Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s Disease DOI Creative Commons
Ana Volarevic, Carl Randall Harrell, Aleksandar Arsenijević

и другие.

Cells, Год журнала: 2025, Номер 14(8), С. 600 - 600

Опубликована: Апрель 16, 2025

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the gradual loss of dopamine-producing neurons. Oxidative stress, mitochondrial dysfunction, detrimental immune response, and neuroinflammation are mainly responsible for injury degeneration dopaminergic neurons in brains patients suffering from PD. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as promising therapeutic approach treating PD due to their ability suppress activation inflammatory cells enhance viability function MSC-EVs can easily bypass blood-brain barrier deliver cargo (neuroprotective factors, immunosuppressive proteins, microRNAs) injured brain-infiltrated cells. A large number recently published experimental studies demonstrated that efficiently alleviated PD-related motor behavioral deficits animal models, indicating should be considered potentially new agents treatment Accordingly, this review article, we summarized current knowledge about potential MSCs-EVs PD, paving way future clinical use neuroinflammatory disorders.

Язык: Английский

Therapeutic Potential of Mesenchymal Stem Cell-Derived Extracellular Vesicles in the Treatment of Parkinson’s Disease DOI Creative Commons
Ana Volarevic, Carl Randall Harrell, Aleksandar Arsenijević

и другие.

Cells, Год журнала: 2025, Номер 14(8), С. 600 - 600

Опубликована: Апрель 16, 2025

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the gradual loss of dopamine-producing neurons. Oxidative stress, mitochondrial dysfunction, detrimental immune response, and neuroinflammation are mainly responsible for injury degeneration dopaminergic neurons in brains patients suffering from PD. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have emerged as promising therapeutic approach treating PD due to their ability suppress activation inflammatory cells enhance viability function MSC-EVs can easily bypass blood-brain barrier deliver cargo (neuroprotective factors, immunosuppressive proteins, microRNAs) injured brain-infiltrated cells. A large number recently published experimental studies demonstrated that efficiently alleviated PD-related motor behavioral deficits animal models, indicating should be considered potentially new agents treatment Accordingly, this review article, we summarized current knowledge about potential MSCs-EVs PD, paving way future clinical use neuroinflammatory disorders.

Язык: Английский

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