Topical clobetasol treatment for oral lichen planus can cause adrenal insufficiency

Oral Diseases, Год журнала: 2023, Номер 30(3), С. 1304 - 1312

Опубликована: Апрель 27, 2023

Abstract Objective Glucocorticoids suppress the hypothalamic–pituitary–adrenal axis, which may lead to glucocorticoid‐induced adrenal insufficiency. The study aimed investigate prevalence of this state in patients with oral lichen planus treated topical clobetasol propionate. Methods In cross‐sectional study, 30 receiving long‐term (>6 weeks) propionate gel 0.025% were invited participate. Adrenal function was assessed by measuring morning plasma cortisol after a 48‐h withdrawal treatment. <280 nmol/L, cosyntropin stimulation test performed. Results Twenty‐seven included. Twenty‐one (78%) presented ≥280 nmol/L (range 280–570 nmol/L), and six (22%) 13–260 nmol/L). Five these underwent that revealed severe insufficiency two (cortisol peak 150 210 nmol/L) mild three 350–388 Conclusion approximately 20% intermittent glucocorticoid treatment for had It is essential clinicians be aware risk inform about potential need stress doses during intercurrent illness.

Язык: Английский

---

Clinical characteristics, management, and malignancy rate of oral lichen planus: a European multicenter study

Journal of Stomatology Oral and Maxillofacial Surgery, Год журнала: 2025, Номер unknown, С. 102218 - 102218

Опубликована: Янв. 1, 2025

Язык: Английский

---

Clinical Features of Oral Lichen Planus: A Pictorial and Systematic Review

Indian Journal of Otolaryngology and Head & Neck Surgery, Год журнала: 2025, Номер 77(3), С. 1692 - 1697

Опубликована: Янв. 18, 2025

Язык: Английский

---

Impact of oral precancerous lesions on oral cancer development in patients with oral lichen planus: a retrospective cohort study of 318 oral lichen planus patients

Frontiers in Oral Health, Год журнала: 2025, Номер 6

Опубликована: Март 6, 2025

Oral lichen planus (OLP) has been implicated as a potential risk factor for oral cancer. This study aimed to investigate the long-term determinants of cancer development following diagnosis OLP. A retrospective cohort 318 patients with histopathologically confirmed OLP was conducted at tertiary medical center from 1995 2018. Patients were categorized into two groups based on presence or absence precancerous lesions (OPLs). Baseline characteristics, underlying conditions, and lifestyle factors compared between groups. The hazard ratio (HR) 10-year cumulative estimated using logistic regression Kaplan-Meier analysis, respectively. In our cohort, total 33 (10.38%) diagnosed After adjusting confounders, OPLs (HR, 2.98), age over 50 years 4.36), chronic kidney disease 4.46), alcohol consumption 4.23) emerged independent in (P < 0.05). current indicates that OPLs, including histologically verrucous hyperplasia varying degrees dysplasia, is associated an increased Further research needed elucidate molecular mechanisms linking OLP, OPL, occurrence.

Язык: Английский

---

Experimental and clinical trial investigations of phyto-extracts, phyto-chemicals and phyto-formulations against oral lichen planus: A systematic review

Journal of Ethnopharmacology, Год журнала: 2022, Номер 298, С. 115591 - 115591

Опубликована: Авг. 10, 2022

Язык: Английский

---