Talking during walking: the diagnostic potential of turn dynamics in Alzheimer’s disease, mild cognitive impairment and cognitive aging DOI Creative Commons
Hamed Mohammadi, Adel Maghsoudpour, Maryam Noroozıan

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Фев. 19, 2025

While gait analysis is well-documented, turn performance-which a more complex task and involves multiple brain regions-has been less explored. This study aims to assess the diagnostic potential of dynamics as novel tool for detecting cognitive decline. We recruited 75 participants, including 26 neurotypical (NT) older adults, 25 with amnestic mild impairment (aMCI), 24 Alzheimer's disease (AD). Participants completed dual-task walk (DTWT) test using dual Kinect setup while counting backwards by ones. Key measures analyzed included spatial-temporal parameters dynamics. Statistical analyses variance linear regression were performed identify key features well their correlation performance. Gait speed stride time significantly differentiated among groups in DTWT conditions. More notably, dynamics, particularly segmental peak speeds step length, displayed stronger discriminatory power significant p-values compared features. Linear indicated that had correlations executive function working memory, suggesting pronounced relationship between performance than variables. In contrast straight metrics, this shows are sensitive detect impairment. Consequently, incorporating turning movements into techniques could enhance protocols clinical settings, offering valuable monitoring progression conditions associated aging.

Язык: Английский

Talking during walking: the diagnostic potential of turn dynamics in Alzheimer’s disease, mild cognitive impairment and cognitive aging DOI Creative Commons
Hamed Mohammadi, Adel Maghsoudpour, Maryam Noroozıan

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2025, Номер 17

Опубликована: Фев. 19, 2025

While gait analysis is well-documented, turn performance-which a more complex task and involves multiple brain regions-has been less explored. This study aims to assess the diagnostic potential of dynamics as novel tool for detecting cognitive decline. We recruited 75 participants, including 26 neurotypical (NT) older adults, 25 with amnestic mild impairment (aMCI), 24 Alzheimer's disease (AD). Participants completed dual-task walk (DTWT) test using dual Kinect setup while counting backwards by ones. Key measures analyzed included spatial-temporal parameters dynamics. Statistical analyses variance linear regression were performed identify key features well their correlation performance. Gait speed stride time significantly differentiated among groups in DTWT conditions. More notably, dynamics, particularly segmental peak speeds step length, displayed stronger discriminatory power significant p-values compared features. Linear indicated that had correlations executive function working memory, suggesting pronounced relationship between performance than variables. In contrast straight metrics, this shows are sensitive detect impairment. Consequently, incorporating turning movements into techniques could enhance protocols clinical settings, offering valuable monitoring progression conditions associated aging.

Язык: Английский

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