Oral health risks in users of new generation nicotine/tobacco products (NGPs): Systematic review and qualitative meta-analyses

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Апрель 3, 2024

Abstract Background Use of traditional tobacco products, including combustible cigarettes (CCs) and smokeless oral is an established risk factor for various diseases. A potential health using new generation tobacco/nicotine products (NGPs) such as electronic (ECs), heated (HTPs) nicotine pouches (ONPs) not yet well established. Methods In this systematic review, we evaluated published human studies on detrimental effects in NGP users compared to CC smokers non-users (NU). We identified 52 studies, which almost all investigations were EC users. The extremely heterogeneous terms design, subjects, endpoints quality. Reported outcomes, based both single grouped qualitatively by comparing with NU Significant increases (indicating a worsening health), significant decreases improvement) no difference between groups assigned scores + 1, -1 0, respectively. Results With approach, comparisons versus yielded mean 0.29 (pre-cancerous lesions, N = 14 observations), 0.27 (inflammatory processes, 83), 0.43 (oral clinical parameters, 93) 0.70 (shifts the microbiome, 10). corresponding values amounted to: -0.33 (N 15), -0.14 76), -0.27 78) 0.57 7). Most have severe limitations group sizes, duration use validity self-reported exclusive use. particular, any dual (EC CC) was mostly adequately taken into account. Conclusions suggest that ECs associated some improvement cigarette smoking (CC), but still found be worse NU. These results interpreted caution due number uncertainties underlying studies.

Язык: Английский

Oral health risks in adults who use electronic nicotine delivery systems and oral nicotine pouches: a critical review of the literature and qualitative synthesis of the available evidence

Harm Reduction Journal, Год журнала: 2024, Номер 21(1)

Опубликована: Дек. 31, 2024

Use of combustible cigarettes (CCs) and smokeless oral tobacco products are well documented risk factors for a variety diseases. However, the potential health risks using recently introduced (since about 2000) non-combustible tobacco/nicotine (NCPs: electronic (ECs), heated (HTPs) nicotine pouches (ONPs), remain poorly established.

Язык: Английский