Horticultural Plant Journal, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Journal of Integrative Plant Biology, Год журнала: 2024, Номер 66(12), С. 2586 - 2599
Опубликована: Окт. 4, 2024
ABSTRACT Modifications to RNA have recently been recognized as a pivotal regulator of gene expression in living organisms. More than 170 chemical modifications identified RNAs, with N 6 ‐methyladenosine (m A) being the most abundant modification eukaryotic mRNAs. The addition and removal m A marks are catalyzed by methyltransferases (referred “writers”) demethylases “erasers”), respectively. In addition, mRNAs interpreted A‐binding proteins “readers”), which regulate fate mRNAs, including stability, splicing, transport, translation. Therefore, exploring mechanism underlying reader‐mediated modulation metabolism is essential for much deeper understanding epigenetic role plants. Recent discoveries improved our functions readers plant growth development, stress response, disease resistance. This review highlights latest developments reader research, emphasizing diverse RNA‐binding domains crucial function biological cellular roles response developmental environmental signals. Moreover, we propose discuss potential future research directions challenges identifying novel elucidating mechanistic
Язык: Английский
Процитировано
6
Biology, Год журнала: 2025, Номер 14(1), С. 61 - 61
Опубликована: Янв. 13, 2025
miRNAs are small non-coding RNA molecules that play critical roles in the regulation of gene expression and have been closely associated with various diseases, including cancer. These significantly influence cell cycle tumor cells control programmed death (apoptosis). Currently, research on has become a major focus developing cancer therapies. Osteosarcoma, malignant neoplasm predominantly occurring during adolescence later life, is characterized by high propensity for metastasis. This review explores role initiation progression cancer, highlighting their potential as predictive biomarkers disease. It discusses mechanisms which natural products modulate miRNA activity to apoptosis, ferroptosis, autophagy osteosarcoma cells, aiming identify new strategies treatment. Recent studies how regulate reduce resistance chemotherapy also reviewed. Furthermore, elaborates m6A modifications expression, thereby exerting antitumor effects. In this process, interactions between identified, both jointly influencing tumorigenesis progression, offering perspective approaches could help uncover novel regulatory pathways provide theoretical foundation drugs identifying therapeutic targets.
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2025, Номер 6(3)
Опубликована: Март 1, 2025
ABSTRACT Epigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and most prevalent modification N6‐methyladenosine (m 6 A). Recently, emerged as a potential target for treatment. posttranscriptional gene expression that involved both physiological pathological processes. Evidence suggests m A significantly affects metabolism, its abnormal changes have observed variety diseases. Metabolic diseases are series caused by metabolic processes body, common include diabetes mellitus, obesity, nonalcoholic fatty liver disease, etc.; although pathogenesis these differs from each other to current understanding, recent studies suggested pivotal role modulating diseases, A‐based drug on agenda. This paper reviewed understanding hoping provide systematic information those area.
Язык: Английский
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142597 - 142597
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Horticultural Plant Journal, Год журнала: 2025, Номер unknown
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0