Candida Infections in COVID-19 Patients: A Review of Prevalence, Risk Factors, and Mortality

Indian Journal of Medical Microbiology, Год журнала: 2025, Номер unknown, С. 100831 - 100831

Опубликована: Март 1, 2025

Candida spp. infections have increasingly been reported among COVID-19 patients, yet the epidemiological factors, diagnostic methods, and outcomes associated with these remain poorly understood. These infections, particularly in ICU settings, present significant challenges due to high mortality rates rising antifungal resistance. This study aimed investigate occurrence, risk treatment, of albicans non-albicans providing clinical insights. A review following PRISMA guidelines was conducted. Searches were performed PubMed, Embase, BVS databases, covering articles published from January 2020 May 2024. Inclusion criteria included case reports or series detailed information on patients. Data extraction focused patient demographics, underlying diseases, antibiotic therapies, susceptibility, resistance profiles, outcomes. Statistical analyses conducted using SPSS software. The 67 studies, totaling 223 Male patients predominant. Common comorbidities hypertension, cancer, dyslipidemia. Echinocandins primary treatment. Non-albicans exhibited a higher rate (47.10 %) compared C. (2.35 %). Overall high, at 60.50 % for 62.30 non-albicans. Significant factors age, central venous catheter use, admission, corticosteroid therapy. identified critical characteristics infections. incidence highlight need vigilant monitoring targeted strategies improve

Язык: Английский

Retrospective Analysis of Fungal Isolations in Patients on Veno-Venous Extracorporeal Membrane Oxygenation: The Multicenter RANGER STUDY 2.0

Journal of Fungi, Год журнала: 2025, Номер 11(5), С. 377 - 377

Опубликована: Май 15, 2025

Background: Veno-venous extracorporeal membrane oxygenation (V-V ECMO) represents a progressively adopted life-sustaining intervention worldwide, particularly in the management of acute respiratory distress syndrome. Nevertheless, data concerning prognostic significance fungal isolation this setting remain unclear. This study aims (i) to assess incidence infection and colonization homogeneous cohort V-V ECMO patients, (ii) evaluate association between or 1-year mortality, with focus on impact specific species. Methods: All consecutive adults admitted Intensive Care Units five Italian university-affiliated hospitals requiring were screened. Exclusion criteria age < 18 years, pregnancy, veno-arterial mixed ECMO-configuration, incomplete records survival 24 h after placement. A standard protocol microbiological surveillance was applied distinction different species made through vivo vitro tests. Cox-proportional hazards models, Kaplan-Meier curves linear logistic regressions for investigating mortality. Results: Two-hundred seventy-nine patients (72% male) enrolled. The overall 41% (n. 114): 23% infections 18% colonizations. among isolations, 40%, no risk case (26 out 63, 41%) (aHR 0.85, 95% CI [0.53-1.37], p-value 0.505) (20 51, 39%) 0.86, 95%CI [0.51-1.43], 0.556), as compared never detecting fungi (68 165, 41%, reference). According isolated mycotic species, Candida sp. group (reference), death greater when (e.g., Aspergillus sp.) concomitantly same patient (OR 1.17, [1.12-11.07], 0.031. Conclusions: In population, recorded 'late' colonizations, similar experiencing during course. detection concomitant an independent factor

Язык: Английский

Diagnosis and Management of Candida Endophthalmitis and Chorioretinitis

Clinical Microbiology and Infection, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский