The International Journal of Biochemistry & Cell Biology,
Год журнала:
2024,
Номер
175, С. 106647 - 106647
Опубликована: Авг. 24, 2024
This
mini-review
presents
our
current
understanding
of
serotonin
type
7
receptor
research
focusing
on
the
possible
network
mechanisms
underlying
behavioral
action
antagonists.
The
is
expressed
widely
throughout
nervous
system
and
known
to
be
involved
in
various
cognitive
physiological
mechanisms.
It
became
a
clinically
significant
target
after
discovery
that
its
selective
antagonist
SB
269970
can
exert
rapid-onset
antidepressant
effects
either
alone
or
combination
with
lower
doses
conventional
drugs.
Further
has
shown
administration
effectively
counteract
negative
neurobiological
outcomes
chronic
stress
paradigms.
authors
hope
they
introduce
wider
scientific
audience
this
promising
pharmacological
which,
if
successful,
could
time
lead
more
discoveries
better
biology
as
well
clinical
potential.
HIGHLIGHTS.
ACS Medicinal Chemistry Letters,
Год журнала:
2025,
Номер
16(3), С. 373 - 374
Опубликована: Фев. 13, 2025
Provided
herein
are
novel
tryptamine
compounds
as
5-HT2A
agonists,
pharmaceutical
compositions,
use
of
such
in
treating
mood
disorders
depressive
and
bipolar
processes
for
preparing
compounds.
ACS Medicinal Chemistry Letters,
Год журнала:
2025,
Номер
16(4), С. 508 - 509
Опубликована: Март 13, 2025
Provided
herein
are
novel
compounds
as
5-HT2A
receptor
modulators,
pharmaceutical
compositions,
use
of
such
in
treating
psychiatric
and
neurological
disorders
processes
for
preparing
compounds.
ACS Medicinal Chemistry Letters,
Год журнала:
2024,
Номер
16(1), С. 32 - 33
Опубликована: Дек. 20, 2024
Provided
herein
are
novel
ergoline
compounds
as
5-HT2A
agonists,
pharmaceutical
compositions,
use
of
such
in
treating
mood
disorders
depressive
and
bipolar
disorders,
processes
for
preparing
compounds.
Ear Nose & Throat Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 27, 2024
Objective:
Depressive
symptoms
are
prevalent
and
detrimental
in
elderly
patients
with
obstructive
sleep
apnea
(OSA).
Understanding
the
factors
influencing
these
is
crucial.
This
study
aims
to
use
machine
learning
algorithms
identify
contributing
this
population.
Method:
The
National
Health
Nutrition
Examination
Survey
database
provided
data
for
study.
includes
who
eligible
diagnostic
evaluation
OSA.
Logistic
regression
was
used
screen
their
factors,
random
forest
(RF),
extreme
gradient
boosting
(XGB),
artificial
neural
network
(ANN),
support
vector
(SVM)
were
utilized
4
construct
depressive
classification
models,
best
model
performance
selected
feature
importance
ranking.
Influential
included
demographics
(age,
gender,
education,
etc.),
chronic
disease
status
(diabetes,
hypertension,
laboratory
findings
(white
blood
cells,
C-reactive
protein,
cholesterol,
etc.).
Result:
Ultimately,
we
chose
1538
OSA
study,
out
of
which
528
(34.4%)
suffered
from
symptoms.
initially
identified
17
then
constructed
models
based
on
those
using
RF,
XGB,
ANN,
SVM.
We
best-performing
SVM
[area
under
curve
(AUC)
=
0.746]
AUC
values
0.73,
0.735,
0.742,
0.746
models.
ranked
variables
order
importance:
General
health
status,
disorders,
frequency
urinary
incontinence,
liver
disease,
physical
activity
limitations,
moisture,
eosinophils,
erythrocyte
distribution
width,
hearing
loss.
Conclusion:
Elderly
experience
a
high
incidence
symptoms,
influenced
by
various
objective
subjective
factors.
situation
troubling,
healthcare
institutions
policymakers
must
prioritize
mental
health.
should
implement
targeted
initiatives
improve
high-risk
groups
multiple
dimensions.
The International Journal of Biochemistry & Cell Biology,
Год журнала:
2024,
Номер
175, С. 106647 - 106647
Опубликована: Авг. 24, 2024
This
mini-review
presents
our
current
understanding
of
serotonin
type
7
receptor
research
focusing
on
the
possible
network
mechanisms
underlying
behavioral
action
antagonists.
The
is
expressed
widely
throughout
nervous
system
and
known
to
be
involved
in
various
cognitive
physiological
mechanisms.
It
became
a
clinically
significant
target
after
discovery
that
its
selective
antagonist
SB
269970
can
exert
rapid-onset
antidepressant
effects
either
alone
or
combination
with
lower
doses
conventional
drugs.
Further
has
shown
administration
effectively
counteract
negative
neurobiological
outcomes
chronic
stress
paradigms.
authors
hope
they
introduce
wider
scientific
audience
this
promising
pharmacological
which,
if
successful,
could
time
lead
more
discoveries
better
biology
as
well
clinical
potential.
HIGHLIGHTS.
