английский

Процитировано

0