Cited by Editorial: New insights in pediatric gastrointestinal food allergies

Editorial: New insights in pediatric gastrointestinal food allergies DOI

и другие.

Frontiers in Allergy, Год журнала: 2024, Номер 5

Опубликована: Дек. 11, 2024

Pediatric food allergies (FA) are a significant and growing health concern, especially in developed countries. The most recent data on FA epidemiology children, depicts dramatic picture terms of prevalence, incidence, severity (1,2). Food allergy derives from negative interaction between genetic background environmental factors, leading to breakdown immune tolerance antigens (3).During the last decades one impressive changes factors was related increased exposure ultraprocessed foods (UPF), as underlined paper by Carucci et al. included this issue. In Western countries, consumption UPF has at alarming rate, so that more than half total daily dietary energy intake children (3,4). ready use foods, their palatability, low costs well eye-catching appearance, make very attractive. At same time have poor nutritional profile, being highly processed, rich sugar, fat fibers (3,5).The highlights mechanistic role UPF, pathogenesis eosinophilic esophagitis (EoE). authors underline how specific component (i.e., advanced glycation end products) activating alarmin signal cause alteration epithelial barrier with subsequent abnormal allergen activation type 2 (Th2) inflammation. result pathway may direct "switch on" EoE inflammation, also demonstrated clinical preclinical (3,5,6). These could be relevant for defining innovative strategies preventing managing EoE.The interesting review Nuyttens elucidate pathophysiology gastrointestinal classifying IgE-, non-IgE-mediated, mixed forms, based mechanisms (7).Despite presence/absence IgE against failure gut microbiome (GM) alterations mainstay (8).The pivotal GM system led concept "GM-immune axis" (9). This mutual dynamic starts early life, beginning first 1000 days, crucial frame which axis is extremely vulnerable. During period several negatively or positively influence axis, setting basis current future status child (3,10) Some influencing structure function life (e.g., caesarean delivery, antibiotics proton pump inhibitors use, consumption, anti-septic agents exposure) leads decrease microbial diversity, dysfunctional GM, resulting lower production immunomodulatory compounds such short chain fatty acids butyrate) playing regulating differentiation regulatory T (Treg) cells.(3,10,11) (Fig. 1).The breakthrough paradigm shift prevention. Indeed, many years, avoidance prevention infants risk; but evidence suggests delaying introduction allergenic not prevent sensitization even increase risk developing FA, described research topic (7). Accordingly, EAACI recommendations prevention, emphasize protective high (12).In addition, avoiding drugs antibiotics, inhibitors), promoting breastfeeding, diet fibres, fermented antioxidants, omega-3 mother babies, effective (3,10). 1).In provided Leone al., management pediatric been only strict identified allergens, years. For cow's milk (CMA) management, addition CM avoidance, substitutes formula CMA treatment, different formulae Robert E. al, comparing opinions group Middle East expert those European Society Paediatric Gastroenterology, Hepatology Nutrition (ESPGHAN) experts, symptoms (13). decades, "GM changed passing passive pro-active approach (10).The modern requires personalized aimed education about ensure an optimal growth development; it includes active therapy approach, exploiting ability some modulate potentially facilitating occurrence (10,14).Lastly, et. other therapies, oral immunotherapy (OIT), described, offering new hope gradually desensitizing through controlled antigen exposure, help biological therapies reduce potential side effects therapeutic efficacy OIT (14). Based important all impacting gut-microbiome (red arrow) beneficial able (green arrows). Once developed, needs managed multistep including A) Dietary (allergen substitutes, healthy diet); B) Adequate macro micro-nutrients (stimulation body development); C) Active tolerance).

Язык: Английский

Role of the microbiome in regulation of the immune system DOI

Songhui Kim,

Cebile Ndwandwe,

Hannah Devotta

и другие.

Allergology International, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Immune health and metabolic functions are intimately connected via diet the microbiota. cells continuously exposed to a wide range of microbes microbial-derived compounds, with important mucosal systemic ramifications. Microbial fermentation dietary components in vivo generates thousands molecules, some which integral molecular circuitry that regulates immune functions. These turn protect against aberrant inflammatory or hyper-reactive processes promote effector responses quickly eliminate pathogens, such as SARS-CoV-2. Potent tolerance mechanisms should ensure these do not over-react non-pathogenic factors (e.g. food proteins), while maintaining ability respond infectious challenges robust, effective well controlled manner. In this review we examine shape microbiota composition interactions host system, their associations mediated disorders strategies for intervention.

