Disrupted basolateral amygdala circuits supports negative valence bias in depressive states

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 19, 2024

Negative bias is an essential characteristic of depressive episodes leading patients to attribute more negative valence environmental cues. This affects all levels information processing including emotional response, attention and memory, the development maintenance symptoms. In this context, pleasant stimuli become less attractive unpleasant ones aversive, yet related neural circuits underlying remain largely unknown. By studying a mice model for depression chronically receiving corticosterone (CORT), we showed in attribution olfactory that responds antidepressant drug. result paralleled alterations odor value assignment observed bipolar depressed patients. Given crucial role amygdala coding its strong link with depression, hypothesized basolateral (BLA) might support shift associated states. Contrary humans, where limits spatial resolution imaging tools impair easy segmentation, recently unravelled specific BLA implicated positive could be studied mice. Combining CTB rabies-based tracing ex vivo measurements neuronal activity, demonstrated supported by disrupted activity during Chronic CORT administration induced decreased recruitment BLA-to-NAc neurons preferentially involved encoding, while increasing BLA-to-CeA encoding. Importantly, dysfunction was dampened chemogenetic hyperactivation neurons. Moreover, altered correlated durable presynaptic connectivity changes coming from paraventricular nucleus thalamus, as orchestrating amygdala. Together, our findings suggest states provide new avenues translational research understand mechanisms treatment efficacy.

Язык: Английский

Biased information routing through the basolateral amygdala, altered valence processing, and impaired affective states associated with psychiatric illnesses

Biological Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский