Prevalence of EBV, HHV6, HCMV, HAdV, SARS-CoV-2, and Autoantibodies to Type I Interferon in Sputum from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
Viruses,
Год журнала:
2025,
Номер
17(3), С. 422 - 422
Опубликована: Март 14, 2025
An
exhausted
antiviral
immune
response
is
observed
in
myalgic
encephalomyelitis/chronic
fatigue
syndrome
(ME/CFS)
and
post-SARS-CoV-2
syndrome,
also
termed
long
COVID.
In
this
study,
potential
mechanisms
behind
exhaustion
were
investigated.
First,
the
viral
load
of
Epstein–Barr
virus
(EBV),
human
adenovirus
(HAdV),
cytomegalovirus
(HCMV),
herpesvirus
6
(HHV6),
severe
acute
respiratory
coronavirus
2
(SARS-CoV-2)
was
determined
sputum
samples
(n
=
29)
derived
from
ME/CFS
patients
13),
healthy
controls
10),
elderly
4),
immunosuppressed
2).
Secondly,
autoantibodies
(autoAbs)
to
type
I
interferon
(IFN-I)
analyzed
possibly
explain
impaired
immunity.
We
found
that
released
EBV
at
a
significantly
higher
level
compared
(p
0.0256).
HHV6
present
~50%
all
participants
same
level.
HAdV
detected
two
cases
with
immunosuppression
ME/CFS,
respectively.
HCMV
SARS-CoV-2
only
controls.
Notably,
anti-IFN-I
autoAbs
did
not
differ,
except
case
showing
an
increased
conclude
patients,
controls,
have
EBV.
IFN-I
cannot
dysfunction,
possible
exception
cases,
reported
SARS-CoV-2.
forward
additional
mechanisms,
such
as
evasion
effect
via
degradation
IFN-receptors,
may
be
which
demands
further
studies.
Язык: Английский
The reactivation of the various types of viruses following COVID-19 infection: a systematic review
Future Virology,
Год журнала:
2025,
Номер
unknown, С. 1 - 13
Опубликована: Март 27, 2025
Язык: Английский
Ultrasound-assisted preparation of sweet corn cob polysaccharide selenium nanoparticles alleviates symptoms of chronic fatigue syndrome
Food & Function,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 5, 2024
Preparation
optimization
of
U-SCPSeNPs
and
improvement
chronic
fatigue
syndrome
study.
Язык: Английский
Overlapping conditions in Long COVID at a multisite academic center
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 25, 2024
Many
patients
experience
persistent
symptoms
after
COVID-19,
a
syndrome
referred
to
as
Long
COVID
(LC).
The
goal
of
this
study
was
identify
novel
new
or
worsening
comorbidities
self-reported
in
with
LC.
Язык: Английский