Probiotics as an adjunctive therapy in periodontitis treatment—reality or illusion—a clinical perspective
npj Biofilms and Microbiomes,
Год журнала:
2024,
Номер
10(1)
Опубликована: Дек. 16, 2024
Periodontitis,
a
prevalent
oral
health
issue,
involves
various
microorganisms
and
clinical
effects.
This
review
examines
probiotics
as
adjunctive
therapy
for
periodontitis
by
analyzing
forty
studies.
Findings
showed
mixed
results
due
to
differences
in
study
design,
probiotic
types,
parameters;
however,
improved
outcomes
severe
cases.
Caution
is
advised
when
interpreting
these
results,
longer
follow-up
periods
reveal
variability
potential
regression
Язык: Английский
Inflammation and immune response in the development of periodontal disease: a narrative review
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Ноя. 29, 2024
We
present
this
critical
review
with
the
aim
of
highlighting
current
status
periodontal
diseases,
focusing
on
relevance
host
modulating
agents
and
immune
pathways,
in
addition
to
new
complementary
therapeutic
approaches
for
treatment
these
pathologies.
Periodontal
diseases
are
prevalent
pathologies
worldwide
main
cause
edentulism
adult
population.
Their
pathogenesis
seems
be
based
a
dysbiosis
oral
microbiota
that
interacts
host's
defenses
is
responsible
inflammatory/immune
response,
which
would
modified
by
number
conditions
such
as
individual
susceptibility,
environmental
sociodemographic
factors,
certain
systemic
individual's
genetic
condition,
among
others.
Numerous
studies
have
reported
complex
web
inflammatory
mediators
disease
their
role
tissue
destruction
well
homeostatic
imbalance.
Precisely,
epigenetics
modifier
condition
has
captured
research
attention
recent
years.
Therefore,
mini-review
first
discusses
an
updated
etiological
hypothesis
roles
cytokines
response.
In
addition,
latest
trends
developments
future
perspectives
summarized.
Язык: Английский
The role of azurocidin and its implications in periodontal and peri-implant disease: A systematic review
Archives of Oral Biology,
Год журнала:
2025,
Номер
unknown, С. 106256 - 106256
Опубликована: Апрель 1, 2025
Язык: Английский
Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation
Feilong Ren,
Shize Zheng,
Huanyu Luo
и другие.
International Journal of Oral Science,
Год журнала:
2025,
Номер
17(1)
Опубликована: Апрель 17, 2025
Abstract
Complement
C3
plays
a
critical
role
in
periodontitis.
However,
its
source,
and
underlying
mechanisms
remain
unclear.
In
our
study,
by
analyzing
single-cell
sequencing
data
from
mouse
model
of
periodontitis,
we
identified
that
is
primarily
derived
periodontal
fibroblasts.
Subsequently,
demonstrated
C3a
has
detrimental
effect
ligature-induced
C3ar
−/−
mice
exhibited
significantly
less
destruction
support
tissues
compared
to
wild-type
mice,
characterized
mild
gingival
tissue
damage
reduced
alveolar
bone
loss.
This
reduction
was
associated
with
decreased
production
pro-inflammatory
mediators
osteoclast
infiltration
the
tissues.
Mechanistic
studies
suggested
could
promote
macrophage
polarization
differentiation.
Finally,
patients
found
results
observed
were
consistent
human
data.
Therefore,
findings
clearly
demonstrate
destructive
fibroblast-derived
driven
M1
These
strongly
feasibility
C3a-targeted
interventions
for
treatment
Язык: Английский
Salivary Biomarkers of Inflammasome Activation in Unstable Periodontitis: A Case–Control Study
European Journal of Dentistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 23, 2025
Abstract
The
objective
of
this
study
was
to
investigate
the
complex
network
inflammasome-related
biomarkers
(NOD-like
receptor
thermal
protein
domain
associated
3
[NLRP3],
caspase-1,
interleukin
[IL]-1β,
IL-18,
and
IL-37)
in
unstable
periodontitis
by
examining
salivary
concentrations
these
specific
correlating
them
with
periodontal
parameters.
design
an
observational
case–control
study.
