Efficacy of comprehensive dental treatment for lichenoid reactions of the mucoparodontal complex: A single-center pilot cohort study DOI Creative Commons
О. С. Гилева, Т. В. Либик, Г. И. Рогожников

и другие.

Kuban Scientific Medical Bulletin, Год журнала: 2023, Номер 30(6), С. 102 - 111

Опубликована: Дек. 22, 2023

Background . Lichenoid reactions of the oral mucosa are currently recognized as a serious issue for dentists various specialties, since their knowledge and competence in diagnosis pathogenetic treatment lichenoid lesions cavity yet to be improved. Following data on high oncogenic potential some forms mucous membranes, should given considerations, keep oncology-related suspicion when receiving these patients. Objective To evaluate efficacy comprehensive dental mucoparodontal complex. Methods A single-center pilot cohort study was conducted (combination pharmacotherapy physiotherapy) patients with mucosa. The observation group consisted 49 (15 males, 34 females) aged 58.92 ± 0.82 years verified diagnoses reactions. suggested included (highly-potent topical steroids, calcineurin inhibitors) physiotherapy form low level laser therapy (635 nm, 10 W) provided via Matrix (Matrix, Russia). Treatment assessed by total scale efficacy, registering indicators area focal severity pain syndrome, well changes quality life according OHIP-49-RU (Oral Health Impact Profile) Russian version. Statistical processing involved Student’s t-test Wilcoxon t-test. Differences were considered significant at p ≤ 0.05. Data statistical analysis performed using SPSS 13.0 (SPSS Inc., USA). Results During follow-up period, decreased significantly (p < 0.001) 100% amounted (as medians quartiles): 6.0 (4.0–7.0) points before 1.0 (1.0–2.0) after objectified reduction (by 63.2%, syndrome (spontaneous from 2.0 (1.5–3.0) 0.0 (0.0–1.0) treatment; induced 3.0 (2.0–3.0) points). Along clinical improvement, scores improved 83.11 2.58 39.94 0.86 points, OHIP-49 RU Profile). Conclusion Early detection differentiation membranes ensure timely developed protocol physiotherapy). confirmed clinically justified relation life.

Язык: Английский

An Evidence-Based Update on the Potential for Malignancy of Oral Lichen Planus and Related Conditions: A Systematic Review and Meta-Analysis DOI Open Access
Miguel Ángel González‐Moles, Pablo Ramos‐García

Cancers, Год журнала: 2024, Номер 16(3), С. 608 - 608

Опубликована: Янв. 31, 2024

A systematic review and a meta-analysis is presented on published articles the malignant transformation of oral lichen planus (OLP) related conditions, which, based current evidence, updates an earlier by our research group that included publications until November 2018. In this updated study (Nov-2023) we searched MEDLINE, Embase, Web Science, Scopus. We evaluated methodological quality studies (QUIPS tool) carried out meta-analyses. The inclusion criteria were met 101 (38,083 patients), 20 new primary-level (11,512 patients) in last 5 years added to study. pooled ratio was 1.43% (95% CI = 1.09-1.80) for OLP; 1.38% 0.16-3.38) lichenoid lesions; 1.20% 0.00-4.25) reactions; 5.13% 1.90-9.43) OLP with dysplasia. No significant differences found between OLL or LR groups subgroup (

Язык: Английский

Процитировано

19
Oral Lichen Planus: An Update on Diagnosis and Management DOI
A. Louisy,

Eiryann Humbert,

M. Samimi

и другие.

American Journal of Clinical Dermatology, Год журнала: 2023, Номер 25(1), С. 35 - 53

Опубликована: Сен. 15, 2023

Язык: Английский

Процитировано

41
Early Diagnosis of Oral Cancer: A Complex Polyhedral Problem with a Difficult Solution DOI Open Access

Isabel González‐Ruiz,

Pablo Ramos‐García,

Isabel Ruiz‐Ávila

и другие.

Cancers, Год журнала: 2023, Номер 15(13), С. 3270 - 3270

Опубликована: Июнь 21, 2023

Oral and oropharyngeal cancers are a growing problem, accounting for 377,713 98,412 new cases per year all over the world 177,757 48,143 deaths annually, respectively. Despite substantial improvement in diagnostic procedures treatment techniques recent years, mortality rate has not decreased substantially last 40 which is still close to 50% of cases. The major cause responsible this high associated with percentage oral diagnosed advanced stages (stages III IV) where harbors poor efficacy, resulting challenges, mutilations, or disability. main reason cancer be at an stage delay, so it critical reduce delay order improve prognosis patients suffering from cancer. causes complex concern patients, healthcare professionals, services. In manuscript, critically reviewed based on current evidence, as well their causes, problems, potential strategies.

Язык: Английский

Процитировано

26
Oral lichen planus and lichenoid lesions - challenges and pitfalls for the general dental practitioner DOI Creative Commons

Rebecca S. L. Binnie,

Marianne Dobson,

Anna Chrystal

и другие.

