The Developmental Origins of Irritable Bowel Syndrome: A Systematic Review and Meta‐Analysis
American Journal of Human Biology,
Год журнала:
2025,
Номер
37(1)
Опубликована: Янв. 1, 2025
The
Developmental
Origins
of
Health
and
Disease
(DOHaD)
framework
contends
that
chronic
diseases
are
attributable
to
behavioral
environmental
risks
encountered
during
vital
periods
fetal
childhood
development.
Clinical
research
investigating
irritable
bowel
syndrome
(IBS)
largely
focuses
on
adult
risk
factors,
with
emerging
evidence
epigenetic
contributions.
Limited
work
considers
potential
exposures.
This
paper
applies
a
life
course
approach
the
study
IBS,
exploring
available
ascertain
developmental
origins
IBS.
Язык: Английский
Caring for Children with Disorders of Gut-Brain Interaction in Resource-Limited Settings
Gastroenterology Clinics of North America,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Gastrointestinal Cognition: Pain Catastrophizing in Irritable Bowel Syndrome, a Cross‐Sectional Study in Mexico
Neurogastroenterology & Motility,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
ABSTRACT
Introduction
and
Aims
Pain
catastrophizing
is
more
common
in
individuals
with
irritable
bowel
syndrome
(IBS)
than
healthy
individuals.
Despite
this,
its
prevalence
impact
Latin
American
populations
remain
under‐researched.
Objective
To
assess
pain
differences
between
IBS
patients
subjects.
Materials
Methods
Cross‐sectional
study
which
subjects
(HC)
were
recruited
from
our
tertiary
care
center.
diagnosis
was
established
based
on
the
Rome
IV
criteria.
All
participants
answered
scale
(PCS),
hospital
anxiety
depression
(HAD),
severity
scoring
system
(IBS‐SSS).
Group
comparisons
employed
Student's
t
‐test
or
Mann–Whitney
U
test,
Pearson's
Spearman's
for
correlations
logistic
regression
to
predictors.
Results
A
total
of
920
(66.4%
women)
a
median
age
23
years
(range:
18–60)
met
inclusion
had
higher
clinically
significant
compared
(22.5%
vs.
11%,
p
<
0.0001).
When
classified
by
symptom
intensity,
52.2%
severe
symptoms
exhibited
catastrophizing,
25.3%
moderate
14.7%
mild
(
Anxiety
(OR
2.5,
95%
CI
1.9–3.4,
0.0001),
1.7,
1.3–2.3,
2.3,
1.6–3.3,
0.0001)
significantly
associated
IBS.
Conclusions
In
Mexican
IBS,
gastrointestinal
psychological
distress.
Comprehensive
management
this
population
should
involve
addressing
cognitive
patterns
conjunction
conventional
treatments.
Язык: Английский
The Mediating Effects of Chronic Diseases in the Relationship Between Adverse Childhood Experiences and Trajectories of Depressive Symptoms in Later Life: A Nationwide Longitudinal Study
Healthcare,
Год журнала:
2024,
Номер
12(24), С. 2539 - 2539
Опубликована: Дек. 16, 2024
Background:
Numerous
studies
have
established
a
link
between
adverse
childhood
experiences
(ACEs)
and
the
development
of
depression
in
later
life.
However,
interactive
relationships
ACEs,
depression,
chronic
diseases
are
still
not
well
understood.
In
this
study,
aim
was
to
investigate
impact
ACEs
on
depressive
trajectories
among
middle-aged
elderly
individuals
China,
as
examine
mediating
roles
association.
Methods:
Data
were
drawn
from
6921
participants
aged
45
older,
using
China
Health
Retirement
Longitudinal
Study
(CHARLS)
data
2011,
2013,
2015,
2018,
combined
with
2014
life
history
survey.
Depressive
symptom
scores
assessed
widely
recognized
CES-D-10
scale.
The
symptoms
identified
via
group-based
trajectory
modeling
(GBTM).
association
analyzed
multinomial
logistic
regression,
KHB
method
employed
test
effects
different
diseases.
Results:
age
57.2
±
8.0
years,
females
comprising
53.9%
males
46.1%.
We
found
that
approximately
70%
Chinese
older
adults
had
experienced
at
least
one
ACE,
4.8%
four
or
more
ACEs.
following
distinct
identified:
continuing-low
(N
=
1897,
27.4%),
continuing-low-to-middle
2937,
42.4%),
continuing-middle-to-high
1649,
23.8%),
continuing-high
438,
6.3%).
Compared
without
those
significantly
higher
likelihood
(OR
2.407,
95%CI:
1.633–3.550),
7.458,
4.999–11.127),
20.219,
12.115–33.744),
rather
than
trajectory.
