Новые Санкт-Петербургские врачебные ведомости.,
Год журнала:
2024,
Номер
2, С. 25 - 33
Опубликована: Ноя. 1, 2024
In
recent
years,
increasing
attention
of
researchers
has
been
paid
to
the
role
melatonin
in
regulation
body
weight.
When
analyzing
literature
data,
problem
mechanism
action
on
and
its
use
correction
metabolic
disorders
is
considered.
Disruption
circadian
rhythms
caused
by
artificial
light
at
night
leads
decreased
secretion.
This
helps
increase
appetite
reduce
energy
costs.
addition,
plays
a
major
modulating
secretion
adipokines
influencing
lipid
metabolism.
Decreased
production
causes
insulin
resistance
disorganization,
leading
obesity.
Assessing
development
obesity
accompanying
pathologies
promising
area
scientific
research
field
diagnosis,
prevention
treatment
endocrine
cardiovascular
pathologies.
International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
23(1), С. 218 - 218
Опубликована: Дек. 25, 2021
Obesity
and
its
complications
have
become
a
prominent
global
public
health
problem
that
severely
threatens
human
health.
Melatonin,
originally
known
as
an
effective
antioxidant,
is
endogenous
hormone
found
throughout
the
body
serves
various
physiological
functions.
In
recent
decades,
increasing
attention
has
been
paid
to
unique
function
in
regulating
energy
metabolism,
especially
glucose
lipid
metabolism.
Accumulating
evidence
established
relationship
between
melatonin
obesity;
nevertheless,
not
all
preclinical
clinical
indicates
anti-obesity
effect
of
melatonin,
which
makes
it
remain
conclude
fight
against
obesity.
this
review,
we
summarized
current
knowledge
obesity-related
symptoms,
with
emphasis
on
underlying
mechanisms.
The
role
profile,
adipose
tissue,
oxidative
stress,
inflammation,
well
interactions
circadian
rhythm,
gut
microbiota,
sleep
disorder,
α7nAChR,
opioidergic
system,
exosomes,
make
promising
agent
open
new
avenues
intervention
Biomedicine & Pharmacotherapy,
Год журнала:
2022,
Номер
156, С. 113903 - 113903
Опубликована: Окт. 22, 2022
Doxorubicin
(DOX),
as
a
kind
of
chemotherapy
agent
with
remarkable
therapeutic
effect,
can
be
used
to
treat
diverse
malignant
tumors
clinically.
Dose-dependent
cardiotoxicity
is
the
most
serious
adverse
reaction
after
DOX
treatment,
which
eventually
leads
cardiomyopathy
and
greatly
limits
clinical
application
DOX.
DOX-induced
not
result
single
mechanistic
action,
multiple
mechanisms
have
been
discovered
demonstrated
experimentally,
such
oxidative
stress,
inflammation,
mitochondrial
damage,
calcium
homeostasis
disorder,
ferroptosis,
autophagy
apoptosis.
Dexrazoxane
(DEX)
only
protective
approved
by
FDA
for
treatment
cardiomyopathy,
but
its
still
has
some
limitations.
Therefore,
we
need
find
other
effective
drugs
soon
possible.
In
this
paper,
that
effectively
improve
in
recent
years
are
mainly
described
from
aspects
natural
drugs,
endogenous
substances,
new
dosage
forms,
herbal
medicines,
chemical
modification
marketed
drugs.
The
aim
present
study
evaluate
effects
these
on
anticancer
curative
effects,
so
provide
reference
value
future.
Melatonin
appears
to
be
a
promising
supplement
for
obesity
treatment.
The
antiobesity
effects
of
melatonin
on
obese
rodents
are
influenced
by
various
factors,
including
the
species,
sex,
dosage
melatonin,
treatment
duration,
administration
via,
daily
time,
and
initial
body
weight
(IBW).
Therefore,
we
conducted
meta-analysis
machine
learning
study
evaluate
effect
mice
or
rats
from
31
publications.
results
showed
that
significantly
reduced
weight,
serum
glucose
(GLU),
triglycerides
(TGs),
low-density
lipoprotein
(LDL),
cholesterol
(TC)
levels
in
but
increased
high-density
(HDL)
levels.
slight
positive
clock-related
genes,
although
number
studies
was
limited.
Meta-regression
analysis
indicated
primary
factor
influencing
with
higher
dosages
leading
stronger
reduction
effect.
