Increased plasma nucleosomes are associated with severe sepsis in foals DOI Creative Commons

Emily Birckhead,

Sharanne Raidal, Shubhagata Das

и другие.

The Veterinary Journal, Год журнала: 2025, Номер unknown, С. 106297 - 106297

Опубликована: Янв. 1, 2025

Sepsis is a main cause of death in neonatal foals. While the syndrome not completely understood, sepsis dysregulated inflammatory response host to infection. It can be difficult diagnose because varying and non-specific clinical signs imperfect diagnostic tests. Increased circulating nucleosome levels have been detected humans animals with sepsis, but this has documented Nucleosomes are released extracellularly during neutrophil extracellular trap formation, as well from damaged dead cells. We analysed plasma samples clinically healthy (n = 16), sick non-septic 31) septic 36) foals using an enzyme-linked immunosorbent assay (ELISA) that targeted nucleosomes. Septic evidence hypoperfusion and/or organ dysfunction were classified severe 24). The objective was determine if increased particularly those sepsis. Our data identified on day study entry significantly compared all other There significant difference between or Foal groups age-matched factors associated nature may affected results. Further research larger numbers similar ages, would necessary analysis nucleosomes related biomarkers helpful adjuncts for assessment understanding equine

Язык: Английский

Increased plasma nucleosomes are associated with severe sepsis in foals DOI Creative Commons

Emily Birckhead,

Sharanne Raidal, Shubhagata Das

и другие.

The Veterinary Journal, Год журнала: 2025, Номер unknown, С. 106297 - 106297

Опубликована: Янв. 1, 2025

Sepsis is a main cause of death in neonatal foals. While the syndrome not completely understood, sepsis dysregulated inflammatory response host to infection. It can be difficult diagnose because varying and non-specific clinical signs imperfect diagnostic tests. Increased circulating nucleosome levels have been detected humans animals with sepsis, but this has documented Nucleosomes are released extracellularly during neutrophil extracellular trap formation, as well from damaged dead cells. We analysed plasma samples clinically healthy (n = 16), sick non-septic 31) septic 36) foals using an enzyme-linked immunosorbent assay (ELISA) that targeted nucleosomes. Septic evidence hypoperfusion and/or organ dysfunction were classified severe 24). The objective was determine if increased particularly those sepsis. Our data identified on day study entry significantly compared all other There significant difference between or Foal groups age-matched factors associated nature may affected results. Further research larger numbers similar ages, would necessary analysis nucleosomes related biomarkers helpful adjuncts for assessment understanding equine

Язык: Английский

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