(Re)building the nervous system: A review of neuron–glia interactions from development to disease DOI Creative Commons
Matthew D. Demmings, Luana da Silva Chagas, Marianela E. Traetta

и другие.

Journal of Neurochemistry, Год журнала: 2024, Номер 169(1)

Опубликована: Дек. 16, 2024

Abstract Neuron–glia interactions are fundamental to the development and function of nervous system. During development, glia, including astrocytes, microglia, oligodendrocytes, influence neuronal differentiation migration, synapse formation refinement, myelination. In mature brain, glia crucial for maintaining neural homeostasis, modulating synaptic activity, supporting metabolic functions. Neurons, inherently vulnerable various stressors, rely on protection repair. However, in their reactive state, can also promote damage, which contributes neurodegenerative neuropsychiatric diseases. Understanding dual role glia—as both protectors potential aggressors—sheds light complex contributions disease etiology pathology. By appropriately glial it may be possible mitigate neurodegeneration restore function. this review, originated from International Society Neurochemistry (ISN) Advanced School 2019 held Montreal, Canada, we first describe critical importance maintenance a healthy system as well damage neurological disorders. We then discuss strategies modulate activity during protect properly functioning propose that targeting cells presents promising therapeutic avenue rebuilding image

Язык: Английский

Multi-scale Neural Homeostasis Mechanisms: Insights into Neurodegenerative Diseases and Therapeutic Approaches, Including Exercise DOI Creative Commons
Ya Wang, Xuhui Chen, Cuntai Zhang

и другие.

Advanced Exercise and Health Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
(Re)building the nervous system: A review of neuron–glia interactions from development to disease DOI Creative Commons
Matthew D. Demmings, Luana da Silva Chagas, Marianela E. Traetta

и другие.

Journal of Neurochemistry, Год журнала: 2024, Номер 169(1)

Опубликована: Дек. 16, 2024

Abstract Neuron–glia interactions are fundamental to the development and function of nervous system. During development, glia, including astrocytes, microglia, oligodendrocytes, influence neuronal differentiation migration, synapse formation refinement, myelination. In mature brain, glia crucial for maintaining neural homeostasis, modulating synaptic activity, supporting metabolic functions. Neurons, inherently vulnerable various stressors, rely on protection repair. However, in their reactive state, can also promote damage, which contributes neurodegenerative neuropsychiatric diseases. Understanding dual role glia—as both protectors potential aggressors—sheds light complex contributions disease etiology pathology. By appropriately glial it may be possible mitigate neurodegeneration restore function. this review, originated from International Society Neurochemistry (ISN) Advanced School 2019 held Montreal, Canada, we first describe critical importance maintenance a healthy system as well damage neurological disorders. We then discuss strategies modulate activity during protect properly functioning propose that targeting cells presents promising therapeutic avenue rebuilding image

Язык: Английский

Процитировано

2