Новые Санкт-Петербургские врачебные ведомости.,
Год журнала:
2024,
Номер
2, С. 25 - 33
Опубликована: Ноя. 1, 2024
In
recent
years,
increasing
attention
of
researchers
has
been
paid
to
the
role
melatonin
in
regulation
body
weight.
When
analyzing
literature
data,
problem
mechanism
action
on
and
its
use
correction
metabolic
disorders
is
considered.
Disruption
circadian
rhythms
caused
by
artificial
light
at
night
leads
decreased
secretion.
This
helps
increase
appetite
reduce
energy
costs.
addition,
plays
a
major
modulating
secretion
adipokines
influencing
lipid
metabolism.
Decreased
production
causes
insulin
resistance
disorganization,
leading
obesity.
Assessing
development
obesity
accompanying
pathologies
promising
area
scientific
research
field
diagnosis,
prevention
treatment
endocrine
cardiovascular
pathologies.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Май 9, 2023
Abstract
Statistical
epistasis
has
been
studied
extensively
because
of
its
potential
to
provide
evidence
for
genetic
interactions
phenotypes,
but
there
have
methodological
limitations
exhaustive,
widespread
application.
We
present
new
algorithms
the
interaction
coefficients
standard
regression
models
that
permit
many
varied
encodings
terms
loci
and
efficient
memory
usage.
The
are
given
two-way
three-way
may
be
generalized
higher
order
epistasis.
tests
also
provided.
an
matrix
based
algorithm
permutation
testing
offer
a
proof
experimental
methods
look
only
at
main
effects
not
justified.
Given
computational
efficiency
algorithm,
we
applied
method
rat
data
set
mouse
set,
with
least
10000
1000
samples
each,
using
Cartesian
encoding
XOR
penetrance
function
interactions,
test
statistical
phenotype
body
mass
index.
This
study
revealed
found
greater
in
more
pairs
both
sets
those
enriched
biologically
relevant
pathways.
Author
summary
Epistasis,
between
two
or
genes,
is
likely
integral
genetics
throughout
nature.
Yet,
it
seldom
fully
explored
as
most
approaches
primarily
focus
on
single-locus
(such
GWAS),
partly
analyzing
all
pairwise
higher-order
requires
significant
resources.
Many
current
detection
consider
terms.
limiting
epistatic
can
evolve
produce
relationships
some
non-linear.
In
this
work
describe
computationally
allow
modeling
Our
methodology
efficiently
detects
closely
related
species
(rat
mouse)
under
encodings.
results
show
would
undetected
if
one
was
providing
need
occurs
living
systems.
Clinical & experimental pathology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Май 9, 2024
The
purpose
of
the
work
–
to
analyze
current
state
study
melatonin-
dependentdisorders
energy
metabolism.Conclusions.
According
data
scientific
literary
sources
in
obesity
andmetabolic
syndrome
level
decrease
and
rhythm
disturbance
melatonin
productionare
registered.
Melatonin
is
an
effective
means
correcting
a
number
pathologicalchanges
that
accompany
development
metabolism
derangement.
Новые Санкт-Петербургские врачебные ведомости.,
Год журнала:
2024,
Номер
2, С. 25 - 33
Опубликована: Ноя. 1, 2024
In
recent
years,
increasing
attention
of
researchers
has
been
paid
to
the
role
melatonin
in
regulation
body
weight.
When
analyzing
literature
data,
problem
mechanism
action
on
and
its
use
correction
metabolic
disorders
is
considered.
Disruption
circadian
rhythms
caused
by
artificial
light
at
night
leads
decreased
secretion.
This
helps
increase
appetite
reduce
energy
costs.
addition,
plays
a
major
modulating
secretion
adipokines
influencing
lipid
metabolism.
Decreased
production
causes
insulin
resistance
disorganization,
leading
obesity.
Assessing
development
obesity
accompanying
pathologies
promising
area
scientific
research
field
diagnosis,
prevention
treatment
endocrine
cardiovascular
pathologies.
