BMC Oral Health, Год журнала: 2023, Номер 23(1)
Опубликована: Ноя. 19, 2023
To evaluate the effect of curcumin gel combined with scaling and root planing (SRP) on salivary procalcitonin in periodontitis treatment.
Язык: Английский
International Journal of Oral Science, Год журнала: 2022, Номер 14(1)
Опубликована: Март 2, 2022
Abstract Oral bacteria directly affect the disease status of dental caries and periodontal diseases. The dynamic oral microbiota cooperates with host to reflect information immunity metabolism through two-way communication along cavity systemic organs. is one most important interaction windows between human body environment. microenvironment at different sites in has microbial compositions regulated by complex signaling, hosts, external environmental factors. These processes may or health because certain states seem be related composition bacteria, destruction community In this review, we discussed emerging exciting evidence connections microbes multiple diseases, possible contribution microorganisms This review aims enhance interest on whole body, also improve clinician’s understanding role Microbial research dentistry potentially enhances our knowledge pathogenic mechanisms same time, continuous advances frontier field lead a tangible impact health.
Язык: Английский
Процитировано
361
Frontiers in Psychiatry, Год журнала: 2022, Номер 12
Опубликована: Янв. 27, 2022
The prevalence of anxiety, mood and trauma- stress-related disorders are on the rise; however, efforts to develop new effective treatment strategies have had limited success. To identify novel therapeutic targets, a comprehensive understanding disease etiology is needed, especially in context holobiont, i.e., superorganism consisting human its microbiotas. Much emphasis has been placed role gut microbiota development, exacerbation, persistence psychiatric disorders; data for oral limited. cavity houses second most diverse microbial community body, with over 700 bacterial species that colonize soft hard tissues. Periodontal diseases encompass group infectious inflammatory affect periodontium. Among them, periodontitis defined as chronic, multi-bacterial infection elicits low-grade systemic inflammation via release pro-inflammatory cytokines, well local invasion long-distance translocation periodontal pathogens. Periodontitis can also induce or exacerbate other chronic such atherosclerosis diabetes lead adverse pregnancy outcomes. Recently, pathogens implicated pathophysiology neuropsychiatric (such depression schizophrenia), dysregulation immune system plays an integral these disorders. This review will discuss associated Epidemiological individuals be presented, followed by discussion microbiological immunological links between central nervous system. Pre-clinical clinical findings related phenotypes reviewed, bi-directionality oral-brain axis. Lastly, we focus target future interventions alleviate symptoms debilitating
Язык: Английский
Процитировано
77
Mediators of Inflammation, Год журнала: 2023, Номер 2023, С. 1 - 19
Опубликована: Май 13, 2023
During recent years, considerable progress has been made in understanding the etiopathogenesis of periodontitis its various forms and their interactions with host. Furthermore, a number reports have highlighted importance oral health disease systemic conditions, especially cardiovascular diseases diabetes. In this regard, research attempted to explain role promoting alteration distant sites organs. Recently, DNA sequencing studies revealed how infections can occur such as colon, reproductive tissues, metabolic diseases, atheromas. The objective review is describe update emerging evidence knowledge regarding association between analyse that reported risk factor for development order provide better possible shared etiopathogenetic pathways different diseases.
Язык: Английский
Процитировано
63
Periodontology 2000, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
Abstract To provide a comprehensive and updated mapping of observational studies assessing the relationship between periodontitis systemic diseases through bibliometric visual analysis. A search was conducted using Web Science database, covering period 1989 to 2024. The Medical Subject Headings (MeSH) from US National Library Medicine used categorize conditions, focusing on terms unrelated stomatognathic diseases. analysis included keyword co‐occurrence mapping, co‐authorship, bibliographic coupling, co‐citation Quality indicators such as silhouette score, modularity, centrality were considered assess network's quality. research strategy identified 6106 records, which 1519 met inclusion criteria. revealed that 46.73% literature topic published in last 5 years annual publication trend peaked 2023. Nutritional & Metabolic Diseases ( n = 398), Cardiovascular 335), Female Urogenital Pregnancy Complications 244), Musculoskeletal 182) most representative categories associated with periodontitis. co‐cited journals Journal Periodontology 1412), Clinical 1343), Dental Research 940), 2000 849). USA, China, Brazil, Sweden countries contributed number publications. present study growing evaluating association diseases, highlighting negative impact plethora conditions rising translational interest this relationship. With an aging population, is expected affect people coming decades, presenting significant challenges public health. Improved knowledge is, therefore, essential enable more care, preventive strategies, optimal oral health for patients
Язык: Английский
Процитировано
12
Journal of Periodontology, Год журнала: 2021, Номер 93(1), С. 135 - 145
Опубликована: Май 19, 2021
