Malignant Transformation Rate of Oral Premalignant Disorders: A Large Database Analysis DOI Creative Commons
Andrew Meci, Neerav Goyal, David Goldenberg

и другие.

The Laryngoscope, Год журнала: 2025, Номер unknown

Опубликована: Май 10, 2025

ABSTRACT Objectives Oral leukoplakia (OL), oral lichen planus (OLP), and submucous fibrosis (OSF) are precancerous lesions known to progress squamous cell carcinoma (OSCC). The transformation rates OSCC controversial have been based on small, heterogeneous, single‐institution studies. We present the largest study date looking at malignant of these premalignant disorders (OPMD). Methods conducted a retrospective cohort within TriNetX database. Patients aged ≥ 18 with diagnosis OL, OLP, OSF between 2008 2018 were included, allowing for up 5 years follow‐up. primary outcome was 5‐year rate compared control cohort. Secondary outcomes included treatment pathways survival. Descriptive comparative statistics using software. Results Totally, 59,204 patients diagnosed or included. average age all 55.8 ± 14.1; majority female ( n = 31,805, 53.7%) white 33,867, 57.2%). Rates nicotine alcohol dependence 8.7% 2.8%, respectively. 15.6%, 1.4%, 18.6% p < 0.01 control), an overall 6.2% control). Kaplan–Meier survival probability 94.3%. Conclusions Our results indicate which OPMD (OL, OSF) higher than previously reported. Transformation OL in particular underscore need close monitoring prompt avoid transformation. Level Evidence Retrospective study—Level 3.

Язык: Английский

Letter to the Editor: “A Deep Learning System to Predict Epithelial Dysplasia in Oral Leukoplakia” DOI Creative Commons
José Manuel Aguirre Urízar, Irene Lafuente‐Ibáñez de Mendoza

Journal of Dental Research, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

Процитировано

1
Artificial intelligence and the diagnosis of oral cavity cancer and oral potentially malignant disorders from clinical photographs: a narrative review DOI Creative Commons

Payam Mirfendereski,

Grace Y. Li,

Alexander T. Pearson

и другие.

Frontiers in Oral Health, Год журнала: 2025, Номер 6

Опубликована: Март 10, 2025

Oral cavity cancer is associated with high morbidity and mortality, particularly advanced stage diagnosis. cancer, typically squamous cell carcinoma (OSCC), often preceded by oral potentially malignant disorders (OPMDs), which comprise eleven variable risks for transformation. While OPMDs are clinical diagnoses, conventional exam followed biopsy histopathological analysis the gold standard diagnosis of OSCC. There vast heterogeneity in presentation OPMDs, possible visual similarities to early-stage OSCC or even various benign mucosal abnormalities. The diagnostic challenge OSCC/OPMDs compounded non-specialist primary care setting. has been significant research interest technology assist OSCC/OPMDs. Artificial intelligence (AI), enables machine performance human tasks, already shown promise several domains medical diagnostics. Computer vision, field AI dedicated data, over past decade applied photographs Various methodological concerns limitations may be encountered literature on OSCC/OPMD image analysis. This narrative review delineates current landscape photograph navigates limitations, issues, workflow implications this field, providing context future considerations.

Язык: Английский

Процитировано

1
Comparative Clinical and Histopathological Study of Oral Leukoplakia in Smokers and Non-Smokers DOI Creative Commons
Andrei-Eduard Șerban, Ioanina Părlătescu, Elena Milanesi

и другие.

Diagnostics, Год журнала: 2025, Номер 15(4), С. 502 - 502

Опубликована: Фев. 19, 2025

Background/Objectives: Oral leukoplakia (OLK) is an oral mucosal lesion classified in the potentially malignant disorder group and associated with increased risk of transformation (MT). The aim this study was to compare clinical histopathological features two OLK groups, a smokers non-smokers. Methods: In retrospective study, cohort 154 patients divided into groups based on presence smoking as major factor. diagnoses were established via examination. Results: Females more abundant non-smoking than group, where males (p < 0.001). average age lower that non-smokers = 0.003). smokers, buccal mucosa most frequently affected, while non-smokers, gums tongue primarily involved 0.016). female involvement area multiple-site statistically significantly observed compared 0.006). Non-dysplastic lesions predominant both severe dysplasia smokers. MT higher non-smoker smoker group. Conclusions: different from concerning gender involvement, site location, number lesions, rate.

Язык: Английский

Процитировано

0
Malignant Transformed and Non-Transformed Oral Leukoplakias Are Metabolically Different DOI Open Access
Roberta Rayra Martins‐Chaves, Victor Coutinho Bastos, Jéssica Gardone Vitório

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1802 - 1802

Опубликована: Фев. 20, 2025

Understanding the early molecular events driving oral carcinogenesis is vital for diagnosing squamous cell carcinoma (OSCC) promptly. While metabolic differences between leukoplakia (OLK), OSCC, and healthy mucosa have been reported, changes distinguishing malignant transformed OLKs (MT-OLK) from non-transformed (NT-OLK) remain unexplored. Here, we examine metabolomic profiles of 5 cases MT-OLK 15 NT-OLK to identify key predictive molecules using untargeted high-performance liquid chromatography-mass spectrometry. The potentially discriminant compounds were highlighted through a robust statistical analysis workflow, dysregulated pathways illustrated by enrichment analysis. Seventeen features, primarily lipids-including phospholipids, oxidised lipids, cholesteryl esters, fatty acids-were identified as discriminants across bioinformatic approaches. Pathway revealed alterations in lipid metabolism, particularly acid synthesis degradation, steroid hormone biosynthesis, glycerophospholipid metabolism. Predictive models showed high accuracy (AUC = 0.88) two groups. This study suggests that metabolomics has potential differentiate identifying candidate biomarkers may contribute understanding transformation. Validation larger cohorts warranted translate these findings into clinical practice.

