Exosomes in Oral Diseases: Mechanisms and Therapeutic Applications
Drug Design Development and Therapy,
Год журнала:
2025,
Номер
Volume 19, С. 457 - 469
Опубликована: Янв. 1, 2025
Exosomes,
small
extracellular
vesicles
secreted
by
various
cells,
play
crucial
roles
in
the
pathogenesis
and
treatment
of
oral
diseases.
Recent
studies
have
highlighted
their
involvement
orthodontics,
periodontitis,
squamous
cell
carcinoma
(OSCC),
hand,
foot,
mouth
disease
(HFMD).
Exosomes
a
positive
effect
on
inflammatory
environment
cavity,
remodeling
regeneration
tissues,
offer
promising
therapeutic
options
for
bone
periodontal
tissue
restoration.
In
OSCC
tumor-derived
exosomes
promote
cancer
progression
through
proliferation,
migration,
invasion,
angiogenesis,
serve
as
potential
biomarkers
early
diagnosis
prognosis.
Additionally,
engineered
constructed
specifically
based
exosome
properties
hold
great
promise
targeted
drug
delivery
regenerative
therapies
such
orthodontics
healing.
With
continued
research,
improving
diseases,
advancing
personalized
therapies.
Язык: Английский
Extracellular Vesicles in Periodontitis: Pathogenic Mechanisms and Therapeutic Potential
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 1317 - 1331
Опубликована: Янв. 1, 2025
Periodontitis
is
a
prevalent
yet
frequently
overlooked
oral
disease
that
linked
to
range
of
systemic
conditions.
Although
basic
treatment
and
periodontal
surgery
can
alleviate
the
symptoms
periodontitis
certain
extent,
severe
tissue
defects
or
refractory
cases
not
effective.
Extracellular
vesicles
(EVs)
are
subcellular
lipid
bilayer
particles
come
from
variety
sources
in
biological
fluids
vertebrates.
They
play
key
role
intercellular
communication
by
transporting
multiple
signaling
molecules.
Recent
research
has
indicated
EVs
derived
pathogens
trigger
periodontitis,
exacerbate
damage,
potentially
disseminate
other
parts
body,
leading
Conversely,
extracellular
dental
stem
cells
(DSCs)
have
demonstrated
ability
regulate
local
immune
environment
foster
regeneration
repair
tissues,
positioning
them
as
promising
candidate
for
cell-free
therapeutic
approaches
periodontitis.
This
review
aims
summarize
latest
on
involvement
different
pathogenesis
especially
systematically
elucidate
mechanism
secreted
periodontitis-related
diseases
first
time.
By
uncovering
these
complex
regulatory
processes,
new
more
effective
be
explored
battle
against
its
associated
diseases.
Язык: Английский
Youthful small extracellular vesicles restore the function and reparative capacity of inflammatory-impaired periodontal ligament stem cells via delivering protein biglycan for bone regeneration
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 24, 2024
Regenerating
inflamed
bone
defects
represents
a
severe
clinical
challenge
due
to
the
undesirable
inflammatory
microenvironment.
The
stimulus
poses
weighty
threat
regenerative
capacity
of
endogenously
derived
mesenchymal
stem
cells
(MSCs),
which
are
mainly
responsible
for
osteogenic
differentiation,
thereby
resulting
in
compromised
endogenous
formation.
Consequently,
alleviating
biological
characteristics
inflammatory-impaired
MSCs
is
crucial
promoting
regeneration.
Nano-sized
small
extracellular
vesicles
(sEVs)
have
emerged
as
promising
therapeutic
tools
orchestrate
fate
their
intrinsic
biocompatibility
and
encapsulated
bioactive
contents.
In
present
study,
we
extracted
sEVs
from
youthful
adult
dental
pulp
explored
ability
recover
inflammation-compromised
periodontal
ligament
(IPDLSCs).
results
indicated
that
both
types
were
capable
facilitating
IPDLSCs
osteogenesis.