Язык: Английский

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Editorial comment on “Diversity of complementary diet and early food allergy risk” DOI

Gonçalo Silva, Philippe Eigenmann, Rachel L. Peters

и другие.

Pediatric Allergy and Immunology, Год журнала: 2025, Номер 36(2)

Опубликована: Фев. 1, 2025

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Язык: Английский

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Nouvelles sources protéiques et nouveaux allergènes : sensibilisation de novo et réactivité croisée DOI

Stéphane Hazebrouck,

Y. L. Awad,

Hervé Bernard

и другие.

Revue française d'allergologie, Год журнала: 2025, Номер 65(3), С. 104203 - 104203

Опубликована: Фев. 15, 2025

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The roles of bitter and sweet taste receptors in food allergy: Where are we now? DOI

Mo Xian, Anish Maskey,

Daniel Kopulos

и другие.

Allergology International, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Food allergy (FA) is a growing global concern, which contributes significantly to anaphylaxis and severe allergic reactions. Despite advancements in treatments like allergen immunotherapy biologics, current approaches have notable limitations there pressing need for new therapeutic strategies. Recent research into taste receptors has unveiled their potential role FA, offering fresh perspectives understanding managing this condition. Taste receptors, particularly type 1 (TAS1Rs/T1Rs, sweet receptors) 2 (TAS2Rs/T2Rs, bitter receptors), are distributed not only the oral cavity but also various extra-oral tissues, interactions with immune responses increasingly recognized. This review highlights connections between exploring how receptor mechanisms might contribute FA pathogenesis treatment. especially TAS2Rs, include multiple subtypes varying ligand specificities, been implicated modulating could serve as targets novel therapies. Additionally, compounds such agents sweeteners that interact show promise influencing outcomes. emphasizes further of involvement suggests targeting these provide avenues intervention future.

Язык: Английский

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Emerging concepts in introducing foods for food allergy prevention DOI

Carina Venter, Marion Groetch

Current Opinion in Clinical Nutrition & Metabolic Care, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

This review focuses on the latest information regarding role of complementary feeding practices and food allergen introduction in prevention allergies. Early allergens for allergy is recommended by guidelines supported randomized controlled trials. Diet diversity recommended, studies from Asia. A European study indicated that diet after first year life may still be important prevention. The systematic reviews indicate there an association between ultra-processed intake development. Plant based foods fiber play modulating gut microbiome which has been associated with reduced outcomes. However, increased within a diverse raises questions about excessive calorie protein but can managed focusing infant satiety cues. clearly further supports allergies should not delayed once commenced. to support

Язык: Английский

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The Epithelial Barrier Hypothesis in Food Allergies: The State of the Art DOI

Valentina Ferraro,

Stefania Zanconato,

Silvia Carraro

и другие.

Nutrients, Год журнала: 2025, Номер 17(6), С. 1014 - 1014

Опубликована: Март 14, 2025

Recently, the “epithelial barrier hypothesis” has been proposed as a key factor in development of allergic diseases, such food allergies. Harmful environmental factors can damage epithelial barriers, with detrimental effects on host immune response and local microbial equilibrium, resulting chronic mucosal inflammation that perpetuates dysfunction barrier. The increased permeability allows allergens to access submucosae, leading an imbalance between type 1 T-helper (Th1) 2 (Th2) inflammation, predominant Th2 is allergy development. In this article state art, we review scientific evidence hypothesis”, focus We describe how loss integrity skin intestinal modifications gut microbiota composition contribute inflammatory changes immunological unbalance lead

Язык: Английский

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The Impact of Dietary Counseling on the Nutritional Status of Pediatric Patients with Non-IgE-Mediated Gastrointestinal Food Allergies: A Non-Randomized, Prospective Intervention Study DOI

Serena Coppola, Laura R. Carucci,

Alessandra Agizza

и другие.

