Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics
Journal of Fungi,
Год журнала:
2025,
Номер
11(2), С. 93 - 93
Опубликована: Янв. 24, 2025
Metabolomics
has
emerged
as
a
transformative
tool
in
the
study
of
microbes,
including
pathogenic
fungi,
facilitating
identification
unique
metabolic
profiles
that
elucidate
their
mechanisms,
host
interactions,
and
treatment
resistance.
This
review
highlights
key
applications
metabolomics
understanding
fungal
metabolites
essential
for
human
virulence,
such
mycotoxins
produced
by
various
species,
Aspergillus
fumigatus
(gliotoxin,
fumagillins)
Candida
species
(phenylethyl
alcohol,
TCA
cycle
metabolites),
secondary
contribute
to
pathogenicity.
It
also
explores
adaptations
fungi
relation
drug
resistance
biofilm
formation,
revealing
alterations
pathways
during
infection,
seen
C.
albicans
auris.
Furthermore,
aids
deciphering
host–pathogen
showcasing
how
like
Cryptococcus
neoformans
modify
metabolism
promote
survival
evade
immune
responses.
The
antifungal
mechanisms
benefited
from
metabolomic
approaches,
identifying
specific
metabolite
patterns
signify
resistance,
Candidozyma
(Candida)
auris,
informing
new
therapeutic
strategies.
integration
with
other
omics
technologies
is
paving
way
comprehensive
biology
pathogenesis.
Such
multi-omics
approaches
are
crucial
discovering
targets
developing
innovative
treatments.
Thus,
purpose
this
provide
an
overview
revolutionizing
our
pathogenesis,
highlight
its
potential
improving
Язык: Английский
Deciphering the Interplay between the Epithelial Barrier, Immune Cells, and Metabolic Mediators in Allergic Disease
Lea Ling‐Yu Kan,
Peiting Li,
Sharon Sze-Man Hon
и другие.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 6913 - 6913
Опубликована: Июнь 24, 2024
Chronic
exposure
to
harmful
pollutants,
chemicals,
and
pathogens
from
the
environment
can
lead
pathological
changes
in
epithelial
barrier,
which
increase
risk
of
developing
an
allergy.
During
allergic
inflammation,
cells
send
proinflammatory
signals
group
2
innate
lymphoid
cell
(ILC2s)
eosinophils,
require
energy
resources
mediate
their
activation,
cytokine/chemokine
secretion,
mobilization
other
cells.
This
review
aims
provide
overview
metabolic
regulation
asthma,
atopic
dermatitis
(AD),
rhinitis
(AR),
highlighting
its
underlying
mechanisms
phenotypes,
potential
regulatory
roles
eosinophils
ILC2s.
Eosinophils
ILC2s
regulate
inflammation
through
lipid
mediators,
particularly
cysteinyl
leukotrienes
(CysLTs)
prostaglandins
(PGs).
Arachidonic
acid
(AA)-derived
metabolites
Sphinosine-1-phosphate
(S1P)
are
significant
markers
that
indicate
immune
dysfunction
barrier
Notably,
promoters
symptoms
exhibit
greater
plasticity
compared
ILC2s,
directly
involved
promoting
symptoms.
Our
findings
suggest
metabolomic
analysis
provides
insights
into
complex
interactions
between
cells,
environmental
factors.
Potential
therapeutic
targets
have
been
highlighted
further
understand
Future
research
metabolomics
facilitate
development
novel
diagnostics
therapeutics
for
future
application.
Язык: Английский
Editorial comment on “Immunomodulatory metabolites in IgE‐mediated food allergy and oral immunotherapy outcomes based on metabolomic profiling”
Pediatric Allergy and Immunology,
Год журнала:
2025,
Номер
36(1)
Опубликована: Янв. 1, 2025
image
Язык: Английский
Exposome Study for Allergic Diseases in Children: Rationale and Design of ECHO-COCOA Study
Опубликована: Янв. 1, 2025
Язык: Английский
Editorial comment on the special issue “Omics in food allergy”
Pediatric Allergy and Immunology,
Год журнала:
2024,
Номер
35(3)
Опубликована: Март 1, 2024
The
peer
review
history
for
this
article
is
available
at
https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/pai.14113.
Язык: Английский
Navigating the changing landscape of pediatric allergies in the Asia Pacific region
Pediatric Allergy and Immunology,
Год журнала:
2024,
Номер
35(9)
Опубликована: Сен. 1, 2024
None
declared.
The
peer
review
history
for
this
article
is
available
at
https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/pai.14229.
Язык: Английский