Inflammation, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 29, 2024
Язык: Английский
Periodontology 2000, Год журнала: 2024, Номер 95(1), С. 203 - 219
Опубликована: Июнь 1, 2024
In the era of personalized/precision health care, additional effort is being expended to understand biology and molecular mechanisms disease processes. How these are affected by individual genetics, environmental exposures, behavioral choices will encompass an expanding role in future optimally preventing treating diseases. Considering saliva as important biological fluid for analysis inform oral detection/description continues expand. This review provides overview a diagnostic features various biomarkers that have been reported. We emphasize use salivary periodontitis transport reader through extant literature, gaps knowledge, structured approach toward validating determine utility periodontitis. A summation findings support likelihood panel including both host molecules specific microorganisms be required most effectively identify risk early transition disease, ongoing activity, progression, response standard periodontal therapy. The goals would develop predictive algorithms serve adjunctive tools which provide clinician patient information making informed clinical decisions.
Язык: Английский
Процитировано
9
Clinical Implant Dentistry and Related Research, Год журнала: 2025, Номер 27(1)
Опубликована: Янв. 28, 2025
ABSTRACT Objective This cross‐sectional study aimed to investigate the salivary profile of inflammatory mediators in individuals with periodontal and peri‐implant disease as compared health. Materials Methods Saliva samples were collected from 155 participants (mean age 63.3 ± 11.4 years), comprising health ( N = 41), gingivitis and/or mucositis 18), periodontitis peri‐implantitis 96). Samples analyzed using multiplex‐immunoassay panel consisting tumor necrosis factor (TNF), interferon (IFN), interleukin (IL) superfamily, matrix metalloproteinases. Results The levels B‐cell activating (BAFF), sIL‐6Rβ, IFN‐β, sIL‐6Rα, sTNFR1, Pentraxin‐3 significantly higher patients healthy subjects. Furthermore, among investigated mediators, exhibited highest diagnostic potential (AUC 0.74) for distinguishing between subjects individuals. Conclusions Our findings demonstrated elevated BAFF, sTNF‐R1, comparison controls.
Язык: Английский
Процитировано
1
Advances in clinical chemistry, Год журнала: 2024, Номер unknown, С. 145 - 168
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
3
Advances in clinical chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Periodontal Research, Год журнала: 2024, Номер unknown
Опубликована: Дек. 2, 2024
ABSTRACT Aim Salivary content is regarded as a powerful diagnostic window for oral and systemic diseases the proteomic profile could be useful to distinguish between different periodontal conditions. The aim of present systematic review was assess distinctive salivary proteins identified through untargeted proteomics in periodontitis patients compared periodontally healthy gingivitis subjects, well provide qualitative methodological assessment current literature. Methods Relevant studies from Medline via PubMed, Scopus, Embase, Cochrane Library databases were retrieved answer following PECO question: “In systemically individuals, are there any differences protein expression profiles assessed with or subjects?” Moreover, utility markers sought targeted literature search further quantitative assessment. A modified version QUADAOMICS tool used quality included studies. Results After screening 461 relevant articles, total 13 selected. number discriminant ranged 2 4161. However, it possible identify that consistently over‐ under‐expressed at least 3 Among these, complement C3, profilin‐1, SA100A8, fibrinogen reported increased periodontitis, while cystatin‐SN leukocyte elastase inhibitor more elevated controls. Only 4 accuracy measures, SA100A8 showing an area under curve 0.71 (95% CI: 0.66–0.75) meta‐analysis. Conclusions Untargeted techniques some key biological molecules which periodontitis. These findings support novel candidate biomarkers high level heterogeneity methods reporting urge develop standardized protocols implemented this research field (PROSPERO CRD42022299826).
Язык: Английский
Процитировано
2
Nutrients, Год журнала: 2023, Номер 15(22), С. 4805 - 4805
Опубликована: Ноя. 16, 2023
The present study aims to test whether probiotics protect against experimental gingivitis incited by 14 days of oral hygiene neglect and/or subsequently support the restoration homeostasis. Eighty systemically and orally healthy participants refrained from procedures for days, followed with regular procedures. Additionally, consumed either (n = 40) or placebo throughout trial. At baseline, day 14, 28, supragingival plaque score bleeding-on-probing percentage (BOP %) were registered, saliva samples collected. microbiota was characterized using 16S sequencing, analyzed levels pro-inflammatory cytokines proteases. relative abundance Lautropia (p 0.014), Prevotella 0.046), Fusobacterium 0.033), Selenomonas 0.0078) genera significantly higher in group compared group, while Rothia 0.047) species associated group. Streptococcus sanguinis Campylobacter gracilis No difference observed salivary cytokines, albumin, any enzyme activity. suggests that resilience resolution period after gingivitis.
Язык: Английский
Процитировано
5
Oral Diseases, Год журнала: 2023, Номер 30(4), С. 2254 - 2261
Опубликована: Июль 10, 2023
Abstract Objectives Toll‐like receptor‐2 (TLR2) signalling pathway is involved in the regulation of interleukin (IL)‐33 and its receptor suppression tumorigenicity‐2 (ST2). This study aimed to compare salivary IL‐33 soluble ST2 (sST2) levels periodontitis patients with those periodontally healthy individuals relation their TLR2 rs111200466 23‐bp insertion/deletion polymorphism within promoter region. Materials Methods Unstimulated saliva samples were collected, periodontal parameters recorded from 35 44 patients. Non‐surgical treatments applied patients, sample collections clinical measurements repeated 3 months following therapy. Salivary sST2 measured enzyme‐linked immunosorbent assay kits, was detected by polymerase chain reaction. Results Elevated ( p = 0.007) 0.020) observed comparison controls. declined 3‐months treatment < 0.001). Increased found be associated periodontitis, no significant polymorphism. Conclusion Periodontitis, but not polymorphism, elevated possibly levels, effective reducing levels.
Язык: Английский
Процитировано
2
Journal of Periodontology, Год журнала: 2023, Номер 95(7), С. 673 - 681
Опубликована: Дек. 13, 2023
Host-modulating therapy is a possible treatment for individuals that respond poorly to conventional periodontal therapy. B cells, abundant in periodontitis lesions, require the cytokines cell-activating factor (BAFF) and A proliferation-inducing ligand (APRIL) survival maturation. Although mRNA levels of BAFF APRIL are increased tissue from it unknown if resident cells express and/or during inflammation. In this study, we aim analyze expression human gingival fibroblasts after stimulation with proinflammatory cytokines. Furthermore, perform protein analysis tissues serum patients healthy controls.
Язык: Английский
Процитировано
2
Nutrients, Год журнала: 2023, Номер 15(22), С. 4810 - 4810
Опубликована: Ноя. 17, 2023
The aim was to test if probiotics counteract oral dysbiosis during 14 days of sugar stress and subsequently help restore homeostasis. Eighty healthy individuals received either (n = 40) or placebo lozenges for 28 rinsed with a 10% sucrose solution 6-8 times the initial trial. Saliva supragingival samples were collected at baseline, day 14, 28. analyzed levels pro-inflammatory cytokines, albumin, salivary enzyme activity. microbiota characterized according Human Oral Microbiome Database. After stress, relative abundance Porphyromonas species significantly higher (p 0.03) remained elevated in probiotic group compared 0.004). At 28, Kingella 0.03). Streptococcus gordinii Neisseria elongata associated on while sobrinus On albumin level lower group. present study demonstrates potential stabilizing effect mediated by consumption short-term stress.
Язык: Английский
Процитировано
1
Inflammation, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 29, 2024
Язык: Английский
Процитировано
0