Journal of Neurochemistry,
Год журнала:
2022,
Номер
164(3), С. 266 - 269
Опубликована: Ноя. 16, 2022
Molecular
imaging
techniques
have
become
important
tools
to
characterize
and
measure
biological
processes
at
the
cellular
molecular
levels.
Nowadays,
are
widely
used
in
preclinical
clinical
studies
assess
dynamics
under
physiological
conditions
during
pathological
processes.
This
special
issue
on
Brain
Imaging
(https://onlinelibrary.wiley.com/doi/toc/10.1111/[ISSN]1471-4159.brain-imaging)
will
highlight
some
of
recent
advances
developing
new
applying
understand
biomarker
health
diseases.
Displays,
Год журнала:
2023,
Номер
80, С. 102583 - 102583
Опубликована: Ноя. 15, 2023
The
integration
of
deep
learning
techniques
in
pediatric
neuroimaging
has
shown
significant
promise
advancing
various
aspects
the
field.
This
paper
provides
a
comprehensive
exploration
applications
neuroimaging,
focusing
on
image
processing
and
reconstruction,
segmentation
classification,
brain
abnormalities
detection,
development
maturation
analysis.
It
discusses
key
deep-learning
their
relevance
neuroimaging.
also
addresses
challenges
limitations
such
as
lack
standardization,
ethical
privacy
concerns,
limited
heterogeneous
data,
age,
gender,
developmental
variations.
highlights
future
directions
opportunities,
including
multi-modal
considerations,
diagnosing
initiating
treatment
during
early
stages,
impact
maternal
emotional
well-being
development.
insights
provided
this
aim
to
contribute
understanding
how
can
positively
inspire
further
research
innovation
Ultimately,
adopting
improve
patient
outcomes,
advance
diagnostic
accuracy,
enhance
our
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(11), С. 9465 - 9465
Опубликована: Май 30, 2023
The
discovery
of
the
P2X7
receptor
(P2X7R,
originally
named
P2Z)
in
immune
cells,
its
cloning,
and
identification
role
a
multiplicity
immune-mediated
diseases
raised
great
hopes
for
development
novel
more
potent
anti-inflammatory
medicaments.
Unfortunately,
such
were
partially
deluded
by
unsatisfactory
results
most
early
clinical
trials.
This
failure
substantially
reduced
interest
pharmaceutical
biotech
industries
P2X7R-targeted
therapies.
However,
recent
findings
ushered
second
life
P2X7R
diagnostic
medicine.
New
radioligands
proved
to
be
very
reliable
tools
diagnosis
neuroinflammation
preclinical
studies,
detection
measurement
free
(or
subunit)
human
blood
suggested
potential
use
as
circulating
marker
inflammation.
Here
we
provide
brief
review
these
developments.
Biomolecules,
Год журнала:
2025,
Номер
15(1), С. 47 - 47
Опубликована: Янв. 1, 2025
Tryptophan
(Trp)-based
radiotracers
have
excellent
potential
for
imaging
many
different
types
of
brain
pathology
because
their
involvement
with
both
the
serotonergic
and
kynurenine
(KYN)
pathways.
However,
specific
to
metabolism
pathway
are
limited.
In
addition,
historically
Trp-based
radiopharmaceuticals
were
synthesized
short-lived
isotope
carbon-11.
A
newer
generation
agents
using
longer
half-lived
commercially
available
isotopes,
such
as
fluorine-18
iodine-124,
being
developed.
The
newly
developed
amino
acid-based
tracers
been
demonstrated
favorable
radiochemical
characteristics
in
pre-clinical
studies.
barriers
still
exist
clinical
translation
KYN
pathway-specific
radiotracers.
Current Opinion in Neurobiology,
Год журнала:
2024,
Номер
87, С. 102898 - 102898
Опубликована: Авг. 1, 2024
Misuse
and
accidental
overdoses
attributed
to
stimulants
are
escalating
rapidly.
These
include
methamphetamine,
cocaine,
amphetamine,
ecstasy-type
drugs,
prescription
such
as
methylphenidate.