Together,
male
C57BL/6
Sprague-Dawley
an
IBW
100-200
g
better
when
supplemented
dose
10-30
mg/kg
administered
at
night
via
injection
5-8
weeks.
Nutrients,
Год журнала:
2024,
Номер
16(7), С. 1011 - 1011
Опубликована: Март 30, 2024
Melatonin
(N-acetyl-5
methoxytryptamine)
is
an
indolic
neurohormone
that
modulates
a
variety
of
physiological
functions
due
to
its
antioxidant,
anti-inflammatory,
and
immunoregulatory
properties.
Therefore,
the
purpose
this
study
was
critically
review
effects
melatonin
supplementation
in
sports
performance
circulating
biomarkers
related
health
status
highly
trained
athletes.
Data
were
obtained
by
performing
searches
following
three
bibliography
databases:
Web
Science,
PubMed,
Scopus.
The
terms
used
“Highly
Trained
Athletes”,
“Melatonin”,
“Sports
Performance”,
“Health
Biomarkers”
using
“Humans”
as
filter.
search
update
carried
out
February
2024
from
original
articles
published
with
controlled
trial
design.
PRISMA
rules,
modified
McMaster
critical
form
for
quantitative
studies,
PEDro
scale,
Cochrane
risk
bias
applied.
According
inclusion
exclusion
criteria,
21
selected
294
references.
dose
supplemented
trials
ranged
between
5
mg
100
administered
before
or
after
exercise.
outcomes
showed
improvements
antioxidant
inflammatory
response
reversed
liver
damage
muscle
damage.
Moderate
on
modulating
glycemia,
total
cholesterol,
triglycerides,
creatinine
reported.
Promising
data
found
regarding
potential
benefits
hematological
biomarkers,
hormonal
responses,
performance.
true
efficiency
directly
improve
remains
be
assessed.
Nevertheless,
indirect
effect
could
evaluated
through
biomarkers.
Nutrients,
Год журнала:
2024,
Номер
16(10), С. 1422 - 1422
Опубликована: Май 8, 2024
Breastfeeding
is
the
most
appropriate
source
of
a
newborn’s
nutrition;
among
plethora
its
benefits,
modulation
circadian
rhythmicity
with
melatonin
as
potential
neuroendocrine
transducer
has
gained
increasing
interest.
Transplacental
transfer
assures
provision
for
fetus,
who
devoid
secretion.
Even
after
birth,
neonatal
pineal
gland
not
able
to
produce
rhythmically
several
months
(with
an
even
more
prolonged
deficiency
following
preterm
birth).
In
this
context,
human
breast
milk
constitutes
main
natural
melatonin:
diurnal
dynamic
changes,
acrophase
early
midnight,
and
changes
in
concentrations
according
gestational
age
during
different
stages
lactation
have
been
reported.
Understudied
thus
far
are
factors
impacting
on
(changes
in)
content
their
clinical
significance
chronobiological
adherence
neonate:
maternal
well
environmental
aspects
be
investigated
detail
guide
nursing
mothers
optimal
feeding
schedules
which
probably
means
synchronized
instead
mistimed
practice.
This
review
aims
thought-provoking
regarding
critical
role
chrononutrition
breastfeeding,
highlighting
entrainment
therefore
optimizing
(neuro)developmental
outcomes
setting.
Food and Agricultural Immunology,
Год журнала:
2024,
Номер
35(1)
Опубликована: Авг. 2, 2024
Since
the
1990s
worldwide
rate
of
obesity
has
escalated
significantly.
This
overflow
affects
all
demographic
groups,
with
a
notable
impact
on
older
adults
and
women.
Obesity
is
associated
variety
serious
chronic
health
conditions.
Additionally,
it
linked
to
endocrine
disorders
such
as
hypothyroidism
subclinical
hypothyroidism.
review
analyzes
connection
between
micronutrient
levels,
particularly
focusing
vitamin
D,
evaluates
potential
nutritional
supplementation
approaches
for
this
population.
Antioxidants,
Год журнала:
2023,
Номер
12(10), С. 1844 - 1844
Опубликована: Окт. 10, 2023
The
aim
of
this
review
is
to
explore
the
relationship
between
melatonin,
free
radicals,
and
non-excitatory
amino
acids,
their
role
in
stroke
aging.
Melatonin
has
garnered
significant
attention
recent
years
due
its
diverse
physiological
functions
potential
therapeutic
benefits
by
reducing
oxidative
stress,
inflammation,
apoptosis.
been
found
mitigate
ischemic
brain
damage
caused
stroke.
