Whole‐brain mapping of monosynaptic afferent inputs to the CRH neurons in the medial prefrontal cortex of mice DOI
Xiao‐Lan Li, Fei Li, Xinyi Zhu

и другие.

Journal of Anatomy, Год журнала: 2023, Номер 244(3), С. 527 - 536

Опубликована: Ноя. 27, 2023

Abstract Corticotropin‐releasing hormone (CRH) neurons are densely distributed in the medial prefrontal cortex (mPFC), which plays a crucial role integrating and processing emotional cognitive inputs from other brain regions. Therefore, it is important to know neural afferent patterns of mPFC CRH neurons, still unclear. Here, we utilized rabies virus‐based monosynaptic retrograde tracing system map presynaptic afferents throughout entire brain. The results show that receive three main groups regions: (1) cortex, primarily orbital somatomotor areas, anterior cingulate cortex; (2) thalamus, anteromedial nucleus, mediodorsal thalamic central nucleus; (3) regions, basolateral amygdala, hippocampus, dorsal raphe nucleus. Taken together, our valuable for further investigations into roles normal neurological disease states. These can shed light on various aspects such as processing, modulation, motivation, sociability, pain.

Язык: Английский

An Interaction between Brain-Derived Neurotrophic Factor and Stress-Related Glucocorticoids in the Pathophysiology of Alzheimer’s Disease DOI Open Access

Tadahiro Numakawa,

Ryutaro Kajihara

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1596 - 1596

Опубликована: Янв. 27, 2024

Both the brain-derived neurotrophic factor (BDNF) and glucocorticoids (GCs) play multiple roles in various aspects of neurons, including cell survival synaptic function. BDNF its receptor TrkB are extensively expressed neurons central nervous system (CNS), contribution BDNF/TrkB to neuronal function is evident; thus, downregulation has been considered be involved pathogenesis Alzheimer’s disease (AD). GCs, stress-related molecules, glucocorticoid receptors (GRs) also associated with AD addition mental disorders such as depression. Importantly, a growing body evidence suggests close relationship between BDNF/TrkB-mediated signaling GCs/GR CNS. Here, we introduce current studies on interaction stress CNS discuss their involvement pathophysiology AD.

Язык: Английский

Процитировано

11
Understanding the mechanisms of disease modifying effects of aerobic exercise in people with Alzheimer’s disease DOI
Auwal Abdullahi, Thomson W. L. Wong, Shamay S. M. Ng

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 94, С. 102202 - 102202

Опубликована: Янв. 23, 2024

Язык: Английский

Процитировано

9
Validity of mental and physical stress models DOI Creative Commons

Erin Hendry,

Brady McCallister,

Dan J. Elman

и другие.

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 158, С. 105566 - 105566

Опубликована: Фев. 2, 2024

Язык: Английский

Процитировано

6
Nucleus Accumbens Corticotropin-Releasing Hormone Neurons Projecting to the Bed Nucleus of the Stria Terminalis Promote Wakefulness and Positive Affective State DOI Creative Commons
Gaojie Pan, Bing Zhao, Mutian Zhang

и другие.

Neuroscience Bulletin, Год журнала: 2024, Номер 40(11), С. 1602 - 1620

Опубликована: Июль 9, 2024

Abstract The nucleus accumbens (NAc) plays an important role in various emotional and motivational behaviors that rely on heightened wakefulness. However, the neural mechanisms underlying relationship between arousal emotion regulation NAc remain unclear. Here, we investigated roles of a specific subset inhibitory corticotropin-releasing hormone neurons (NAc CRH ) regulating mice. We found increased activity during wakefulness rewarding stimulation. Activation converts NREM or REM sleep to wakefulness, while inhibition these attenuates Remarkably, activation induces place preference response (PPR) decreased basal anxiety level, whereas their inactivation aversion anxious state. are identified as major projection bed stria terminalis (BNST). Furthermore, -BNST pathway similarly induced positive behaviors. Taken together, forebrain promotes associated with affective states.

Язык: Английский

Процитировано

5
Brain monoamine changes modulate the corticotropin-releasing hormone receptor 1-mediated behavioural response to acute thermal stress in zebrafish larvae DOI Creative Commons
Jithine Jayakumar Rajeswari,

Geneece Nicole Yvonne Gilbert,

Enezi Khalid

и другие.

Molecular and Cellular Endocrinology, Год журнала: 2025, Номер unknown, С. 112494 - 112494

Опубликована: Фев. 1, 2025

While central monoamines play a role in regulating stress-related locomotory activity, the modulation of by corticosteroid stress axis shaping acute behavioural responses are unclear. We investigated whether corticotropin-releasing hormone receptor 1 (Crhr1) behavioral response involves monoamine regulation subjecting Crhr1 knockout (crhr1-/-) zebrafish (Danio rerio) to an thermal stressor (TS: + 5 °C above ambient for 60 min). The TS-induced cortisol and hyper activity WT larvae was abolished fish lacking Crhr1. However, both genotypes induced heat shock protein TS. crhr1-/- showed region-specific difference distribution serotonin (5-HT)- tyrosine hydroxylase-positive cells brain. This corresponded with increases whole-body transcript abundance dopamine beta-hydroxylase, tryptophan hydroxylase 2, solute carrier family 6-member 4a. Cotreatment either epinephrine or 5-HT, but not cortisol, able rescue TS-mediated hypo thigmotaxis seen larvae. Together, these results indicate that is essential only mediating hyperactivity also maintaining basal anxiogenic during stress. latter depends on

Язык: Английский

Процитировано

0
Probiotics as technological innovations in psychiatric disorders: patents and research reviews DOI Creative Commons
Alyne Almeida de Lima, Sthefane Silva Santos, Maria Ilma Araújo

