Free Radical Biology and Medicine, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Journal of Periodontology, Год журнала: 2024, Номер unknown
Опубликована: Май 2, 2024
Growing evidence suggests the type of periodontal treatment could differentially influence reduction key cardiovascular risk mediators in periodontitis patients. This randomized, controlled clinical trial compared impact minimally invasive non-surgical therapy (MINST) with quadrant-wise subgingival instrumentation (Q-SI) on C-reactive protein (CRP) together lipoprotein-associated phospholipase A
Язык: Английский
Процитировано
24
Periodontology 2000, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
Abstract To provide a comprehensive and updated mapping of observational studies assessing the relationship between periodontitis systemic diseases through bibliometric visual analysis. A search was conducted using Web Science database, covering period 1989 to 2024. The Medical Subject Headings (MeSH) from US National Library Medicine used categorize conditions, focusing on terms unrelated stomatognathic diseases. analysis included keyword co‐occurrence mapping, co‐authorship, bibliographic coupling, co‐citation Quality indicators such as silhouette score, modularity, centrality were considered assess network's quality. research strategy identified 6106 records, which 1519 met inclusion criteria. revealed that 46.73% literature topic published in last 5 years annual publication trend peaked 2023. Nutritional & Metabolic Diseases ( n = 398), Cardiovascular 335), Female Urogenital Pregnancy Complications 244), Musculoskeletal 182) most representative categories associated with periodontitis. co‐cited journals Journal Periodontology 1412), Clinical 1343), Dental Research 940), 2000 849). USA, China, Brazil, Sweden countries contributed number publications. present study growing evaluating association diseases, highlighting negative impact plethora conditions rising translational interest this relationship. With an aging population, is expected affect people coming decades, presenting significant challenges public health. Improved knowledge is, therefore, essential enable more care, preventive strategies, optimal oral health for patients
Язык: Английский
Процитировано
12
Clinical Oral Implants Research, Год журнала: 2025, Номер unknown
Опубликована: Янв. 25, 2025
ABSTRACT Objectives To evaluate the treatment of peri‐implant mucositis (PM) using a nonsurgical submarginal instrumentation (NSPI) with or without chlorhexidine (CHX) solutions. Methods Fifty‐six patients (28 per group) were randomly assigned to test (NSPI + 0.12% mouthwash and subgingival CHX irrigation plus tongue brushing 1% gel) control group placebo gel). At baseline, 1, 3, 6 months, bleeding on probing (BOP), pocket depth (PPD), modified gingival index (mGI), plaque (mPlI), full‐mouth score (FMPS), (FMBS), proportions Aggregatibacter actinomycetemcomitans , Porphyromonas gingivalis Tannerella forsythia Treponema denticola recorded. The BOP reduction was set as primary outcome. Data analyzed assess at 6‐month follow‐up identify significant predictors implant‐site through mixed generalized linear regression. Results After months in both groups, BOP, PD, mPlI, mGI, FMBS, FMPS noted ( p < 0.05). However, more effective than controls reducing median (∆values control/test: 39.3% [95% CI 37.4–42.3] vs. 48.7 46.5–51.2], = 0.044), well mPlI 0.041) proportion 0.039). Moreover, implant‐sites significantly influenced by 0.001), history periodontitis 0.003), high number cigarettes/day 0.002), 0.021) 0.032). Conclusions NSPI showed better results compared reduction. T. negatively PM‐treated patients.
Язык: Английский
Процитировано
4
Metabolites, Год журнала: 2025, Номер 15(1), С. 35 - 35
Опубликована: Янв. 9, 2025
Periodontitis, a chronic multifactorial inflammatory condition of the periodontium, is originated by dysbiotic oral microbiota and negatively correlated with several systemic diseases. The low-chronic burden gingival inflammation not only exacerbates periodontitis but also predisposes individuals to spectrum age-related conditions, including cardiovascular diseases, neurodegenerative disorders, metabolic dysfunction, especially related ageing. In this regard, over local periodontal treatment, lifestyle modifications adjunctive therapies may offer synergistic benefits in ameliorating both health ageing populations. Elucidating intricate connections between senescence important for understanding health's implications Effective management strategies targeting senescent pathways novel avenues promoting healthy preventing morbidities. This review will analyze current literature about interplay periodontitis, dysbiosis, processes senescence, shedding light on their collective impact modulation accelerated Lastly, therapeutic dysbiosis mitigate its associated morbidities be discussed.
Язык: Английский
Процитировано
3
Journal of Periodontology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 16, 2024
Abstract Background To assess the available evidence on whether nonsurgical periodontal treatment (NSPT) improves arterial stiffness outcomes in patients with periodontitis (PD). Methods Following Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) guidelines population, intervention, comparison, outcomes, study design (PICOS) question, electronic databases were screened clinical interventional studies addressing impact of NSPT pulse wave velocity (PWV), carotid intima‐media thickness (CIMT), flow‐mediated dilatation (FMD) PD patients. Furthermore, research strategy was implemented using a hand search. Studies selected, data extracted by two independent reviewers. Random effects models applied to perform meta‐analysis, methodological index nonrandomized (MINORS) Cochrane Rob2 tools used risk bias. Results Fifteen articles finally included qualitative synthesis. Among them, eight single‐arm cohort met final inclusion criteria meta‐analysis. The analysis evidenced that one randomized trial (RCT) had low risk, three RCTs raised some concerns, high bias, while MINORS scores ranged from 9 14. meta‐analysis showed significantly impacted FMD ( p < 0.001) CIMT = 0.004), changes PWV not statistically significant. However, there heterogeneity among I 2 78% 62% CIMT). Conclusion Despite beneficial CIMT, due limitations, heterogeneity, it cannot be concluded is effective improving stiffness. Therefore, further are necessary achieve high‐quality effect Trial registration PROSPERO ID CRD42024501399. Plain Language Summary Periodontitis (PD) has been associated alterations related early endothelial dysfunction. Based noninterventional studies, this indicates may reduce cardiovascular disease PD. moderate derived thickness, trend observed velocity. Moreover, findings present characterized bias uncontrolled trials or limitations. more standardized protocols homogeneous needed elevate quality evidence.
