Oxytocin and vasopressin signaling in health and disease
Trends in Biochemical Sciences,
Год журнала:
2024,
Номер
49(4), С. 361 - 377
Опубликована: Фев. 27, 2024
Neurohypophysial
peptides
are
ancient
and
evolutionarily
highly
conserved
neuropeptides
that
regulate
many
crucial
physiological
functions
in
vertebrates
invertebrates.
The
human
neurohypophysial
oxytocin/vasopressin
(OT/VP)
signaling
system
with
its
four
receptors
has
become
an
attractive
drug
target
for
a
variety
of
diseases,
including
cancer,
pain,
cardiovascular
indications,
neurological
disorders.
Despite
promise,
development
faces
hurdles,
complexity,
selectivity
off-target
concerns,
translational
interspecies
differences,
inefficient
delivery.
In
this
review
we
dive
into
the
complexity
OT/VP
health
disease,
provide
overview
relevant
pharmacological
probes,
discuss
latest
trends
therapeutic
lead
discovery
development.
Язык: Английский
Gut microbiota and eating behaviour in circadian syndrome
Trends in Endocrinology and Metabolism,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 1, 2024
Язык: Английский
Enteric Dysbiosis in Children With Autism Spectrum Disorder and Associated Response to Stress
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 31, 2024
Background
Microbiome
studies
in
humans,
though
limited,
have
facilitated
the
evaluation
of
potential
connection
between
microbiome
and
brain
function.
Children
with
autism
spectrum
disorder
(ASD)
several
behavioral
challenges
avoidant/restrictive
food
intake
disorder,
which
may
contribute
to
gut
dysbiosis.
Aim
The
aim
this
study
is
examine
extent
children
ASD
differs
comparison
neurotypical
development
(CWND)
assess
whether
a
probiotic
intervention
has
influence
mediating
positive
behavior
change
stress
regulation.
Methods
This
pilot
collected
data
from
three
four
CWND
before
after
four-week
intervention.
Data
collection
included
diversity
screening
stool
samples
as
well
following
biophysiological
measures:
salivary
alpha-amylase
(sAA)
levels,
response
simulated
stressor
calming
stimulus
(behavior),
including
pulse
rate,
galvanic
skin
response,
pupil
diameter
(PD).
In
addition,
telomere
length
was
assessed.
All
measures,
except
for
length,
were
repeated
on
groups
pre-/post-comparison.
analysis
consisted
multivariate
analyses,
ANOVA.
Results
While
greater
heterogeneity
group
evident
all
participants
who
received
differed
pretreatment
results
within
across
investigated.
Further,
parameter
sAA
displayed
significant
increase
baseline
exposure
both
groups,
whereas
PD
increased
baseline,
F(11,
26615)
=
123.43,
p
0.00.
Conclusion
Though
diminished
compared
CWND,
gap
narrowed
brief
suggest
that
interventions
rescue
abundance,
potentially
supporting
regulation
pediatric
populations.
Язык: Английский
Immunoglobulin G is a natural oxytocin carrier which modulates oxytocin receptor signaling: relevance to aggressive behavior in humans
Discover Mental Health,
Год журнала:
2023,
Номер
3(1)
Опубликована: Окт. 19, 2023
Oxytocin
is
a
neuropeptide
produced
mainly
in
the
hypothalamus
and
secreted
CNS
blood.
In
brain,
it
plays
major
role
promoting
social
interactions.
Here
we
show
that
human
plasma
about
60%
of
oxytocin
naturally
bound
to
IgG
which
modulates
receptor
signaling.
Further,
found
violent
aggressive
inmates
were
characterized
by
lower
affinity
for
oxytocin,
causing
decreased
carrier
capacity
reduced
activation
as
compared
men
from
general
population.
Moreover,
peripheral
administration
together
with
oxytocin-reactive
resident
mice
resident-intruder
test,
c-fos
several
brain
regions
involved
regulation
aggressive/defensive
behavior
correlating
attack
number
duration.
We
conclude
natural
protein
modulating
signaling
can
be
relevant
biological
mechanisms
behavior.
Язык: Английский
Recent Advances in the Mechanisms of Emotional Actions Regulated by Food-Derived and Endogenous Peptides
Food Reviews International,
Год журнала:
2024,
Номер
unknown, С. 1 - 23
Опубликована: Дек. 23, 2024
Emotion
dysregulation
can
cause
abnormalities
in
human
central
nervous
system,
which
turn
affect
the
endocrine,
immune,
and
enteric
systems,
thus
reducing
immune
capacity
increasing
possibility
of
tumor
induction.
Several
endogenous
peptides
newly
discovered
food-derived
exogenous
have
been
found
could
regulate
emotions.
