Mechanisms underlying obesity-malignancy connection: a systematic narrative review DOI
Ayesha Sultana, Sobia Rana

Journal of Physiology and Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Язык: Английский

Visceral and subcutaneous adipose stem cells modulate colorectal cancer cell progression: direct and in-direct contact distinctly accelerate tumor aggressiveness. DOI
Katarzyna Pietraszek‐Gremplewicz, Mikołaj Domagalski, Dorota Nowak

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

Abstract Adipose tissue-resident stem cells (ASCs), by interacting with CRC cells, either directly or indirectly, can influence various processes that contribute to tumorigenesis. However, their precise role in the development of invasive cancer remains incompletely characterized. In this work, a models both direct and in-direct co-culture were employed investigate interactions between ASCs. Additionally, we used ASCs derived from visceral (V-ASCs) subcutaneous (S-ASCs) fat deposits. Application experimental setting allowed us detect meaning cell-cell contact cross-talk describe how different depots behavior cells. Our results demonstrated cultivated acquired more aggressive phenotype exhibited features epithelial-to-mesenchymal transition (EMT) plasticity. Moreover, our findings indicate S-ASCs V-ASCs induce distinct changes cell behavior, resulting depot-specific actions respective ASC populations. Furthermore, 3D spheroid experiments showed greater tumor-forming ability potential when present under conditions. These highlight significance adipose-derived spreading underscore contribution tumor progression.

Язык: Английский

Процитировано

0

Mechanisms underlying obesity-malignancy connection: a systematic narrative review DOI
Ayesha Sultana, Sobia Rana

Journal of Physiology and Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Язык: Английский

Процитировано

0