Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex DOI

Stephanie Schimmer,

Arthur Lefèvre, Julia Lebedeva

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 17, 2024

ABSTRACT The hypothalamic neuropeptide oxytocin is best known for its prosocial behavioral effects. However, the precise anatomical and cellular targets in cortex during social behavior remain elusive. Here we show that neurons project directly to medial prefrontal where evoked axonal release facilitates behaviors adult female rats. In conjunction, report local receptor (OTR + ) expressing cells are predominantly interneurons whose activation promotes interaction. particular, a state of food deprivation, this inhibitory neuronal subpopulation shifts preference from appetitive stimuli towards stimulus. We further demonstrate these OTR inhibits principal specifically projecting basolateral amygdala, thus providing putative mechanism selective action sociability promoting cortical network.

Язык: Английский

Evolution of Neuropeptide Signaling: From a Single Cell to Mammals DOI
Quirin Krabichler, Valery Grinevich

Masterclass in neuroendocrinology, Год журнала: 2025, Номер unknown, С. 3 - 43

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Oxytocin facilitates social behavior of female rats via selective modulation of interneurons in the medial prefrontal cortex DOI

Stephanie Schimmer,

Arthur Lefèvre, Julia Lebedeva

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 17, 2024

ABSTRACT The hypothalamic neuropeptide oxytocin is best known for its prosocial behavioral effects. However, the precise anatomical and cellular targets in cortex during social behavior remain elusive. Here we show that neurons project directly to medial prefrontal where evoked axonal release facilitates behaviors adult female rats. In conjunction, report local receptor (OTR + ) expressing cells are predominantly interneurons whose activation promotes interaction. particular, a state of food deprivation, this inhibitory neuronal subpopulation shifts preference from appetitive stimuli towards stimulus. We further demonstrate these OTR inhibits principal specifically projecting basolateral amygdala, thus providing putative mechanism selective action sociability promoting cortical network.

Язык: Английский

Процитировано

0