BDJ, Год журнала: 2024, Номер 236(4), С. 285 - 292

Опубликована: Фев. 23, 2024

Abstract Lichen planus is a chronic, mucocutaneous inflammatory condition which, due to its prevalence, will be familiar the dental profession. However, diverse forms of presentation, important differential diagnosis, potential malignant change and monitoring requirements often result in challenges for those primary care. This paper looks examine these provide information support who are involved recognition management patients with lichen planus.

Язык: Английский

Процитировано

9
UK & Ireland Oral Medicine and OMFS Multidisciplinary Clinics for the Management of Oral Epithelial Dysplasia DOI Creative Commons

Liana Haywood,

Melanie Louise Simms, Philip A. Atkin

и другие.

British Journal of Oral and Maxillofacial Surgery, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Hypertension in oral lichen planus: A systematic review and meta‐analysis DOI Creative Commons

Teresa De Porras‐Carrique,

Pablo Ramos‐García, Miguel Ángel González‐Moles

и другие.

Oral Diseases, Год журнала: 2023, Номер 30(4), С. 1793 - 1805

Опубликована: Сен. 19, 2023

Abstract Objectives To perform a systematic review and meta‐analysis in order to qualitatively quantitatively evaluate the prevalence magnitude of association hypertension patients with oral lichen planus (OLP). Methods MEDLINE, Embase, Scopus, Web Science databases were searched for studies published before May 2022, not restricted by publication language or date. The methodological quality risk bias primary‐level critically assessed. Meta‐analyses performed, as well meta‐regression, stratified, sensitivity small‐study effects analyses, Galbraith (radial) plot, trial sequential analysis. Quality evidence was evaluated using GRADE system. Results 104 studies, including 16,587 patients, met inclusion criteria. results show that who suffer from OLP have high (PP = 24.17%, 95% CI 21.45–27.00), low evidence. A significant between also reported (OR 1.28, 1.01–1.63, p 0.04), showing moderate Conclusions Patients could be at an increased suffering which is probably due multiple factors. Healthcare practitioners involved management should aware this comorbidity apply suitable measures make referrals if suspected, although further research needed.

Язык: Английский

Процитировано

7
A Molecular Hypothesis on Malignant Transformation of Oral Lichen Planus: A Systematic Review and Meta-Analysis of Cancer Hallmarks Expression in This Oral Potentially Malignant Disorder DOI Open Access
Carmen Keim-del Pino, Pablo Ramos‐García, Miguel Ángel González‐Moles

и другие.

Cancers, Год журнала: 2024, Номер 16(15), С. 2614 - 2614

Опубликована: Июль 23, 2024

We aimed to qualitatively and quantitatively analyze, through a systematic review meta-analysis, the current evidence on differential expression of hallmarks cancer in oral lichen planus (OLP) samples, order know earliest molecular mechanisms that could be involved malignant transformation this potentially disorder. searched MEDLINE/PubMed, Embase, Web Science, Scopus for studies published before November 2023. evaluated methodological quality carried out meta-analyses fulfill our objectives. Inclusion criteria were met by 110 primary-level studies, with 7065 OLP which 104 biomarkers analyzed immunohistochemistry. Most samples showed sustained cell proliferation signaling (65.48%, 95%CI = 51.87-78.02), anti-apoptotic pathways (55.93%, 35.99-75.0), genome instability (48.44%, 13.54-84.19), tumor-promoting inflammation events (83.10%, 73.93-90.74). Concurrently, also harbored tumor growth suppressor (64.00%, 53.27-74.12). In conclusion, indicates promoting hyperproliferative signaling, an antiapoptotic state genomic instability, escape epithelial cells from immune destruction, are developed LP-affected mucosa. It is plausible these due actions exerted chronic inflammatory infiltrate. Malignant appears prevented genes, consistent upregulation samples.

Язык: Английский

Процитировано

2
Dysplasia in Oral Lichen Planus in a Sample of Egyptians Attending 2 Tertiary Care Centers in Cairo DOI
Fatheya Zahran, Basma Elsaadany, Noha Adel Azab

и другие.

