International Journal of Biological Macromolecules, Год журнала: 2024, Номер 280, С. 135387 - 135387
Опубликована: Сен. 10, 2024
Язык: Английский
Molecules, Год журнала: 2023, Номер 28(3), С. 1068 - 1068
Опубликована: Янв. 20, 2023
Natural extracts have been and continue to be used treat a wide range of medical conditions, from infectious diseases cancer, based on their convenience therapeutic potential. products derived microbes, plants, animals offer broad variety molecules chemical compounds. are not only one the most important sources for innovative drug development animal human health, but they also an inspiration synthetic biology chemistry scientists towards discovery new bioactive compounds pharmaceuticals. This is particularly relevant in current context, where antimicrobial resistance has risen as global health problem. Thus, efforts being directed toward studying natural compounds’ composition potential generate drugs with better efficacy lower toxicity than existing molecules. Currently, methodologies analyze vitro activity determine suitability agents. Despite traditional technologies employed, technological advances contributed implementation methods able circumvent issues related analysis capacity, time, sensitivity, reproducibility. review produces updated conventional evaluate
Язык: Английский
Процитировано
33
European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 252, С. 115292 - 115292
Опубликована: Март 18, 2023
Язык: Английский
Процитировано
26
Vaccines, Год журнала: 2023, Номер 11(2), С. 228 - 228
Опубликована: Янв. 19, 2023
Influenza is a contagious infection in humans that caused frequently by low pathogenic seasonal influenza viruses and occasionally avian (AIV) of H5, H7, H9 subtypes. Recently, the clinical sector poultry has been confronted with many challenges, including limited number antiviral drugs rapid evolution drug-resistant variants. Herein, anti-influenza activities various plant-derived phytochemicals were investigated against highly A/H5N1 virus (HPAIV H5N1) human A/H1N1 (LPHIV H1N1). Out 22 tested phytochemicals, steroid compounds β-sitosterol β-sitosterol-O-glucoside have very potent activity predefined A (IAV). Both steroids could induce such affecting multiple stages during IAV replication cycles, viral adsorption major significant impact on directly cell-free status "viricidal effect". On molecular level, several docking studies suggested exhibited viricidal effects through blocking active binding sites hemagglutinin surface protein, as well showing inhibitory neuraminidase M2 proton channel activity. The phytoestrogen structural similarity form female sex hormone estradiol, this likely one determinants enables its derivative to control vitro. This promising O-glycoside derivative, according both vitro cheminformatics studies, recommend for further going preclinical phases efficient drug candidates.
Язык: Английский
Процитировано
21
Viruses, Год журнала: 2024, Номер 16(2), С. 218 - 218
Опубликована: Янв. 31, 2024
Most plants have developed unique mechanisms to cope with harsh environmental conditions compensate for their lack of mobility. A key part coping is the synthesis secondary metabolites. In addition role in plants' defense against pathogens, they also possess therapeutic properties diseases, and use by humans predates written history. Viruses are a class submicroscopic agents, incapable independent existence outside living host. Pathogenic viruses continue pose significant threat global health, leading innumerable fatalities on yearly basis. The medicinal as natural source antiviral agents has been widely reported literature past decades. Metabolomics powerful research tool identification plant metabolites potentials. It can be used isolate compounds capacities study biosynthetic pathways involved viral disease progression. This review discusses special focus metabolomics evidence supporting efficacy. Suggestions made optimization various methods characterizing bioactive subsequently understanding operation.
Язык: Английский
Процитировано
7
Archiv der Pharmazie, Год журнала: 2022, Номер 355(10)
Опубликована: Июнь 7, 2022
Abstract The severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection is linked with inflammatory disorders and the development of oxidative stress in extreme cases. Therefore, anti‐inflammatory antioxidant drugs may alleviate these complications. Ginkgo biloba L. folium extract (EGb) a herbal medicine containing various active constituents. This review aims to provide critical discussion on potential role EGb management coronavirus disease 2019 (COVID‐19). antiviral effect mediated by different mechanisms, including blocking SARS‐CoV‐2 3‐chymotrypsin‐like protease that provides trans‐variant effectiveness. Moreover, impedes pulmonary through diminution neutrophil elastase activity, release proinflammatory cytokines, platelet aggregation, thrombosis. Thus, can attenuate lung injury distress COVID‐19. In conclusion, offers being used as adjuvant symptomatic therapy. Nanosystems enabling targeted delivery, personalization, booster effects opportunity for use modern phytotherapy.
