Melatonin stabilizes atherosclerotic plaques: an association that should be clinically exploited DOI Creative Commons
Rüssel J. Reiter, Ramaswamy Sharma, Alejandro Romero

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Дек. 11, 2024

Atherosclerosis is the underlying factor in premature death of millions humans annually. The cause often a result rupture an atherosclerotic plaque followed by discharge associated molecular debris into vessel lumen which occludes artery leading to ischemia downstream tissue and morbidity or mortality individual. This most serious when it occurs heart (heart attack) brain (stroke). Atherosclerotic plaques are classified as either soft, rupture-prone, hard, resistant. Melatonin, production diminishes with age, has major actions converting soft hard plaques. Experimentally, melatonin reduces ingrowth capillaries from tunica media relieving pressure on plaque, reducing intraplaque hemorrhage limiting size necrotic core. Moreover, promotes formation collagen invading vascular smooth muscle cells strengthen crown making resistant rupture. Melatonin also powerful antioxidant anti-inflammatory agent such that oxidative damage tissues limits inflammation both contribute cap weakness. Additional benefits relative atherosclerosis inhibition adhesion molecules endothelial cell surface, invasion monocytes arterial intima, conversion M2 macrophages pro-inflammatory M1 macrophages. Given high physiological financial cost cardiac neural ischemic events, this information should be given priority clinical setting.

Язык: Английский

Melatonin stabilizes atherosclerotic plaques: an association that should be clinically exploited DOI Creative Commons
Rüssel J. Reiter, Ramaswamy Sharma, Alejandro Romero

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Дек. 11, 2024

Atherosclerosis is the underlying factor in premature death of millions humans annually. The cause often a result rupture an atherosclerotic plaque followed by discharge associated molecular debris into vessel lumen which occludes artery leading to ischemia downstream tissue and morbidity or mortality individual. This most serious when it occurs heart (heart attack) brain (stroke). Atherosclerotic plaques are classified as either soft, rupture-prone, hard, resistant. Melatonin, production diminishes with age, has major actions converting soft hard plaques. Experimentally, melatonin reduces ingrowth capillaries from tunica media relieving pressure on plaque, reducing intraplaque hemorrhage limiting size necrotic core. Moreover, promotes formation collagen invading vascular smooth muscle cells strengthen crown making resistant rupture. Melatonin also powerful antioxidant anti-inflammatory agent such that oxidative damage tissues limits inflammation both contribute cap weakness. Additional benefits relative atherosclerosis inhibition adhesion molecules endothelial cell surface, invasion monocytes arterial intima, conversion M2 macrophages pro-inflammatory M1 macrophages. Given high physiological financial cost cardiac neural ischemic events, this information should be given priority clinical setting.

Язык: Английский

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