Nod-like receptor family pyrin domain-containing protein-3 (NLRP3) complex inflammasome has potentially been shown to play an important role in the development of periodontitis and diabetes. The objective this study was analyze association between serum salivary NLRP3 concentrations patients with type-II diabetes mellitus (DM) evaluate whether influenced by potential confounders.For present study, a cohort healthy controls (n = 32), 34), DM 33), combination + 34) were enrolled. Patients characterized on basis their periodontal status analyzed for demographic characteristics, mediators, NLRP3. A uni- multivariate model established periodontitis, DM, CRP concentrations.In comparison controls, (serum, P 0.003; saliva 0.012) 0.028; saliva, 0.003) had elevated concentrations. regression showed that (P 0.029) HDL-cholesterol significant predictors whereas 0.036) NLRP3.The results higher DM. Periodontitis demonstrated be predictor both
Язык: Английский
Процитировано
85
Journal of Periodontal Research, Год журнала: 2022, Номер 58(1), С. 165 - 174
Опубликована: Дек. 8, 2022
Abstract Background and Objective Recent emerging evidence has shown that microRNA (miRNAs) is involved in several epigenetic processes linked with periodontitis, increased oxidative stress cardiovascular disease (CVD). The present study aimed to assess the impact of periodontitis on gingival crevicular fluid (GCF) miRNAs expression associated CVD risk evaluate possible confounders influenced this association. Materials Methods For study, healthy controls ( n = 28) subjects 28), 30) + 29) were enrolled. All underwent regular periodontal examinations blood sampling. In addition, GCF sampling was performed, 7a‐5p, 21‐3p, 21‐5p, 100‐5p, 125‐5p, 200b‐3p, 200b‐5p analyzed using a real‐time quantitative polymerase chain reaction (RT‐PCR). Results results showed presented significantly different compared subjects. More specifically, CVD, higher miRNA p < .05) lower 125‐5p levels .05). Furthermore, multivariate regression analysis evidenced (miRNA 100‐5p) inflamed surface area (PISA) 200b‐3p) significant predictors concentration Conclusion highlighted group than its extent revealed as risk.
Язык: Английский
Процитировано
62
Journal of Periodontology, Год журнала: 2023, Номер 94(12), С. 1414 - 1424
Опубликована: Июль 11, 2023
N-terminal portion of the B-type natriuretic propeptide (NT-proBNP) has potentially been shown to play an important role in development periodontitis and cardiovascular disease (CVD). This study evaluated efficacy periodontal treatment on NT-proBNP related CVD biomarkers explored whether subjects harboring high at baseline showed increased clinical benefits with non-surgical performed full-mouth scaling root planing (FM-SRP) 6-month follow-up.
Язык: Английский
Процитировано
33
Journal of Healthcare Engineering, Год журнала: 2023, Номер 2023(1)
Опубликована: Янв. 1, 2023
The World Health Organization reports that heart disease is the most common cause of death globally, accounting for 17.9 million fatalities annually. fundamentals a cure, it thought, are important symptoms and recognition illness. Traditional techniques facing many challenges, ranging from delayed or unnecessary treatment to incorrect diagnoses, which can affect progress, increase bill, give more time spread harm patient's body. Such errors could be avoided minimized by employing ML AI techniques. Many significant efforts have been made in recent years computer-aided diagnosis detection applications, rapidly growing area research. Machine learning algorithms especially CAD, used detect patterns medical data sources make nontrivial predictions assist doctors clinicians making timely decisions. This study aims develop multiple methods machine using UCI set based on individuals' attributes aid early cardiovascular disease. Various evaluate review results dataset. proposed had highest accuracy, with random forest classifier achieving 96.72% extreme gradient boost 95.08%. will doctor taking appropriate actions. technology only able determine whether not person has issue. severity cannot determined this method.
Язык: Английский
Процитировано
27
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(11), С. 5456 - 5456
Опубликована: Май 21, 2021
During the last few decades, it has been established that messenger ribonucleic acid (mRNA) transcription does not inevitably lead to protein translation, but there are numerous processes involved in post-transcriptional regulation, which is a continuously developing field of research. MicroRNAs (miRNAs) group small non-coding RNAs, negatively regulate expression and implicated several physiological pathological mechanisms. Aberrant miRNAs triggers dysregulation multiple cellular innate adaptive immune responses. For many years, was thought acted only within cell they were synthesised, but, recently, have found outside cells bound lipids proteins, or enclosed extracellular vesicles, namely exosomes. They can circulate throughout body, transferring information between altering gene recipient cells, as fuse with be internalised by cells. Numerous studies on conducted order identify possible biomarkers used diagnosis periodontal disease. However, therapeutic agents, single target genes influence regulatory networks. The aim this review examine molecular role exosomes pathophysiology disease evaluate clinical future implications for personalised therapeutical approach.
Язык: Английский
Процитировано
43
BMC Oral Health, Год журнала: 2021, Номер 21(1)
Опубликована: Май 5, 2021
The gold standard in treatment of periodontitis is mechanical removing dental biofilm but using local delivery drugs as adjunctive to SRP widely used modulate inflammatory host and eradicate microbes. Tea tree oil (TTO) has a broad-spectrum antimicrobial, anti-inflammatory, antifungal, antiviral, antioxidant effect. This study aimed assess clinically biochemically the effect intrapocket application TTO (Melaleuca alternifolia) gel scaling root planing (SRP) stage 2 (moderate) correlate biochemical levels with clinical response.
Язык: Английский
Процитировано
40