Bassoon, Presynaptic Scaffolding Protein: Narrative Review in Health and Disease
European Journal of Neuroscience,
Год журнала:
2025,
Номер
61(5)
Опубликована: Март 1, 2025
ABSTRACT
The
release
of
synaptic
vesicles
(SVs)
at
the
junction
is
a
complex
process
involving
various
specialized
proteins
that
work
in
unison.
Among
these,
Bassoon
has
emerged
as
significant
protein,
particularly
noted
for
its
association
with
neurological
and
aging‐related
diseases.
Due
to
structural
functional
roles,
become
focus
recent
research,
especially
understanding
implications
neurodegenerative
psychiatric
disorders.
In
this
narrative
review,
we
explore
Bassoon's
structure,
function,
role
across
spectrum
Neurotransmission
tightly
regulated
relies
on
structures
within
presynaptic
terminal,
such
active
zone
(AZ),
precisely
control
SV
response
incoming
signals.
AZ
comprises
network
large,
multidomain
proteins,
playing
crucial
arrangement.
facilitates
tethering
reloading
SVs,
ensuring
responsiveness
high‐frequency
signals,
while
also
maintaining
proteostasis
presynapse.
This
involves
orchestrating
localization
essential
neuronal
development
plasticity.
large
size
unique
features
enable
it
interact
regulate
function
multiple
making
integral
functioning.
Variants
gene
have
been
linked
variety
conditions,
including
Progressive
Supranuclear
Palsy,
system
atrophy
(MSA),
epilepsy,
schizophrenia,
bipolar
disorder,
Parkinson's
disease.
review
delves
into
pivotal
preserving
integrity
how
disruptions
functions
may
contribute
these
Язык: Английский
The Genetic Background of the Immunological and Inflammatory Aspects of Progressive Supranuclear Palsy
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 3927 - 3927
Опубликована: Апрель 22, 2025
Progressive
supranuclear
palsy
(PSP)
is
a
neurodegenerative
disease,
classified
as
an
atypical
Parkinsonian
syndrome,
that
has
been
pathologically
and
clinically
defined.
The
histopathological
aspects
of
the
disease
include
tufted
astrocytes,
while
clinical
features
involve
oculomotor
dysfunction,
postural
instability,
akinesia,
cognitive
impairment,
language
difficulties.
Although
PSP
generally
considered
sporadic
interest
growing
in
its
genetics,
with
contemporary
research
focusing
on
familial
backgrounds
neuroinflammation.
Indeed,
microglial
activation
other
inflammatory
mechanisms
pathogenesis
have
extensively
analyzed
using
genetic
examinations
to
identify
factors
impacting
neurodegeneration.
As
such,
this
review
aims
elaborate
recent
findings
field.
Язык: Английский