Journal of Neurochemistry, Год журнала: 2025, Номер 169(5)
Опубликована: Май 1, 2025
ABSTRACT Astrocytes have essential functions in the brain as partners of neurons many metabolic and homeostatic processes. The metabolism tripeptide GSH (γ‐L‐glutamyl‐L‐cysteinyl‐glycine) is an important example a interaction between astrocytes neurons. present cells millimolar concentrations has antioxidant substrate for detoxification reactions. A high content protects against oxidative stress toxins therefore beneficial astrocytic self‐defense that helps to maintain will enable eliminate potential before they may reach other cells. In addition, provide with amino acids required synthesis process involves export from by multidrug resistance protein 1, extracellular processing via γ‐glutamyl transpeptidase generate dipeptide cysteinyl‐glycine, cleavage this neuronal ectopeptidase aminopeptidase N. As strongly depends on cytosolic concentration, also facilitate release thereby supply precursors neighboring article, we give overview current knowledge astrocytes, address how can help functions, discuss open questions future perspectives research healthy diseased brain. image
Язык: Английский