However,
young
exhibited
more
robust
potential
at
lower
concentration
compared
sEVs.
Mechanically,
enhanced
expression
morphogenetic
protein
4
(BMP4)
via
delivering
Biglycan,
correspondingly
promoted
capability
IPDLSCs.
Collectively,
our
findings
emphasized
hold
enormous
rescue
inherent
function
competence
inflammation-impaired
MSCs,
shedding
light
on
prospects
infected
Язык: Английский
Severe Periodontitis is Associated With Recurrent Cardiovascular Events—A 10‐Year Longitudinal Cohort Study
Journal of Periodontal Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 22, 2024
ABSTRACT
Aim
The
study
aimed
to
elucidate
a
putative
association
between
severe
periodontitis
and
the
incidence
of
recurrent
cardiovascular
events
in
patients
with
disease
(CVD)
within
10
years
after
their
initial
hospitalisation.
Methods
A
cohort
1002
stationary
angiographically
proven
CVD
was
included.
They
were
examined
regarding
prevalence
(≥
30%
teeth
proximal
attachment
loss
≥
5
mm),
probing
depth,
clinical
loss,
bleeding
on
probing,
number
missing
oral
care
habits.
Recurrent
summarised
as
combined
end
point
(myocardial
infarction,
stroke/transitory
ischemic
attack,
death
caused
by
stroke).
Survival
analyses
carried
out
10‐year
follow‐up
period.
Hazard
ratios
(HRs)
adjusted
for
known
cardiac
risk
factors
using
Cox
regression.
Results
completed
792
patients.
overall
42.8%.
Severe
associated
(adjusted
hazard
ratio
[HR]
=
1.26,
95%
confidence
interval
[CI]
1.0–1.58
Standard
error
[SE]
0.11),
whereas
both,
tooth
brushing
more
than
once
day
HR
0.74,
CI
0.57–0.97,
SE
0.13)
performing
interdental
hygiene
0.71,
0.52–0.99,
0.16)
decreased
this
risk.
Conclusions
is
factor
events.
Trial
Registration
ClinicalTrials.gov
identifier:
NCT01045070
Язык: Английский
Exosomal miR‐155‐5p Facilitates Lipopolysaccharide Transport and Foam Cell Formation: A Novel Link Between Periodontitis and Atherosclerosis
Journal of Periodontal Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
ABSTRACT
Aim
To
investigate
the
role
of
lipopolysaccharide
(LPS)
from
Porphyromonas
gingivalis
and
miR‐155‐5p‐enriched
exosomes
in
formation
foam
cells
occurrence
carotid
atherosclerosis
(CAS).
Methods
The
CAS
tissue
samples
plasma
healthy
control
group
or
patients
undergoing
periodontitis
without
with
were
collected
at
Xuanwu
Hospital,
Capital
Medical
University.
expression
level
miR‐155‐5p
was
evaluated
by
immunofluorescent
analysis
qRT‐PCR.
Oil
red
O
staining
lipid
accumulation
assays
performed
to
explore
effects
LPS
on
mouse
macrophage
Raw264.7
human
monocytes
THP‐1.
levels
lipid‐regulated
genes
detected
Dual‐luciferase
reporter
gene
assay
DET1
overexpressed
inhibited
used
verify
target
exosomal
miR‐155‐5p.
ApoE
−/−
mice
confirm
auxo‐action
vivo,
LAL
detect
content.
Results
higher
than
those
CAS.
significantly
increased
tissues
compared
Normal
tissues,
associated
tissues.
MiR‐155‐5p‐enriched
accelerated
macrophage‐like
promoted
activity
lipid‐accumulation
targeting
.
In
mice,
circulating
captured
LPS,
LPS‐laden
conferred
access
for
triggering
Conclusion
enriched
capture
escort
atherosclerotic
sites,
licensing
thus
promoting
Язык: Английский