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 24, 2025

Probiotics have shown promising results in treating anxiety and depression by modulating the gut-brain-microbiota axis using probiotics, which has motivated increasing commercial academic interest innovations probiotic market. This work explored innovation trends use of probiotics management depression, through a patent search performed Espacenet database. To expand discussion, an additional was on ClinicalTrials.gov ScienceDirect. Recently developed were deposited as pharmaceutical products (24.1%), functional foods (20.4%), or both (51.8%). Probiotic strains showed anxiolytic, antidepressant effects related to one more mechanisms including modulation neurotransmitters (61.1%), neuroendocrine mediators (35.2%) neuroinflammation oxidative stress (20.3%). The mainly Lactobacillus (48.1%) Bifidobacterium (38.9%) genera. In search, 1,945 scientific publications 11 clinical trials found. Despite efficacy observed preclinical studies, transitioning from discoveries patented is not always straightforward. review provides evidence for therapeutic applications novel technologies psychiatric disorders. It supports further studies exploring their benefits highlights need greater investment this area.

Язык: Английский

Процитировано

0
Interplay of G-proteins and Serotonin in the Neuroimmunoinflammatory Model of Chronic Stress and Depression: A Narrative Review DOI
Evgeni Gusev, Alexey Sarapultsev

Current Pharmaceutical Design, Год журнала: 2023, Номер 30(3), С. 180 - 214

Опубликована: Дек. 28, 2023

Introduction: This narrative review addresses the clinical challenges in stress-related disorders such as depression, focusing on interplay between neuron-specific and pro-inflammatory mechanisms at cellular, cerebral, systemic levels. Objective: We aim to elucidate molecular linking chronic psychological stress with low-grade neuroinflammation key brain regions, particularly roles of G proteins serotonin (5-HT) receptors. Methods: comprehensive literature employs systematic, narrative, scoping methodologies, combined approaches general pathology. It synthesizes current research shared signaling pathways involved responses neuroinflammation, including calcium-dependent mechanisms, mitogen-activated protein kinases, transcription factors like NF-κB p53. The also focuses role protein-coupled neurotransmitter receptors (GPCRs) immune responses, a detailed analysis how 13 14 types human 5-HT contribute depression neuroinflammation. Results: reveals complex interaction signals immunoinflammatory pathologies. highlights GPCRs canonical inflammatory mediators influencing both pathological physiological processes nervous tissue. Conclusion: proposed Neuroimmunoinflammatory Stress Model (NIIS Model) suggests that proinflammatory pathways, mediated by metabotropic ionotropic receptors, are crucial for maintaining neuronal homeostasis. Chronic mental can disrupt this balance, leading increased states contributing neuropsychiatric psychosomatic disorders, depression. model integrates traditional theories pathogenesis, offering understanding multifaceted nature condition.

Язык: Английский

Процитировано

6
Effectiveness of osteopathic manipulative applications on hypothalamic–pituitary–adrenal (HPA) axis in youth with major depressive disorder: a randomized double-blind, placebo-controlled trial DOI Creative Commons
Ömer Osman Pala, Seyit Çıtaker, Esra Güney

и другие.

Journal of Osteopathic Medicine, Год журнала: 2024, Номер 124(6), С. 267 - 275

Опубликована: Фев. 28, 2024

Abstract Context Osteopathic treatments regulate the neurovegetative system through joint mobilizations and manipulations, myofascial craniosacral techniques. Despite growing body of research, precise impact osteopathic medicine on autonomic nervous (ANS) is not yet fully elucidated. As to Kuchera's techniques, stimulation sympathetic trunk prevertebral ganglia contributed harmonization activity. However, potential relationships between (SNS) hypothalamic–pituitary–adrenal (HPA) axis largely remain uncertain warrant further exploration. Objectives This study was designed evaluate effectiveness (OSH) SNS HPA in youth with major depressive disorder (MDD). Methods The included 39 youths aged 15–21 years diagnosed MDD. participants were randomly assigned into either OSH or placebo group. Stimulation performed truncus group a lighter touch shorter duration similar areas. Each participant completed Beck Depression Inventory (BDI) State Trait Anxiety (SAI TAI) before application. Blood pressure (BP) pulse measurements made, saliva samples taken before, immediately after, 20 min after Results baseline BDI (p=0.617) TAI (p=0.322) scores both groups. Although SAI decreased groups postintervention, no statistically significant difference found two Subjects who received had decrease α-amylase level (p=0.028) an increase cortisol (p=0.009) procedure. Conclusions Following application depressed youth, activity may decrease, whereas increase. Future studies examine therapeutic efficacy repeated applications individuals.

Язык: Английский

Процитировано

2
Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2 knockout model for the study of psycho-obstetric risk DOI
Serena B. Gumusoglu,

Michaela Kiel,

Aleigha Gugel

и другие.

Neuropsychopharmacology, Год журнала: 2023, Номер 49(5), С. 864 - 875

Опубликована: Окт. 17, 2023

Язык: Английский

Процитировано

4
Chemogenetic activation of PVN CRH neurons disrupts the estrous cycle and LH dynamics in female mice DOI Creative Commons

Junru Yu,

Xiao-Feng Li, Krasimira Tsaneva‐Atanasova

и другие.

Frontiers in Endocrinology, Год журнала: 2024, Номер 14

Опубликована: Янв. 9, 2024

The impact of stress on reproductive function is significant. Hypothalamic paraventricular nucleus (PVN) corticotrophin-releasing hormone (CRH) plays a major role in regulating the response. Understanding how hypothalamic-pituitary-adrenal (HPA) axis and hypothalamic-pituitary-gonadal (HPG) interact crucial for comprehending can lead to dysfunction. However, whether influences via modulating PVN CRH or HPA sequelae not fully elucidated.

Язык: Английский

Процитировано

1