Role of voltage-gated chloride channels in epilepsy: current insights and future directions DOI Creative Commons
Ming-ming Ni,

Jieyu Sun,

Zheng‐Qian Li

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 28, 2025

Epilepsy is a prevalent chronic neurological disorder characterised by recurrent seizures caused excessive neuronal discharge. Disruptions in chloride ion homeostasis significantly affect excitability, and play crucial role the pathophysiology of this disorder. This review highlights emerging importance voltage-gated channels epilepsy, which has been largely underappreciated compared to cation channels. Recent studies have suggested that genetic alterations channels, such as CLCN1, CLCN2, CLCN3, CLCN4, CLCN6, contribute excitability seizure susceptibility, with variations these acting more susceptibility factors than direct causes. However, there significant gap research on other particularly ClC-Ka, ClC-Kb, ClC-5, ClC-7, whose roles epilepsy remain underexplored. Future should focus better understand their contribution epilepsy. The incorporation tests for channel variants clinical practice could provide valuable insight into aetiology leading improved diagnostic therapeutic strategies affected individuals.

Язык: Английский

Role of voltage-gated chloride channels in epilepsy: current insights and future directions DOI Creative Commons
Ming-ming Ni,

Jieyu Sun,

Zheng‐Qian Li

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 28, 2025

Epilepsy is a prevalent chronic neurological disorder characterised by recurrent seizures caused excessive neuronal discharge. Disruptions in chloride ion homeostasis significantly affect excitability, and play crucial role the pathophysiology of this disorder. This review highlights emerging importance voltage-gated channels epilepsy, which has been largely underappreciated compared to cation channels. Recent studies have suggested that genetic alterations channels, such as CLCN1, CLCN2, CLCN3, CLCN4, CLCN6, contribute excitability seizure susceptibility, with variations these acting more susceptibility factors than direct causes. However, there significant gap research on other particularly ClC-Ka, ClC-Kb, ClC-5, ClC-7, whose roles epilepsy remain underexplored. Future should focus better understand their contribution epilepsy. The incorporation tests for channel variants clinical practice could provide valuable insight into aetiology leading improved diagnostic therapeutic strategies affected individuals.

Язык: Английский

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