A
sample
collected
from
periodontally
healthy
patients
(n
=
40)
40).
Full-mouth
clinical
parameters
were
recorded
(plaque
index,
bleeding
on
probing,
pocket
depth,
attachment
loss).
Enzyme-linked
immunosorbent
assay
analyzed
NLRP3,
IL-1β,
IL-37
levels.
normality
data
tested
using
Shapiro–Wilk
test.
Mean,
standard
deviation,
percentages
used
for
description.
An
independent
t-test,
Mann–Whitney
U
test,
chi-square
test
compare
two
groups
a
p-value
<
0.05.
Spearman's
correlation
analysis
conducted
examine
relationships
between
variables.
In
saliva
samples,
IL-18
highest
group
(p
0.005),
while
0.005).
There
significant
0.012)
negative
weak
(−0.395)
0.003)
moderate
(−0.455)
group.
(0.031)
positive
(0.342)
found
0.001)
(−0.508)
NLRP3
inflammasomes
their
cytokines
(caspase-1,
IL-18)
significantly
promote
inflammation
tissue
destruction.
contrast,
acts
as
anti-inflammatory
cytokine,
inhibiting
activity
inflammasome
reducing
excessive
inflammation.
This
interplay
highlights
potential
targeting
enhancing
therapeutic
approach
treatment
disease.
Язык: Английский
Fibroblasts derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 18, 2024
Abstract
Complement
C3
plays
a
critical
role
in
periodontitis.
However,
its
source,
and
underlying
mechanisms
remain
unclear.
In
our
study,
by
analyzing
single-cell
sequencing
data
from
mouse
model
of
periodontitis,
we
identified
that
is
primarily
derived
periodontal
fibroblasts.
Subsequently,
demonstrated
C3a
has
detrimental
effect
ligature-induced
C3ar-/-
mice
exhibited
significantly
less
destruction
support
tissues
compared
to
wild-type
mice,
characterized
mild
gingival
tissue
damage
reduced
alveolar
bone
loss.
This
reduction
was
associated
with
decreased
production
pro-inflammatory
mediators
osteoclast
infiltration
the
tissues.
Mechanistic
studies
suggested
could
promote
macrophage
polarization
differentiation.
Finally,
patients
found
results
observed
were
consistent
human
data.
Therefore,
findings
clearly
demonstrate
destructive
fibroblast-derived
driven
M1
These
strongly
feasibility
C3a-targeted
interventions
for
treatment
Язык: Английский
Pattern Recognition Receptors in Periodontal Disease: Molecular Mechanisms, Signaling Pathways, and Therapeutic Implications
Journal of Molecular Pathology,
Год журнала:
2024,
Номер
5(4), С. 497 - 511
Опубликована: Ноя. 13, 2024
Periodontal
disease
remains
a
significant
global
health
concern,
characterized
by
complex
host–pathogen
interactions
leading
to
tissue
destruction.
This
review
explored
the
role
of
pattern
recognition
receptors
(PRRs)
in
pathogenesis
periodontal
disease,
synthesizing
current
knowledge
on
their
molecular
mechanisms
and
potential
as
therapeutic
targets.
We
examined
diverse
family
PRRs,
focusing
toll-like
(TLRs)
NOD-like
(NLRs),
elucidating
activation
pathogens
subsequent
downstream
signaling
cascades.
highlights
intricate
interplay
between
PRR-mediated
pathways,
including
NF-κB
MAPK
signaling,
impact
inflammatory
responses
bone
metabolism
tissues.
discussed
emerging
concept
PRR
crosstalk
its
implications
for
homeostasis
progression.
Furthermore,
this
addressed
PRR-targeted
therapies,
exploring
both
challenges
opportunities
translating
insights
into
clinical
applications.
By
providing
an
overview
PRRs
aims
stimulate
future
research
directions
inform
development
novel
diagnostic
strategies
periodontology.
Язык: Английский