Effects of exposure to multiple metallic elements in the first trimester of pregnancy on the risk of preterm birth

Maternal and Child Nutrition, Год журнала: 2024, Номер 20(4)

Опубликована: Июнь 24, 2024

Abstract Exposure to certain heavy metals has been demonstrated be associated with a higher risk of preterm birth (PTB). However, studies focused on the effects other metal mixtures were limited. A nested case‒control study enrolling 94 PTB cases and 282 controls was conducted. Metallic elements detected in maternal plasma collected first trimester using inductively coupled plasma‒mass spectrometry. The effect exposure investigated logistic regression, least absolute shrinkage selection operator, restricted cubic spline (RCS), quantile g computation (QGC) Bayesian kernel machine regression (BKMR). Vanadium (V) arsenic (As) positively model, V remains multi‐exposure model. QGC analysis determined (69.42%) nickel (Ni) (70.30%) as maximum positive negative contributors risk, respectively. BKMR models further relationship between levels identified most important independent variable among elements. RCS showed an inverted U‐shape gestational age, more than 2.18 μg/L considered factor for shortened gestation length. metallic consisting V, As, cobalt, Ni, chromium manganese increased PTB, promoting incidence PTB.

Язык: Английский

Early pregnancy metal levels in maternal blood and pregnancy outcomes

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Ноя. 13, 2024

Prenatal exposure to heavy metals such as Lead (Pb), arsenic (As), cadmium (Cd), and selenium (Se) is associated with various adverse pregnancy outcomes. This study examines the association between early maternal blood levels of these outcomes, while also addressing differences low-risk high-risk groups based on having a history preterm birth (PTB). prospective cohort recruited parous women during first trimester, categorized into groups. Participants completed questionnaire, metal were measured in samples. Pregnancy outcomes including PTB, low weight (LBW), gestational age at delivery, head circumference recorded following delivery. Multivariable analyses conducted evaluate independent associations adjusting for age, BMI, employment, smoking, fertility treatments education. Among 404 participants, mean (± SD) Pb: 3.12 ± 1.82 µg/L, As: 0.41 0.4 Cd: 0.26 0.34 Se: 119.84 21.05 µg/L. Significant Pb, Se, Cd As observed groups, higher group. However, no significant found any either univariable comparison or multivariable models. These findings highlight need further research understand potential impact pregnancy, considering population-specific factors timing.

Язык: Английский

State-of-the-art Investigation on the Role of Indium, Terbium, Yttrium, and Lanthanum in Recurrent Pregnancy Loss

Biological Trace Element Research, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

Язык: Английский