Ginsenoside Rb1 ameliorates the abnormal hepatic glucose metabolism by activating STAT3 in T2DM mice DOI Creative Commons
Weixuan Wang,

Wenjing Zhan,

Mingjie Liang

и другие.

Journal of Functional Foods, Год журнала: 2023, Номер 104, С. 105534 - 105534

Опубликована: Апрель 8, 2023

Ginsenoside Rb1, a major bioactive component of Panax ginseng C. A. Mey., exerts beneficial effects on type 2 diabetes mellitus (T2DM), but its underlying mechanism is unclear. STAT3 key factor regulating energy metabolism. Herein, we tested whether Rb1 regulates STAT3-controlled hepatic glucose metabolism to ameliorate T2DM. ameliorated abnormal metabolism, insulin resistance, and liver steatosis in T2DM mice. Hepatic phosphorylation was decreased increased after treatment. Moreover, reversed the expressions glycolytic enzymes gluconeogenic activation vitro, vice versa. Further, inhibition changes these induced by insulin-resistant cells. Taken together, STAT3-dependent manner, which provides experimental bases for treating

Язык: Английский

Estrogen as a key regulator of energy homeostasis and metabolic health DOI
Fatemeh Mahboobifard, Mohammad H. Pourgholami, Masoumeh Jorjani

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 156, С. 113808 - 113808

Опубликована: Окт. 15, 2022

Язык: Английский

Процитировано

75

Central nervous system regulation of organismal energy and glucose homeostasis DOI
Martin G. Myers, Alison H. Affinati, Nicole E. Richardson

и другие.

Nature Metabolism, Год журнала: 2021, Номер 3(6), С. 737 - 750

Опубликована: Июнь 21, 2021

Язык: Английский

Процитировано

105

Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets DOI Creative Commons
Yikuan Du, Yong Huo, Yujia Yang

и другие.

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 11, 2025

The prevalence of obesity and osteoporosis (OP) represents a significant public health concern on global scale. A substantial body evidence indicates that there is complex relationship between OP, with correlation the occurrence OP obesity. In recent years, sirtuins have emerged as prominent area interest in fields aging endocrine metabolism. Among various research avenues exploring potential sirtuins, effects these proteins garnered attention from numerous researchers. Sirtuins regulate energy balance lipid balance, which turn inhibit process adipogenesis. Additionally, osteogenic osteoblastic activity, protects against development OP. However, no study has yet provided comprehensive discussion three: obesity, This paper will therefore describe focusing possibility treating caused by targeting sirtuins. be based common influences (such mesenchymal stem cells, gut microbiota, insulin). Finally, SIRT1, an important member polyphenolic natural products for treatment presented. contribute to better understanding interactions bone, facilitate new therapeutic strategies future.

Язык: Английский

Процитировано

1

Multiple Sclerosis: Melatonin, Orexin, and Ceramide Interact with Platelet Activation Coagulation Factors and Gut-Microbiome-Derived Butyrate in the Circadian Dysregulation of Mitochondria in Glia and Immune Cells DOI Open Access
George Anderson, Moses Rodriguez, Russel J. Reíter

и другие.

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(21), С. 5500 - 5500

Опубликована: Ноя. 5, 2019

Recent data highlight the important roles of gut microbiome, permeability, and alterations in mitochondria functioning pathophysiology multiple sclerosis (MS). This article reviews such data, indicating two aspects modulation mitochondria: (1) Gut permeability increases toll-like receptor (TLR) activators, viz circulating lipopolysaccharide (LPS), exosomal high-mobility group box (HMGB)1. LPS HMGB1 increase inducible nitric oxide synthase superoxide, leading to peroxynitrite-driven acidic sphingomyelinase ceramide. Ceramide is a major driver MS via its impacts on glia functioning; (2) dysbiosis lowers production short-chain fatty acid, butyrate. Butyrate significant positive regulator mitochondrial function, as well suppressing levels effects acts suppress circadian optimizers functioning, daytime orexin night-time melatonin. Orexin, melatonin, butyrate oxidative phosphorylation partly disinhibition pyruvate dehydrogenase complex, an acetyl-coenzyme A (CoA). Acetyl-CoA necessary co-substrate for activation melatonergic pathway, allowing melatonin optimize function. Data would indicate that gut-driven ceramide particularly immune cells, underpin pathophysiology. Aryl hydrocarbon (AhR) stress-induced kynurenine air pollutants, may interact with pathway AhR-induced cytochrome P450 (CYP)1b1, which backward converts N-acetylserotonin (NAS). The loss mitochnodria coupled increased NAS has implications altered function many cell types are relevant secondary progressive MS, role changes progression symptomatology. provides framework integration diverse bodies pathophysiology, number readily applicable treatment interventions, including utilization sodium

Язык: Английский

Процитировано

74

The functional architecture of human motivation: Personality systems interactions theory DOI
Julius Kühl, Markus Quirin, Sander L. Koole

и другие.