Unlike
opioids
alcohol,
there
no
therapies
approved
by
the
US
Food
Drug
Administration
(FDA)
treat
stimulant-use
disorder.
The
high
rate
of
relapse
among
this
population
highlights
insufficiency
current
treatment
options,
which
limited
abstinence
support
programs
behavioral
modification
therapies.
Here,
we
briefly
outline
recent
regulatory
actions
taken
FDA
help
development
new
stimulant
use
disorder
treatments
highlight
several
therapeutics
in
clinical
pipeline.
ACS Chemical Neuroscience,
Год журнала:
2023,
Номер
14(4), С. 524 - 526
Опубликована: Фев. 2, 2023
The
arsenal
of
drugs
for
psychiatry
has
been
difficult
to
renew
several
decades.
Many
failures
in
therapeutic
trials
can
be
explained
by
poorly
evaluated
pharmacological
properties,
terms
brain
passage,
target
binding,
and
functional
modulation.
Positron
emission
tomography
provide
pharmacokinetic
pharmacodynamic
data
that
will
help
better
select
candidate
molecules
larger-scale
clinical
trials.
Frontiers in Natural Products,
Год журнала:
2023,
Номер
2
Опубликована: Июль 18, 2023
Cannabinoid
subtype
1
receptors
(CB
Rs)
are
an
important
class
of
G
protein-coupled
(GPCRs)
belonging
to
the
endocannabinoid
system.
CB
Rs
play
a
crucial
modulatory
role
in
functioning
other
neurotransmitter
systems
and
involved
wide
range
physiological
functions
dysfunctions;
thus,
they
considered
one
most
targets
for
drug
development,
as
well
diagnostic
purposes.
Despite
this,
only
few
molecules
targeting
this
receptor
available
on
pharmaceutical
market,
thus
emphasizing
need
gain
deeper
understanding
complex
activation
pathways
how
regulate
diseases.
As
part
review,
we
provide
overview
pharmacological
imaging
tools
useful
detecting
Rs.
Herein,
summarize
derivations
cannabinoids
terpenoids
with
fluorescent
compounds,
radiotracers,
or
photochromic
motifs.
Rs’
molecular
probes
may
be
used
vitro
and,
some
cases,
vivo
investigating
exploring
roles
together
starting
point
development
R-targeted
drugs.
Abstract
Electroconvulsive
therapy
(ECT)
effectively
treats
severe
psychiatric
disorders
such
as
depression,
mania,
catatonia,
and
schizophrenia.
Although
its
exact
mechanism
remains
unclear,
ECT
is
thought
to
induce
neurochemical
neuroendocrine
changes.
Positron
emission
tomography
(PET)
single-photon
computed
(SPECT)
have
provided
vital
insights
into
ECT's
neurobiological
effects.
This
scoping
review
investigates
the
role
of
molecular
imaging
in
understanding
these
A
systematic
search
across
PubMed,
EMBASE,
Web
Science,
Cochrane,
Scopus
databases
yielded
857
unique
records,
from
which
45
peer-reviewed
articles
English
with
longitudinal
PET
or
SPECT
measures
patients
were
included.
The
identifies
2
main
research
directions:
impact
on
brain
activity
neurotransmitters.
Initial
assessed
regional
cerebral
blood
flow
glucose
metabolism
during
ictal
(during
ECT),
postictal
(within
24
hours),
short-term
a
week),
long-term
(beyond
week)
follow-up
markers
activity.
findings
showed
an
anterior-posterior
gradient
phase,
subsequent
normalization
hypoperfusion
frontal
parietal
regions,
persistent
Later,
shifted
monoamine
hypothesis
examining
serotonin
dopamine
systems
via
imaging.
Results
receptor
availability
post-ECT
mixed,
showing
both
reductions
no
significant
changes,
indicating
variable
further
highlights
need
explore
new
targets,
tailor
methodologies
for
patient
populations,
foster
multicenter
studies.
has
been
valuable,
advances
now
make
it
preferable,
offering
unparalleled
mechanisms.