Nutrients, Год журнала: 2025, Номер 17(6), С. 1080 - 1080

Опубликована: Март 19, 2025

Background/Objectives: Pediatric patients with non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFAs) may experience alterations of nutritional status. This non-randomized, prospective intervention study investigated the impact dietary counseling on status in pediatric non-IgE-GIFAs. Methods: Patients both sexes aged 0–14 years newly diagnosed non-IgE-GIFAs received provided by certified dietitians immediately after diagnosis. Nutritional parameters were assessed to identify at baseline and 12 months (T12). Results: The included 100 (58% male, mean age 8.5 ± 8.8 months). Non-IgE-GIFAs phenotypes protein-induced enteropathy (FPE, 44%), enterocolitis syndrome (FPIES, 11%), allergic proctocolitis (FPIAP, 17%), motility disorders (FPIMD, 28%). At diagnosis, 1% was affected obesity (1 FPIAP), 5% overweight (2 FPE, 1 FPIAP, 2 FPIMD), 7% moderately underweight (5 FPE severely FPE), stunted (4 16% wasted (11 FPIES, 3 4% FPIMD). T12, improvements anthropometric observed, along a reduction prevalence malnutrition excess (6% diagnosis vs. 2% T12) undernutrition subtypes rate, including underweight, stunting, wasting (26% 3% p < 0.001). Conclusions: can negatively patients. Thus, could be an effective strategy for preventing managing these

Язык: Английский

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Adherence to the Mediterranean diet and allergic diseases in Korean adults: KNHANES 2013–2016 DOI

Kathryn Choon Beng Tan,

Ning Sun,

Jiaojiao Chen

и другие.

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 7, 2025

The prevalence of allergic diseases [e.g., asthma, rhinitis (AR), atopic dermatitis (AD)] has increased significantly in recent years, which is coincides with a shift modern eating habits. Mediterranean diet, due to its anti-inflammatory properties, may be beneficial the prevention diseases. However, effects on have not been sufficiently studied. We investigated relationship between adherence diet and This study analyzed (using modified score, mMED) dermatitis, 12,080 participants using data from 2013-2016 Korean National Health Nutrition Examination Survey (KNHANES). Multiple logistic regression analyses were used control for confounding factors such as age, gender, education level, income, lifestyle. In multivariable adjusted models, higher mMED had lower risk developing AD (OR 0.57; 95% CI, 0.36-0.92; p trend = 0.0201). When stratified by sex, this reduction was more significant females 0.50; 0.27-0.96; <0.05). Across components, fish peanut intake negatively associated occurrence AR 0.55; 0.40-0.76; <0.05, OR 0.75; 0.65-0.87; There no association asthma scores. High especially women. Fish an important protective role against

Язык: Английский

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Contribuição da agricultura familiar para a Segurança Alimentar e Nutricional DOI

Natalie Marinho Dantas, Camila Valdejane Silva de Souza, Diôgo Vale

и другие.

Segurança Alimentar e Nutricional, Год журнала: 2025, Номер 31, С. e024035 - e024035

Опубликована: Апрель 4, 2025

Introdução: Para o sucesso das ações públicas relacionadas à promoção da Segurança Alimentar e Nutricional (SAN) ao desenvolvimento sustentável, é essencial que exista uma diversidade de alimentos produzidos pela agricultura familiar (AF) nos diferentes territórios brasileiros. Nesse sentido, reconhecimento nas diversas regiões brasileiras pode ser um recurso importante para direcionamento políticas públicas. Objetivo: Analisar a distribuição espacial dos origem vegetal AF em do Brasil. Métodos: Trata-se estudo descritivo exploratório partir dados secundários sobre produção obtidos Censo Agropecuário (2017) realizado pelo Instituto Brasileiro Geografia Estatística. Realizou-se análises descritivas espaciais total no Brasil Regiões Geográficas Intermediárias (RGI). Resultados: Os mais foram milho grão, macaxeira (mandioca, aipim) soja grão. As RGI produziram média 57 alimentos. A apresentou forte correlação (p<0,05) com formação cluster maior variedade Sudeste menor Nordeste brasileiro. Discussão: rurais apresentam baixa na esbarram restrições desse setor agrícola, além serem afetados prevalência Insegurança Alimentar. Conclusão: achados apontam necessidade incentivo soberania alimentar por meio públicas, vistas garantia SAN.

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Editorial comment on “The Naples pediatric food allergy score: A multivariable model for the prediction of food allergy in children” DOI

Martina Votto, Rachel L. Peters, Philippe Eigenmann

и другие.

Pediatric Allergy and Immunology, Год журнала: 2025, Номер 36(4)

Опубликована: Апрель 1, 2025

image

Язык: Английский

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