Advances in motivation science, Год журнала: 2020, Номер unknown, С. 1 - 62

Опубликована: Июль 22, 2020

Язык: Английский

Процитировано

52

The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis DOI Creative Commons
Longlong Tu, Makoto Fukuda, Qingchun Tong

и другие.

Cell & Bioscience, Год журнала: 2022, Номер 12(1)

Опубликована: Май 26, 2022

Abstract The brain, particularly the ventromedial hypothalamic nucleus (VMH), has been long known for its involvement in glucose sensing and whole-body homeostasis. However, it is still not fully understood how brain detects responds to changes circulating levels, as well brain-body coordinated control of In this review, we address growing evidence implicating homeostasis, especially contexts hypoglycemia diabetes. addition neurons, emphasize potential roles played by non-neuronal cells, extracellular matrix hypothalamus Further, review ionic mechanisms which glucose-sensing neurons sense fluctuations ambient levels. We also introduce significant implications heterogeneous VMH upon sex difference addressed. Meanwhile, research gaps have identified, necessities further mechanistic studies future.

Язык: Английский

Процитировано

30

Hypothalamic Estrogen Signaling and Adipose Tissue Metabolism in Energy Homeostasis DOI Creative Commons
Valeria C. Torres Irizarry, Yuwei Jiang, Yanlin He

и другие.

Frontiers in Endocrinology, Год журнала: 2022, Номер 13

Опубликована: Июнь 9, 2022

Obesity has become a global epidemic, and it is major risk factor for other metabolic disorders such as type 2 diabetes cardiometabolic disease. Accumulating evidence indicates that there sex-specific protection disease susceptibility. For instance, in both clinical experimental studies, males are more likely to develop obesity, insulin resistance, diabetes. In line with this, tend have visceral white adipose tissue (WAT) less brown (BAT) thermogenic activity, leading an increased incidence of disorders. This female-specific fat distribution partially mediated by sex hormone estrogens. Specifically, hypothalamic estrogen signaling plays vital role regulating WAT distribution, beiging, BAT thermogenesis. These regulatory effects on metabolism primarily the activation receptor alpha (ERα) neurons, which interacts hormones adipokines leptin, ghrelin, insulin. review discusses contribution dysfunction obesity preventing diseases particular focus VMH, central regulator energy expenditure glucose homeostasis.

Язык: Английский

Процитировано

29

Brain insulin signaling as a potential mediator of early life adversity effects on physical and mental health DOI Creative Commons
Bonnie Alberry, Patrícia Pelufo Silveira

Neuroscience & Biobehavioral Reviews, Год журнала: 2023, Номер 153, С. 105350 - 105350

Опубликована: Авг. 6, 2023

In numerous brain structures, insulin signaling modulates the homeostatic processes, sensitivity to reward pathways, executive function, memory, and cognition. Through human studies animal models, mounting evidence implicates central in metabolic, physiological, psychological consequences of early life adversity. this review, we describe adversity where is a key factor how may moderate effects on psychiatric cardio-metabolic health outcomes. Further understanding impact specific regions mental physical outcomes will assist prevention, diagnosis, potential intervention following

Язык: Английский

Процитировано

18

Neuronal glucose sensing mechanisms and circuits in the control of insulin and glucagon secretion DOI
Bernard Thorens

Physiological Reviews, Год журнала: 2024, Номер 104(4), С. 1461 - 1486

Опубликована: Апрель 25, 2024

Glucose homeostasis is mainly under the control of pancreatic islet hormones insulin and glucagon, which, respectively, stimulate glucose uptake utilization by liver, fat, muscle production liver. The balance between secretions these blood concentrations. Indeed, β-cells α-cells can sense variations in glycemia respond an appropriate secretory response. However, activity cells also multiple additional metabolic, hormonal, neuronal signals that combine to ensure perfect over a lifetime. central nervous system (CNS), which has almost absolute requirement for as source metabolic energy thus vital interest ensuring glycemic levels never fall below ∼5 mM, equipped with populations neurons responsive changes These cell secretion ways: through both branches autonomic system, hypothalamic-pituitary-adrenal axis, secreting vasopressin (AVP) at level posterior pituitary. Here, we present innervation islets; mechanisms neuron activation rise or concentration; how current viral tracing, chemogenetic, optogenetic techniques allow integration specific sensing defined circuits endocrine pancreas function; and, finally, genetic screens mice untangle diversity hypothalamic controlling response hypoglycemia.

Язык: Английский

Процитировано

7

Sustained remission of type 2 diabetes in rodents by centrally administered fibroblast growth factor 4 DOI Creative Commons
Hongbin Sun,

Wei Lin,

Yu Tang

и другие.

Cell Metabolism, Год журнала: 2023, Номер 35(6), С. 1022 - 1037.e6

Опубликована: Май 10, 2023

Язык: Английский

Процитировано

14