By
scavenging
radicals
damage,
melatonin
may
help
slow
down
aging
process
protect
against
age-related
cognitive
decline.
Additionally,
acids
have
shown
possess
neuroprotective
properties,
including
antioxidant
anti-inflammatory
aging-related
conditions.
They
can
attenuate
modulate
calcium
homeostasis,
inhibit
apoptosis,
thereby
safeguarding
neurons
induced
processes.
intracellular
accumulation
certain
could
promote
harmful
effects
during
hypoxia-ischemia
episodes
thus,
blockade
acid
transporters
involved
be
an
alternative
strategy
reduce
damage.
On
other
hand,
specifically
mitochondrial
reactive
oxygen
nitrogen
species,
accelerates
cellular
senescence
contributes
Recent
research
suggests
a
complex
interplay
actions
converge
on
multiple
pathways,
regulation
modulation
reduction
inflammation.
These
mechanisms
collectively
contribute
preservation
neuronal
integrity
functions,
making
them
promising
targets
for
interventions
disorders.
Obesity
is
a
chronic
condition
whose
management
critical
challenge
for
physicians.
The
scientific
community
has
increased
its
focus
on
the
molecular
mechanisms
involved
in
obesity
etiopathogenesis
to
better
manage
patients
with
and
associated
complications.
tight
connection
between
adipose
tissue
immune
system
been
demonstrated
play
crucial
role
inflammation,
melatonin
important
circadian
rhythm
regulation
metabolic
homeostasis,
which
it
orchestrates
several
inflammation.
Melatonin
also
regulates
innate
adaptive
immunity;
antioxidant
properties
are
linked
reduced
predisposition
infection
weight
gain
through
modulation
of
response,
significant
beneficial
effect
inflammation
and,
consequently,
state.
Low
levels
have
obesity,
supplementation
can
reduce
body
weight,
improve
profile,
ameliorate
responses
pro-inflammatory
stimuli.
mainly
related
improved
oxidative
stress
signaling,
adipokine
secretion,
switching
from
white-to-brown
phenotype
activity.
Moreover,
by
controlling
recently
emerged
as
pivotal
mechanism
lipid
glucose
metabolism
dysfunction
adipose,
muscle,
liver
tissues.
may
regulate
acting
directly
thymus
morphology
activity
well
modulating
inflammatory
states
during
infections.
association
response
coordinated
Toll-like
receptors,
rhythmically
expressed
day.
Their
expression
be
strongly
modulated
their
signaling
highly
inhibited
melatonin.
current
review
summarizes
studies
melatonin-induced
regulation,
particularly
obesity-associated
systemic
Nutrients,
Год журнала:
2025,
Номер
17(5), С. 784 - 784
Опубликована: Фев. 24, 2025
Background/Objectives:
Obesity
is
linked
to
a
higher
risk
of
cognitive
impairment.
The
objective
this
single
blind
randomized
trial
was
evaluate
the
impact
dark
sweet
cherry
(DSC)
intake
on
function
in
obese
adults.
Methods:
Participants
(body
mass
index
(BMI):
30-40
kg/m2,
>18
years,
without
chronic
diseases
and/or
antibiotic
use)
consumed
200
mL
DSC
drink
with
3
g
powder
(n
=
19)
or
an
isocaloric
placebo
21)
twice
daily
for
30
days.
Cognitive
assessed
at
Day
1
(D1)
and
(D30)
using
standardized
tests
NeuroTracker
(NT)
3D
training
program.
Blood
biomarkers
related
health
(neurotensin,
substance
p,
oxytocin)
circadian
rhythm
(melatonin
cortisol)
were
D1
D30
Luminex
multiplex
bead-based
immunoassay.
Results:
supplementation
significantly
improved
working
memory
concentration,
as
indicated
by
scores
digit
span
forward
(DSF,
p
0.006)
backward
(DSB,
0.01)
tests.
However,
processing
speed,
sustained
attention,
visual
spatial
skills,
through
trail
making
(TMT)
symbol
substitution
(DSST)
tests,
well
performance
(VCP)
evaluated
NT
program,
showed
no
significant
differences
between
groups.
Neurotensin,
associated
deficits,
increased
both
groups
but
only
group
(p
0.007).
Similarly,
melatonin
groups,
reaching
significance
0.02),
it
correlated
positively
IFNγ,
suggesting
compensatory
response
inflammation.
Conclusions:
These
findings
suggest
may
enhance
specific
functions
Further
clinical
trials
are
needed
confirm
these
results.
