CONTINUUM Lifelong Learning in Neurology,
Год журнала:
2023,
Номер
29(4), С. 1188 - 1204
Опубликована: Авг. 1, 2023
This
article
provides
an
overview
of
the
growing
body
evidence
showing
bidirectional
relationships
between
sleep
and
various
neurologic
disorders.Mounting
demonstrates
that
disrupted
can
negatively
impact
disease
processes,
including
stroke,
multiple
sclerosis,
epilepsy,
neuromuscular
disorders
amyotrophic
lateral
headache
syndromes.
Abnormal
also
be
a
precursor
to
Alzheimer
neurodegenerative
states
such
as
Parkinson
dementia
with
Lewy
bodies.
Interventions
improve
treat
obstructive
apnea
may
play
vital
role
in
preventing
development
progression.Sleep
are
common
among
patients
disorders.
To
provide
comprehensive
care
conditions,
neurologists
must
ask
about
issues
warrant
further
diagnostic
testing,
treatment,
medicine
referral
when
indicated.
Sleep Medicine X,
Год журнала:
2023,
Номер
6, С. 100087 - 100087
Опубликована: Сен. 27, 2023
This
study
aimed
to
determine
the
frequency,
type,
and
correlates
of
a
broad
spectrum
sleep
disorders
in
adults
with
COVID-19
up
32
months
after
infection.We
conducted
national
online
survey
(Jun
2021-Dec
2022),
gathering
information
on
diagnosis,
acute
disease
course,
subsequent
development
from
1507
respondents
(mean
age
44.5
±
13.1
years,
64.1%
women).81.3%
(1223)
reported
at
least
one
difficulty
that
either
worsened
or
first
appeared
COVID-19.
Females
higher
number
symptoms
(2.03
1.44
versus
1.72
1.43
men,
p
<
0.0001).
Most
common
were
insomnia
(59.4%),
followed
by
night
sweats
(38.4%),
hypersomnolence
(33.3%),
vivid
dreams
nightmares
(26.4%),
restless
leg
syndrome
(RLS)
(22.8%),
sleep-related
breathing
(11.1%).
All
associated
more
severe
disease.
A
mild
decreasing
trend
persistence
longer
latency
since
infection
was
observed,
66.7%
reporting
half
their
present
3-5
infection,
compared
64.9%
6-8
months,
62.4%
9-11
(p
=
0.0427).
However,
among
those
12
over
persisted
69.5%.
The
frequency
increased
association
32.9%
0.001).
9.4%
(141)
new-onset
parasomnic
manifestations
infection.Our
research
shows
disturbances
are
persistent
manifestation
affects
large
proportion
population
deserves
careful
monitoring.
Neurology Clinical Practice,
Год журнала:
2024,
Номер
15(1)
Опубликована: Ноя. 7, 2024
Isolated
REM
sleep
behavior
disorder
(iRBD)
carries
increased
risk
of
neurodegenerative
parkinsonian
or
dementia
(NPD)
but
is
difficult
to
accurately
screen
for
in
the
community.
Health
care
data
offer
opportunity
identify
large
numbers
iRBD
cases
among
outpatients.
We
aimed
determine
positive
predictive
value
(PPV)
an
RBD
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 12, 2024
ABSTRACT
Background
REM
sleep
behavior
disorder
(RBD)
is
an
early
manifestation
of
alpha-synucleinopathy
in
many
cases.
Dream
enactment
(DEB),
the
clinical
hallmark
RBD,
has
etiologies
and
cannot
be
used
alone
to
predict
underlying
alpha-synucleinopathy.
We
compared
proportion
people
with
alpha-synucleinopathy,
as
measured
by
CSF
alpha-synuclein
seed
amplification
assay
(CSFasynSAA),
between
polysomnographic-confirmed
RBD
(RBD-PSG)
who
reported
DEB
on
a
questionnaire
were
further
selected
smell
testing
DAT-SPECT.
Methods
Participants
enrolled
Parkinson’s
Progression
Marker
Initiative
(PPMI)
≥60
years
old
without
diagnosis
disease.
had
either
RBD-PSG
or
self-reported
DEB.
Self-reported
participants
have
hyposmia
(<10
th
percentile
for
age/sex)
at
least
mild
DAT-SPECT
abnormality
(<100%
age/sex-expected).
CSFasynSAA
(DEB+Hypos).
also
underwent
DAT-SPECT;
we
determined
predictive
value
these
tests
regards
CSFasynSAA.
Results
was
positive
171/240
(71%)
%)
180/210
(86%)
DEB+Hypos
participants.
Among
RBD-PSG,
strongly
predicted
CSFasynSAA+
(PPV:
92%
[95%
CI
87%-97%]).
Smell
identification
more
accurate
than
predicting
(AUC
UPSIT:
0.89
0.84
–
0.94];
AUC
DAT-SPECT:
0.65
0.58
0.73]).
Conclusions
may
effective
scalable
method
identify
among
those
individuals
diagnosed
PSG,
improved
prediction
biomarker.
This
chapter
provides
a
broad
perspective
on
the
pandemic's
effects
sleep
and
sleep–wake
behavior
in
general
population.
Studies
these
topics
are
currently
largely
cross-sectional
national
online
survey
studies
or
small
patient-sample
studies,
except
for
few
multinational
large-scale
by
an
international
collaboration
initiative
ICOSS.
Changes
during
COVID-19
pandemic
included
prominent
delays
bedtimes
wake-up
times,
increased
duration,
overall
increase
problems.
Insomnia
symptoms,
dream
recall
frequency,
dream-enactment
behaviors,
nightmares
were
prevalent
pandemic.
Mental
health
symptoms
problems
reflected
as
decrease
quality
In
this
chapter,
we
consider
differences
between
circadian
types
sleep.
Of
different
types,
many
small-scale
one
study
showed
that
schedules
delayed,
especially
among
evening-types,
who
also
reported
duration.
Evening-types
had,
lockdown,
opportunity
to
break
away
from
misalignment
of
their
natural
diurnal
rhythms
choose
more
aligned
with
rhythms.
However,
since
evening-types
at
risk
mental
issues
already
before
pandemic,
flexibility
everyday
life
did
not
override
negative
An
large
population
sample
showed,
disturbances
poor
emphasized
moderated
financial
suffering
time
spent
confinement.
CONTINUUM Lifelong Learning in Neurology,
Год журнала:
2023,
Номер
29(4), С. 1188 - 1204
Опубликована: Авг. 1, 2023
This
article
provides
an
overview
of
the
growing
body
evidence
showing
bidirectional
relationships
between
sleep
and
various
neurologic
disorders.Mounting
demonstrates
that
disrupted
can
negatively
impact
disease
processes,
including
stroke,
multiple
sclerosis,
epilepsy,
neuromuscular
disorders
amyotrophic
lateral
headache
syndromes.
Abnormal
also
be
a
precursor
to
Alzheimer
neurodegenerative
states
such
as
Parkinson
dementia
with
Lewy
bodies.
Interventions
improve
treat
obstructive
apnea
may
play
vital
role
in
preventing
development
progression.Sleep
are
common
among
patients
disorders.
To
provide
comprehensive
care
conditions,
neurologists
must
ask
about
issues
warrant
further
diagnostic
testing,
treatment,
medicine
referral
when
indicated.