This
review
discussed
how
from
various
sources
emotions
gut
microbiota
through
mechanisms
like
microbiota-gut-brain
axis,
pathways,
metabolic
pathways.
It
also
analyzed
connection
between
their
effects
on
tumorigenesis
cancer
therapy.
And
potential
use
emotion-regulating
treating
tumors,
concluded
these
serve
as
signaling
molecules
axis
for
emotion
regulation.
Future
research
will
prioritize
studying
to
treat
depression
prevent/treat
tumors.
Язык: Английский
The Embodied Microbiome
American Journal of Biomedical Science & Research,
Год журнала:
2023,
Номер
20(3), С. 324 - 339
Опубликована: Окт. 20, 2023
Microbes
are
the
most
prevalent
and
widely
distributed
life
form
on
planet
Earth.
They
also
cognitive
organisms
with
memory
superior
problem-solving
skills
that
use
quantum
phase
transitions
during
their
remarkably
effective
gathering
dissemination
of
information.
This
narrative
review
explores
biological
ramifications
human
holobionts
physically
embodying
microbiome
connecting
to
Internet
(IOM)
beyond
our
body.
Within
review,
we
consider:
Язык: Английский
The Embodied Microbiome
Rodney R. Dietert,
Janice M. Dietert
Опубликована: Сен. 1, 2023
Microbes
are
the
most
prevalent
and
widely-distributed
life
form
on
planet
Earth.
They
also
cognitive
organisms
with
memory
superior
problem-solving
skills
that
use
quantum
phase
transitions
during
their
remarkably-effective
gathering
dissemination
of
information.
This
narrative
review
explores
biological
ramifications
human
holobionts
physically
embodying
microbiome
connecting
to
Internet
(IOM)
beyond
our
body.
Within
review,
we
consider:
1)
ways
in
which
microbial
co-partners
exerted
control
over
ancestors
continue
influence
current
generation,
2)
how
they
mold
virtually
every
key
aspect
even
remain
body
death
3)
inward-looking
contemplative
tools
such
as
meditation
embodied
cognition
provide
an
ideal
opportunity
connect
information
super
highway
tap
full
range
holobiont
capacities.
Язык: Английский
Antiparasitic products and the gut microbiome
Veterinary Record,
Год журнала:
2024,
Номер
195(3), С. 115 - 115
Опубликована: Авг. 2, 2024
Язык: Английский
Oxytocin/Oxytocin Receptor Signalling in the Gastrointestinal System: Mechanisms and Therapeutic Potential
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 10935 - 10935
Опубликована: Окт. 11, 2024
The
neuropeptide
hormone
oxytocin
(OT)
is
involved
in
various
physiological
and
pathological
processes
via
the
receptor
(OTR).
While
OT
most
widely
known
as
a
reproductive
system
nervous
neurotransmitter,
OT/OTR
has
gradually
gained
much
attention
for
its
role
gastrointestinal
(GI)
system,
such
GI
motility,
secretion,
bowel
inflammatory
reactions.
Its
importance
cancers
also
been
reported
past
few
decades.
promising
clinical
observations
have
revealed
OT's
anti-nociceptive
effect,
protective
effect
over
gut
injury,
potential
of
using
microbiota
to
naturally
increase
endogenous
levels,
which
shed
light
on
management
disorders
with
lower
side
effects.
However,
no
current
comprehensive
review
available
actions
tract.
This
aims
present
lesser-known
tract,
recent
findings
are
discussed
regarding
distribution
functional
OTR
signalling
regulating
(patho)physiological
functions
Special
emphasis
placed
therapeutic
disorders,
pain,
disease
(IBD),
irritable
syndrome
(IBS).
characterisation
OTR's
crystal
structure
advanced
research
designing
identifying
new
OTR-specific
molecules.
Future
in-depth
basic
needed
further
elucidate
involvement
detailed
mechanism
development
ligands.
Язык: Английский
Bidirectional relationship between gastrointestinal cancer and depression: The key is in the microbiota-gut-brain axis
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
30(48), С. 5104 - 5110
Опубликована: Ноя. 29, 2024
In
this
Editorial,
we
review
the
recent
publication
in
World
Journal
of
Gastroenterology
,
which
explores
complex
relationship
between
depression
and
gastric
cancer
offers
perspectives.
Key
topics
discussed
include
microbiota-gut-brain
axis,
dysbiosis,
influence
microbial
metabolites
homeostasis.
Additionally,
address
toxic
stress
caused
by
hypothalamic-pituitary-adrenal
axis
dysregulation,
psychological
assessments,
future
research
directions.
Our
Editorial
aims
to
expand
understanding
bidirectional
gastrointestinal
cancer.
Язык: Английский