Oral Diseases, Год журнала: 2024, Номер unknown

Опубликована: Окт. 27, 2024

The present retrospective study aimed to evaluate dysplastic changes in oral lichen planus (OLP) lesions and related risk factors a sample of Egyptians. records patients with histological diagnosis OLP, who attended the Oral Medicine Periodontology Department, Faculty Dentistry, Cairo University, British University Egypt, period from 2020 2023 were used. included diagnosed OLP which contained detailed histopathologic descriptions, documented grades dysplasia complete demographic data. Dysplastic graded according latest WHO classification (Neville et al. 2016) by 2 pathologists as records. Patients lichenoid or coexisting tobacco-associated excluded, along those under 18 years age. Ethical approval was acquired Research Ethics Committee at Egypt (24-034). All archives patients' consent for use data published research. that met inclusion criteria 2020–2023 206. Table 1 demonstrates results. proportion both buccal mucosa tongue 39.81%. Palatal all accompanied mucosa. 11 (5.34%) 80 (38.83%) frequency 10.19% (21 out 206 cases) statistically not associated age, gender smoking. results are accordance previous Iran (Irani, Esfahani, Ghorbani 2016), where rate 10.7% revealed, whereas Czerninski (2015) showed figure 12.9% dysplasia, is quite close. According González-Moles (2021), some previously reported values within same range, despite variation studied populations. Previous increased ageing (Ghalwash 2020; Kakoei 2022) supported study. A recent meta-analysis proves smoking an important factor increases malignant transformation (González-Moles Ramos-García 2023). However, our investigation did show influential effect on occurrence following other research (Giuliani 2019). In study, high prevalence females could be cause blurring factor, certain Egyptian socioeconomic levels find it embarrassing confess habit Our erosive type registered highest (p < 0.001), followed atrophic, papular dysplasia. Also, most common site 0.001 p = 0.001, respectively), then gingiva, lips, floor mouth. Thus, Aghbari (2017) regarding lesions. others found no difference between different types potential transformations (Kakoei 2022). Given importance among population seeking care clinics, more should conducted create database statistical information. Fat'heya M. Zahran: conceptualization, investigation, supervision, writing – review editing, curation. Basma Elsaadany: methodology, original draft, Noha Adel Azab: Ayman El-Gawish: Dalia Ghalwash: authors declare conflicts interest. Data sharing applicable this article datasets generated analysed during current

Язык: Английский

Процитировано

1
Possible interplay of diabetes mellitus and thyroid diseases in oral lichen planus: A pooled prevalence analysis DOI Creative Commons
Yun Wang, Xinyi Han,

Laikuan Zhu

и другие.

Journal of Dental Sciences, Год журнала: 2023, Номер 19(1), С. 626 - 630

Опубликована: Ноя. 20, 2023

The existence of a comorbidity between diabetes mellitus (DM) as well thyroid diseases (TD) and oral lichen planus (OLP), respectively, was substantially demonstrated. However, there is not enough attention to the concurrent status both TD DM in OLP patients. Herein, this short communication aimed compare 1) prevalence when concurrently investigated that ignored; 2) ignored studies. pooled (9.86 %; 95 % confidence intervals [CI], 9.22–10.53 %) significantly higher than (8.13 95%CI, 8.03–9.12 (12.48 11.77–13.22 (10.45 9.52–11.46 Thus, it logical presume for first time possible interplay occurrence. should serve important confounding factors each other clinical investigation on associated comorbidities.

Язык: Английский

Процитировано

3
Слизова оболонка порожнини рота – ділянка маніфестації червоного плескатого лишаю та інших захворювань, асоційованих з аутоімунним компонентом DOI Creative Commons

О. В. Авдєєв,

В. Б. Радчук

CLINICAL DENTISTRY, Год журнала: 2024, Номер 4, С. 41 - 46

Опубликована: Фев. 29, 2024

Резюме. Результати напрацювань останніх років дають можливість розглядати слизову оболонку пророжнини рота (СОПР) як ділянку первинної маніфестації значної кількості загальносоматичних захворювань, зокрема, таких, червоний плескатий лишай (ЧПЛ), вульгарна пухирчатка, рецивний афтозний стоматит (РАС), системний вовчак, що, у свою чергу, підкреслює актуальність та своєчасність моніторингу, який планується провести. Мета дослідження – провести моніторинг літературних джерел, що пояснення високої частоти оральної на слизовій оболонці червоного плескатого лишаю, рецидивного афтозного стоматиту шляхом імунологічних характеристик епітеліоцитів. Матеріали і методи. Огляд аналіз наукової медичної літератури основі баз даних Scopus, Web of Science, MedLine, PubMed, NCBI, вивчення яких не перевищує 5 років, включаючи огляди результати клінічних досліджень. досліджень їх обговорення. Будучи частиною системи слизових оболонок, букальний епітелій зберігає елементи її активної позиції взаєминах із дратівливими факторами, виходять зовнішнього внутрішнього середовищ. Це дозволяє використовувати його для фізіології реактивності тому числі індикатор місцевих загальних порушень гомеостазу. Зміна диференціювання епітеліоцитів СОПР спостерігається при великій аутоімунних зокрема ЧПЛ, виникнення якого опосередковане Т-клітинами, якому аутоцитотоксичні CD8+ Т-клітини ініціюють апоптоз базальних СОПР. Доведено роль реалізації імунної відповіді й запалення РАС. Поширеною є гіпотеза, яка базується наявності специфічних білків муцину, які відіграють формуванні захисної оболонки слизової оболонки, слугує першою лінією захисту між епітеліоцитами можливими ініціюючими чинниками з боку порожинин рота. Висновки. Надзвичайно значущою клінічна інформативність цитоспецифічності ЧПЛ РАС, свідчить про реактивність епітелію оболонок загальній системі гомеостазу найбільш доступні елементів клініко-лабораторній практиці.

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0