Journal of Pineal Research,
Год журнала:
2024,
Номер
76(5)
Опубликована: Авг. 1, 2024
Abstract
Parkinson's
disease
affects
millions
of
people
worldwide,
and
without
significant
progress
in
prevention
treatment,
its
incidence
prevalence
could
increase
by
more
than
30%
2030.
Researchers
have
focused
on
targeting
sleep
the
circadian
system
as
a
novel
treatment
strategy
for
disease.
This
study
investigated
association
between
melatonin
receptor
agonists
disease,
using
Food
Drug
Administration
(FDA)
Adverse
Events
Reporting
System
(FAERS).
The
target
drugs
were
including
ramelteon,
tasimelteon,
agomelatine.
cases
defined
according
to
Medical
Dictionary
Regulatory
Activities
(MedDRA)
25.0;
Standardized
MedDRA
Query
(SMQ)
both
“narrow”
“broad”
preferred
terms
(PTs)
associated
with
(ramelteon,
agomelatine)
was
evaluated
reporting
odds
ratio.
Upon
analyzing
data
from
all
patients
registered
FAERS,
ramelteon
(ROR:
0.66,
95%
confidence
interval
[95%
CI]:
0.51–0.84)
tasimelteon
0.49,
CI:
0.38–0.62)
showed
negative
correlations
Conversely,
only
agomelatine
positively
correlated
2.63,
2.04–3.40).
These
results
suggest
that
among
agonists,
are
negatively
In
contrast,
shown
be
should
used
research
develop
fully
considering
limitations
spontaneous
system.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
Brain Research Bulletin,
Год журнала:
2024,
Номер
213, С. 110991 - 110991
Опубликована: Май 31, 2024
Neurodegenerative
diseases
such
as
Parkinson's
disease
(PD)
have
complex
pathogenetic
mechanisms.
Genetic,
age,
and
environmental
factors
are
all
related
to
PD.
Due
the
unclear
pathogenesis
of
PD
lack
effective
cure
methods,
it
is
urgent
find
new
targets
for
treating
patients.
Ferroptosis
a
form
cell
death
that
reliant
on
iron
exhibits
distinct
morphological
mechanistic
characteristics
compared
other
types
death.
It
encompasses
range
biological
processes,
including
iron/lipid
metabolism
oxidative
stress.
In
recent
years,
research
has
found
ferroptosis
plays
crucial
role
in
pathophysiological
processes
neurodegenerative
stroke.
Therefore,
also
closely
PD,
This
article
reviews
core
mechanisms
elucidates
correlation
between
ferroptosis.
addition,
compounds
emerged
years
exert
anti
effects
by
inhibiting
signaling
pathway
were
summarized.
I
hope
further
elaborate
relationship
through
review
this
article,
provide
strategies
developing
treatments
targeting
Journal of Pineal Research,
Год журнала:
2025,
Номер
77(1)
Опубликована: Янв. 1, 2025
Circadian
rhythm
disruption
(CRD),
stemming
from
sleep
disorders
and/or
shift
work,
is
a
risk
factor
for
reproductive
dysfunction.
CRD
has
been
reported
to
disturb
nocturnal
melatonin
signaling,
which
plays
crucial
role
in
female
reproduction
as
circadian
regulator
and
an
antioxidant.
The
hypothalamic-pituitary-ovarian
(HPO)
axis
regulates
reproduction,
with
luteinizing
hormone
(LH)
pulse
pattern
playing
pivotal
folliculogenesis
steroidogenesis.
However,
the
effect
of
on
HPO
involvement
remains
unclear.
Female
CBA/CaJ
mice
underwent
modeling,
involves
alternating
between
standard
light
conditions
8-h
advance
schedule
every
3
days
8
weeks,
whereas
control
were
maintained
under
12:12-h
light/dark
(LD)
cycle.
