Visceral and subcutaneous adipose stem cells modulate colorectal cancer cell progression: direct and in-direct contact distinctly accelerate tumor aggressiveness.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Май 9, 2025
Abstract
Adipose
tissue-resident
stem
cells
(ASCs),
by
interacting
with
CRC
cells,
either
directly
or
indirectly,
can
influence
various
processes
that
contribute
to
tumorigenesis.
However,
their
precise
role
in
the
development
of
invasive
cancer
remains
incompletely
characterized.
In
this
work,
a
models
both
direct
and
in-direct
co-culture
were
employed
investigate
interactions
between
ASCs.
Additionally,
we
used
ASCs
derived
from
visceral
(V-ASCs)
subcutaneous
(S-ASCs)
fat
deposits.
Application
experimental
setting
allowed
us
detect
meaning
cell-cell
contact
cross-talk
describe
how
different
depots
behavior
cells.
Our
results
demonstrated
cultivated
acquired
more
aggressive
phenotype
exhibited
features
epithelial-to-mesenchymal
transition
(EMT)
plasticity.
Moreover,
our
findings
indicate
S-ASCs
V-ASCs
induce
distinct
changes
cell
behavior,
resulting
depot-specific
actions
respective
ASC
populations.
Furthermore,
3D
spheroid
experiments
showed
greater
tumor-forming
ability
potential
when
present
under
conditions.
These
highlight
significance
adipose-derived
spreading
underscore
contribution
tumor
progression.
Язык: Английский
Mechanisms underlying obesity-malignancy connection: a systematic narrative review
Journal of Physiology and Biochemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 23, 2025
Язык: Английский