Язык: Английский
Процитировано
29
Pesticide Biochemistry and Physiology, Год журнала: 2022, Номер 188, С. 105225 - 105225
Опубликована: Сен. 9, 2022
Язык: Английский
Процитировано
21
Phytochemistry Reviews, Год журнала: 2023, Номер 22(3), С. 615 - 693
Опубликована: Март 12, 2023
Abstract Viral infections have always been the main global health challenge, as several potentially lethal viruses, including hepatitis virus, herpes and influenza affected human for decades. Unfortunately, most licensed antiviral drugs are characterized by many adverse reactions and, in long-term therapy, also develop viral resistance; these reasons, researchers focused their attention on investigating potential molecules from plants. Natural resources indeed offer a variety of specialized therapeutic metabolites that demonstrated to inhibit entry into host cells replication through regulation absorption, cell receptor binding, competition activation intracellular signaling pathways. Many active phytochemicals, flavonoids, lignans, terpenoids, coumarins, saponins, alkaloids, etc., identified candidates preventing treating infections. Using systematic approach, this review summarises knowledge obtained date vivo activity extracted plant matrices focusing mechanism action.
Язык: Английский
Процитировано
13
Molecular Pharmaceutics, Год журнала: 2023, Номер 20(8), С. 3698 - 3740
Опубликована: Июль 24, 2023
Human viral oncogenesis is a complex phenomenon and major contributor to the global cancer burden. Several recent findings revealed cellular molecular pathways that promote development initiation of malignancy when viruses cause an infection. Even, antiviral treatment has become approach eliminate infections prevent activation oncogenesis. Therefore, for better understanding, pathogenesis various oncogenic like, hepatitis virus, human immunodeficiency (HIV), papillomavirus (HPV), herpes simplex virus (HSV), Epstein-Barr (EBV), could be explored, especially, expand many potent antivirals may escalate apoptosis infected malignant cells while sparing normal healthy ones. Moreover, contemporary therapies, such as engineered antibodies agents targeting signaling cell biomarkers, inhibit This review elaborates advancements in both natural synthetic control The study also highlights challenges future perspectives using
Язык: Английский
Процитировано
12
Molecules, Год журнала: 2022, Номер 27(23), С. 8353 - 8353
Опубликована: Ноя. 30, 2022
A-type proanthocyanidins (PAC-As) are plant-derived natural polyphenols that occur as oligomers or polymers of flavan-3-ol monomers, such (+)-catechin and (−)-epicatechin, connected through an unusual double A linkage. PAC-As present in leaves, seeds, flowers, bark, fruits many plants, thought to exert protective roles against microbial pathogens, insects, herbivores. Consequently, when tested isolation, have shown several biological effects, antioxidant, antibacterial, immunomodulatory, antiviral activities. been observed fact inhibit replication different human viruses, both enveloped non-enveloped DNA RNA viruses proved sensible their inhibitory effect. Mechanistic studies revealed cause reduction infectivity viral particles they come contact with, a result propensity interact with virion surface capsid proteins envelope glycoproteins essential for attachment entry. As infections new virus outbreaks major public health concern, development effective Broad-Spectrum Antiviral Agents (BSAAs) can be rapidly deployable even future emerging is urgent priority. This review summarizes the activities mechanism action PAC-As, potential deployed BSAAs infections.
Язык: Английский
Процитировано
19
Pharmacological Reports, Год журнала: 2022, Номер 74(6), С. 1238 - 1254
Опубликована: Сен. 20, 2022
Язык: Английский
Процитировано
18