Subsequent
measurements
diurnal
levels,
LH
patterns
assessments
via
serial
tail-tip
blood
sampling
evaluations
ovarian
function
conducted.
altered
rhythms
wheel-running
activity
secretion
led
augmented
pattern,
evidenced
by
increased
frequency,
mean
pituitary
beta-subunit
(LHβ)
expression,
irregular
estrous
cycles,
abnormal
luteal
function,
endocrine
oxidative
stress.
Melatonin
treatment
(10
mg/kg/day
4
weeks)
significantly
improved
disorder
mice,
decreasing
enhanced
frequency
LHβ
expression.
These
findings
further
validated
using
vitro
LβT2
cell
perfusion
model.
Furthermore,
restored
scavenged
reactive
oxygen
species,
thereby
preventing
apoptosis
preserving
function.
This
study
offers
new
insights
into
impact
emphasizes
potential
supplementation
mitigating
its
effects
reproduction.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 13, 2025
The
pathogenesis
of
renal
fibrosis
is
related
to
blood
stasis,
and
the
method
promoting
circulation
removing
stasis
often
used
as
treatment
principle.
Danshen
injection
(DSI)
a
commonly
drug
for
in
clinic.
However,
whether
DSI
slows
progression
or
potential
mechanism
uncertain.
We
investigated
models
using
UUO
mice
TGF-β
stimulation
HK-2
cells.
Our
findings
revealed
that
Fer-1
alleviated
kidney
injury
by
ameliorating
morphology
pathological
vivo.
Besides,
inhibited
vivo
TGF-β-induced
Furthermore,
ferroptosis
was
lessened
under
treatment.
More
importantly,
active
ingredients
(danshensu,
salvianolic
acid
B,
protocatechuic
aldehyde,
caffeic
tanshinone
IIA)
could
bind
SIRT1.
protein
levels
SIRT1
GPX4
were
downregulated
accompanied
incremental
concentrations
Erastin,
which
repaired
intervention.
inhibition
owing
reversed
inhibitor
EX527.
Taken
together,
our
results
indicated
protect
against
attenuate
activating
SIRT1/GPX4
pathway.
It
expected
be
agent
treat
fibrosis.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 31, 2025
Neuronal
senescence
is
a
common
pathological
feature
of
various
neurodegenerative
diseases,
with
ferroptosis
playing
significant
role.
This
study
aims
to
investigate
the
role
ErbB4
receptor
activation
in
preventing
D-Galactose
(D-gal)-induced
neuronal
senescence.
Mice
subjected
D-gal-induced
aging
were
administered
small
molecule
agonist
(E4A),
identified
via
virtual
screening,
melatonin,
or
combination
both.
Behavioral
assessments
conducted
evaluate
therapeutic
efficacy
memory
and
cognitive
functions.
Immunofluorescence
staining,
western
blot,
biochemical
assays
primarily
employed
assess
changes
both
senescence-
ferroptosis-related
molecules
mouse
hippocampal
tissues
response
each
treatment.
Additionally,
HT22
cell
cultures
utilized
corroborate
vivo
findings.
The
targeted
by
E4A
significantly
ameliorated
behavioral
deficits
induced
D-gal
mice,
demonstrating
an
effect
comparable
that
natural
inhibitor
ferroptosis.
Both
melatonin
mitigated
neurons
mice.
was
evidenced
upregulation
Lamin
B1
downregulation
P53,
P21,
P16,
GFAP,
Iba-1
expression
levels.
Moreover,
treatment
markedly
decreased
protein
Nrf2
while
augmenting
promoter
TFRC.
These
alterations
partially
reversed
individual
administration
melatonin.
In
vitro
studies
further
corroborated
concurrently
markers
promoters.
However,
able
reverse
these
changes.
Erastin-induced
cells.
Our
findings
suggest
may
be
viable
strategy
for
treating
inhibiting
ferroptosis,
thereby
offering
potential
avenue
senescence-associated
diseases.