Язык: Английский
Процитировано
11
Medicina, Год журнала: 2024, Номер 60(5), С. 773 - 773
Опубликована: Май 7, 2024
The regeneration of periodontal bone defects continues to be an essential therapeutic concern in dental biomaterials. Numerous biomaterials have been utilized this sector so far. However, the immune response and vascularity defect regions may disregarded when evaluating effectiveness for repair. Among several regenerative treatments, most recent technique situ tissue engineering stands out its ability replicate endogenous restorative processes by combining scaffold with particular growth factors. Regenerative medicine solutions that combine biomaterials/scaffolds, cells, bioactive substances attracted significant interest, particularly repair regeneration. Dental stem cells (DSCs) share same progenitor immunomodulatory properties as other types MSCs, because they are easily isolable, regarded desirable agents dentistry. Recent research has demonstrated DSCs sown on newly designed synthetic bio-material scaffolds preserve their proliferative capacity while exhibiting increased differentiation immuno-suppressive capabilities. As researchers discovered how short peptide sequences modify adhesion capacities activating or inhibiting conventional osteogenic pathways, became more effective at priming MSCs. In review, many components applied will examined, impact cellular biology/molecular genetics addressed updated.
Язык: Английский
Процитировано
10
iScience, Год журнала: 2025, Номер 28(4), С. 112182 - 112182
Опубликована: Март 7, 2025
Our meta-analysis aimed to evaluate the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes. PubMed, Cochrane Library, Embase, Web Science were comprehensively searched until 4 December 2024, 10 randomized controlled trials (RCTs) included. The results indicated that, compared control group, significantly reduced probing depth (PD) (SMD = -0.77, 95% confidence interval [CI] (-1.37, -0.16)) but did not reduce clinical attachment loss (CAL) -0.18, CI (-0.60, 0.23)), sites with glycated hemoglobin (HbA1c) 0.03, (-0.38, 0.43)), plaque index -0.37, (-0.80, 0.06)), bleeding on (BOP) -0.26, (-0.68, 0.16)), gingival 0.07, (-0.30, 0.44)). Subgroup analysis by different elicited treatment, chlorhexidine was effective reducing BOP% -0.55, (-0.90, -0.19)). finds that diabetes is limited.
Язык: Английский
Процитировано
1
Nano Letters, Год журнала: 2024, Номер 24(43), С. 13708 - 13717
Опубликована: Окт. 17, 2024
Reactive oxygen species (ROS)-responsive drug delivery systems possess immense potential for targeted and controlled release of therapeutics. However, the rapid responsiveness to ROS sustained antibacterial drugs are often limited by challenging microenvironment periodontitis. Integrating ROS-responsive with photocatalytic technologies presents a strategic approach overcome these limitations. Herein, pillararene-embedded covalent organic framework (PCOF) incorporating prodrug thioacetal (TA) has been developed treat This drug-loaded nanoplatform, namely TA-loaded PCOF, utilizes self-amplifying property enhance therapeutic efficacy. PCOFs demonstrate exceptional photosensitivity generation capabilities when employed as carriers. When exposed ROS, TA within nanoplatform was activated cleaved into cinnamaldehyde (CA), highly potent compound. By leveraging visible light activate site-specific infection targeting, PCOF effectively alleviated periodontitis, thereby advancing field systems.
Язык: Английский
Процитировано
8
Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)
Опубликована: Сен. 28, 2024
Язык: Английский
Процитировано
7
PLoS ONE, Год журнала: 2024, Номер 19(9), С. e0306983 - e0306983
Опубликована: Сен. 6, 2024
Objectives This study aims to systematically review the existing literature and critically appraise evidence of genome-wide association studies (GWAS) on periodontitis. also synthesise findings genetic risk variants periodontitis from included GWAS. Methods A systematic search was conducted PubMed, GWAS Catalog, MEDLINE, GLOBAL HEALTH EMBASE via Ovid for Only exploring single-nucleotide polymorphisms(SNPs) associated with were eligible inclusion. The quality assessed using Q-genie tool. Information such as population, ethnicity, genomic data source, phenotypic characteristics(definition periodontitis), methods(quality control, analysis stages) extracted. SNPs that reached conventional or suggestive significance level(5e-8 5e-06) extracted synthesized. Results total 15 good-quality (Q-genie scores ranged 38–50). There huge heterogeneities among studies. 11 identified (rs242016, rs242014, rs10491972, rs242002, rs2978951, rs2738058, rs4284742, rs729876, rs149133391, rs1537415, rs12461706) at significant level ( p<5x10 -8 ), 41 -6 but no common found between Three (rs4284742 [G], rs11084095 [A], rs12461706 [T]) three large same gene region–SIGLEC5. Conclusion showed high heterogeneity methodology used provided limited statistics, making identifying reliable challenging. clear guidance in dental research requirement expectation make statistics available other investigators are needed.
Язык: Английский
Процитировано
4