Exposure
greater
number
associated
an
increased
risk
symptoms.
Multiple
mediated
relationship
trajectories,
arthritis
rheumatism
exerting
largest
effect,
followed
by
digestive
respiratory
Conclusions:
These
findings
indicated
worse
relationship.
Therefore,
developing
public
measures
prevent
can
reduce
people.
Additionally,
strengthening
prevention
management
exposed
may
further
their
subsequent
depression.
Язык: Английский
Association Between Irritable Bowel Syndrome and Lower Urinary Tract Symptomatology
Journal of Clinical Gastroenterology,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 24, 2024
Goals:
This
study
aimed
to
investigate
the
clinical
phenotype
of
urinary
symptoms
in
patients
diagnosed
with
irritable
bowel
syndrome,
factors
associated
this
overlap,
and
impact
on
their
quality
life.
Background:
Irritable
syndrome
is
a
common
disorder,
affecting
up
3.8%
population.
The
overlap
other
disorders
gut-brain
interaction,
psychiatric
disorders,
somatic
common.
Moreover,
association
between
has
been
recognized,
but
remains
unclear.
Study:
cross-sectional
involved
according
Rome
IV.
Lower
tract
were
classified
using
International
Continence
Society’s
classification.
Data
demographics,
medical
history,
medication
use,
anxiety,
depression,
life
collected
analyzed
logistic
regression
analysis.
Results:
included
428
subjects,
86
syndrome.
Patients
exhibited
higher
prevalence
lower
(60.5%,
95%
CI:
50.5-71.9).
Multivariate
analysis
revealed
associations
(OR:
2.49,
1.48-4.18,
P
=0.001),
particularly
storage
1.94,
1.10-3.40,
=0.021).
reported
significantly
compared
those
without
these
(50.8±17.2
vs.
76.7±21.8,
<0.001).
Conclusions:
symptoms,
contributing
significant
reduction
Clinicians
should
consider
referring
experts
urodynamics
provide
targeted
management.
Язык: Английский
Bidirectional relationship between gastrointestinal cancer and depression: The key is in the microbiota-gut-brain axis
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
30(48), С. 5104 - 5110
Опубликована: Ноя. 29, 2024
In
this
Editorial,
we
review
the
recent
publication
in
World
Journal
of
Gastroenterology
,
which
explores
complex
relationship
between
depression
and
gastric
cancer
offers
perspectives.
Key
topics
discussed
include
microbiota-gut-brain
axis,
dysbiosis,
influence
microbial
metabolites
homeostasis.
Additionally,
address
toxic
stress
caused
by
hypothalamic-pituitary-adrenal
axis
dysregulation,
psychological
assessments,
future
research
directions.
Our
Editorial
aims
to
expand
understanding
bidirectional
gastrointestinal
cancer.
Язык: Английский
Prevalence of Eating Disorders Among Adults With Irritable Bowel Syndrome
Journal of Clinical Gastroenterology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 12, 2024
Goal:
To
investigate
the
prevalence
of
eating
disorder
(ED)
symptoms
among
Mexican
adults
with
irritable
bowel
syndrome
(IBS).
Background:
The
relationship
between
IBS
and
EDs
is
complex,
yet
understudied,
particularly
in
Latin
America.
Methods:
In
this
cross-sectional
study,
369
(18
to
69
y),
comprising
133
patients
236
healthy
controls
(HCs),
were
evaluated
using
Rome
IV
criteria,
Spanish
version
Eating
Disorder
Examination
Questionnaire
(S-EDE-Q),
Irritable
Bowel
Syndrome
Symptom
Severity
Scale
(IBS-SSS)
Hospital
Anxiety
Depression
(HADS).
Statistical
analysis
included
Student
t
test
or
Wilcoxon
Rank-sum
for
group
comparisons,
Kruskal-Wallis
multiple
logistic
regression,
a
significance
threshold
set
at
P
-value
<0.05.
Results:
individuals
an
increased
risk
clinically
significant
S-EDE-Q
when
compared
HCs
(12.8%
vs.
3.8%,
odds
ratio
OR
3.6,
95%
CI:
1.5-8.5;
=0.001),
especially
younger
individuals.
displayed
higher
dietary
restraint
heightened
concerns
about
eating,
body
shape,
weight.
addition,
binge-eating
episodes
occurred
more
frequently
within
group.
Notably,
there
no
differences
mass
index
those
normal
scores.
severe
had
scores;
furthermore,
exhibited
levels
anxiety
depression.
Conclusions:
Our
study
reveals
significantly
ED
HCs.
This
highlights
crucial
importance
conducting
screenings
before
interventions,
displaying
elevated
Язык: Английский