Clinical manifestations and treatment of candidemia caused by different Candida species: a retrospective study DOI Creative Commons
Chenguang Zhang, Sheng Wu, Xuyan Chen

и другие.

BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)

Опубликована: Ноя. 4, 2024

Candidemia leads to higher mortality and longer hospital-stay. While the studies about clinical manifestations of candidemia caused by different Candida species relationship between antifungal drugs prognosis were rarely performed. This retrospective study enrolled all 94 patients diagnosed as from January 2020 July 2023 in BTCH. Demographic information, comorbidities, laboratory parameters, medications collected analyzed. C. albicans was most common specie candidemia. There no significant difference age, gender hospital-mortality groups. Higher-level duration broad-spectrum antibiotic use, lower BMI, hypoalbuminemia, PN history G+ coccemia conclusive mortality. The C.tropicalis group had SCRE levels (F = 8.40, P 0.03) shorter TTP 5.03, < 0.01) than other species. No distinction found groups including triazoles echinocandins after 7 days treatment (χ2 0.05, 0.81). efficacy (χ12 1.20, P1 0.75; χ22 P2 accounts among candida induecd candidemia.The Elder, hypoproteinemia, higher-level support increase risks for are same when blood culture turned negative days.

Язык: Английский

Nineteen years retrospective analysis of epidemiology, antifungal resistance and a nomogram model for 30-day mortality in nosocomial candidemia patients DOI Creative Commons
Dai Zhang,

Xuhong Lan,

Minjing Cai

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 15

Опубликована: Фев. 3, 2025

Background The incidence of nosocomial candidemia has increased in recently years, however, the epidemiological data remain insufficient China. Methods A total 234 patients were included from Xiamen University Zhong Shan hospital between January 2006 and October 2024. Incidence, species proportion, distribution, antifungal drug resistance was analyzed. nomogram model for 30-day morbidity determined using least absolute shrinkage logistic regression analysis. Results recent years (2020: 0.025%, 2021: 0.029%, 2023:0.022%). dominant Candida albicans (n=99,42.31%), parapsilosis (n=47,20.09%), tropicalis (n=43,18.38%), glabrata (n=31,13.25%). Departments with a higher detection intensive care unit (n=55), emergency department (n=24) hepatobiliary surgery (n=22). performed highest to azole (fluconazole: 55.81%, voriconazole:55.00% itraconazole:58.14%). fluconazole, voriconazole itraconazole 32.32%, 23.53% 31.31%. mortality rate discharge reached 52.99%. 205 cases December 2023 as training set, while 29 candidiasis 2004 validation set. Five independent factors , decreased albumin, multiple organ dysfunction syndrome, solid tumor septic shock adopted 30-days candidemia. In area under curve 0.866 (95%CI: 0.817-0.916), optimal cutoff value 0.617, sensitivity 80% specificity 80.4%. 0.808 (95%CI:0.737-0.970), 0.543. 72.7% 83.3%. Conclusion risen years. remains primary species, is unit. exhibits drugs. predicting been constructed, risk including shock, tumors, albumin.

Язык: Английский

Процитировано

3

Impact of Fluconazole Resistance on the Outcomes of Patients With Candida parapsilosis Bloodstream Infections: A Retrospective Multicenter Study DOI Creative Commons
Antonio Vena, Giusy Tiseo, Marco Falcone

и другие.

Clinical Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Abstract Background This study assesses the impact of fluconazole resistance on 30-day all-cause mortality and 1-year recurrence in patients with Candida parapsilosis bloodstream infections (BSI). Methods A multicenter retrospective was performed at 3 hospitals Italy Spain between 2018 2022. Adult positive blood cultures for C. who received appropriate targeted therapy either echinocandins or were included. Results Among 457 patients, 196 (42.9%) had fluconazole-resistant (FLZR-CP) BSI 261 (57.1%) fluconazole-susceptible (FLZS-CP) BSI. All FLZR-CP echinocandins, while FLZS-CP (60.5%) (39.5%). Unadjusted rates 28.6% 28.4% (log-rank test, P = .998). In multivariable analysis, increased associated age (adjusted hazard ratio [aHR] 1.03 per year; 95% confidence interval [CI], 1.01–1.05; .0005), solid tumor (aHR 1.91; CI, 1.06–3.46; .0302), previous antifungal treatment 1.84; 1.12–3.10; .0192), septic shock 2.39; 1.42–4.06; .0010), but not 1.00; .62–1.63; .9864) nor type initial 1.46; .69–3.06; .3202). Propensity score-matched analysis showed no difference echinocandin-treated fluconazole-treated (HR 0.81; .37–1.75; .5915). However, a higher risk observed (odds ratio, 7.37; 2.11–25.80; .0018). Conclusions Our results suggest that is BSI, though group.

Язык: Английский

Процитировано

2

Clinical manifestations and treatment of candidemia caused by different Candida species: a retrospective study DOI Creative Commons
Chenguang Zhang, Sheng Wu, Xuyan Chen

и другие.

BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)

Опубликована: Ноя. 4, 2024

Candidemia leads to higher mortality and longer hospital-stay. While the studies about clinical manifestations of candidemia caused by different Candida species relationship between antifungal drugs prognosis were rarely performed. This retrospective study enrolled all 94 patients diagnosed as from January 2020 July 2023 in BTCH. Demographic information, comorbidities, laboratory parameters, medications collected analyzed. C. albicans was most common specie candidemia. There no significant difference age, gender hospital-mortality groups. Higher-level duration broad-spectrum antibiotic use, lower BMI, hypoalbuminemia, PN history G+ coccemia conclusive mortality. The C.tropicalis group had SCRE levels (F = 8.40, P 0.03) shorter TTP 5.03, < 0.01) than other species. No distinction found groups including triazoles echinocandins after 7 days treatment (χ2 0.05, 0.81). efficacy (χ12 1.20, P1 0.75; χ22 P2 accounts among candida induecd candidemia.The Elder, hypoproteinemia, higher-level support increase risks for are same when blood culture turned negative days.

Язык: Английский

Процитировано

2