Язык: Английский

Процитировано

0
Significance of Epidermal Growth Factor Receptor (EGFR) upregulation in the prediction of the malignant transformation risk in oral potentially malignant disorders: a systematic review and meta-analysis DOI Creative Commons

José Luis Cívico-Ortega,

Pablo Ramos‐García, Miguel Ángel González‐Moles

и другие.

Frontiers in Oral Health, Год журнала: 2025, Номер 6

Опубликована: Март 27, 2025

Objectives The purpose of this systematic review and meta-analysis was to appraise, both quantitatively qualitatively, the extant evidence regarding role EGFR upregulation in predicting malignant transformation risk associated with oral potentially disorders (OPMD). Methods A comprehensive search undertaken Web Science, Embase, MEDLINE (via PubMed), Scopus databases for longitudinal primary-level articles, whether prospective or retrospective design, without restrictions on language publication date. QUIPS tool employed assessing potential bias. conducted addition sensitivity analyses influence small-study effects. Results In total, eight studies, which were treated as nine distinct units analytical purposes, included final sample, encompassed 653 patients OPMD follow-up data. found be significantly an elevated (RR = 2.17, 95%CI 1.73–2.73, p &lt; 0.001). Subgroup demonstrated that protein overexpression 2.02, 1.55–2.63, 0.001) gene amplification 2.70, 1.72–4.25, 0.001), nuclear staining 3.47, 1.50-8.01, 0.004) &gt;10% cutoff point 2.27, 1.33–3.87, 0.003). Conclusion present demonstrates overexpression, assessed through immunohistochemical technique, functions a marker risk. Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/view/CRD42024626482 , identifier: CRD42024626482).

Язык: Английский

Процитировано

0
Binary‐ and Three‐Tiered Oral Epithelial Dysplasia Grading System and Malignant Transformation DOI

Riikka Ellonen,

Jetta Kelppe, Jaana Hagström

и другие.

Oral Diseases, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

ABSTRACT Objectives Oral epithelial dysplasia (OED) can be graded histopathologically by using a binary‐ or three‐tiered grading system. This study aimed to analyze and compare the prognostic value of two systems in large single‐institute material. Materials Methods The was retrospective histopathological re‐evaluation analysis 612 OEDs over 29 years at Institute Dentistry, University Turku, Finland. OED patients who later developed squamous cell carcinoma (OSCC) were identified from Finnish Cancer Registry database. Results Altogether, mean age 59.9 years. male:female ratio 0.67. According original diagnosis, 67.7% samples mild dysplasia, 28.7% moderate 3.6% severe cases. With binary‐tiered low‐grade 84.1% more common than high‐grade 15.9%. malignant transformation rate 7.8%. Regarding oral SCC development, no difference found between predicting progression ( p = 0.060). Conclusions Both classification had similar predictive for transformation.

Язык: Английский

Процитировано

0
Advances in Photothermal Therapy for Oral Cancer DOI Open Access
Jian Liang, Pei Wang, Yanjun Lin

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(9), С. 4344 - 4344

Опубликована: Май 2, 2025

Oral cancer represents a critical global health issue, where traditional treatment modalities are often characterized by considerable adverse effects and suboptimal effectiveness. Photothermal therapy (PTT) offers an innovative method for tumor treatment, leveraging photothermal agents to convert light into hyperthermia, ultimately leading ablation. PTT unique advantages in treating oral due its superficial anatomical location consequent accessibility laser irradiation. PTT’s advantage is further enhanced capacity facilitate drug release promote tissue regeneration. Consequently, the application of has garnered widespread interest undergone rapid development. This review outlines advances cancer, emphasizing strategies improve efficacy combination approaches. The key challenges, including temperature control long-term biosafety, discussed alongside future directions. also encompasses role managing potentially malignant disorders postoperative defects, conditions intimately linked with cancer. We aim provide guidance emerging research development precise efficient strategies.

Язык: Английский

Процитировано

0
Malignant Transformation Rate of Oral Premalignant Disorders: A Large Database Analysis DOI Creative Commons
Andrew Meci, Neerav Goyal, David Goldenberg

и другие.

The Laryngoscope, Год журнала: 2025, Номер unknown

Опубликована: Май 10, 2025

ABSTRACT Objectives Oral leukoplakia (OL), oral lichen planus (OLP), and submucous fibrosis (OSF) are precancerous lesions known to progress squamous cell carcinoma (OSCC). The transformation rates OSCC controversial have been based on small, heterogeneous, single‐institution studies. We present the largest study date looking at malignant of these premalignant disorders (OPMD). Methods conducted a retrospective cohort within TriNetX database. Patients aged ≥ 18 with diagnosis OL, OLP, OSF between 2008 2018 were included, allowing for up 5 years follow‐up. primary outcome was 5‐year rate compared control cohort. Secondary outcomes included treatment pathways survival. Descriptive comparative statistics using software. Results Totally, 59,204 patients diagnosed or included. average age all 55.8 ± 14.1; majority female ( n = 31,805, 53.7%) white 33,867, 57.2%). Rates nicotine alcohol dependence 8.7% 2.8%, respectively. 15.6%, 1.4%, 18.6% p < 0.01 control), an overall 6.2% control). Kaplan–Meier survival probability 94.3%. Conclusions Our results indicate which OPMD (OL, OSF) higher than previously reported. Transformation OL in particular underscore need close monitoring prompt avoid transformation. Level Evidence Retrospective study—Level 3.

Язык: Английский

Процитировано

0