Molecular allergen sensitization drives phenotypes of severe asthma in children: Evidence from a megacity cohort (SAMP) DOI Creative Commons
M. Bourgoin‐Heck,

Victoria Wolff‐Goldnadel,

Yannick Chantran

и другие.

Pediatric Allergy and Immunology, Год журнала: 2024, Номер 35(12)

Опубликована: Дек. 1, 2024

Abstract Background Several major sensitization profiles have been described in children with asthma, but it remains unclear how these relate to asthma phenotypes. The aim of this study was determine allergenic a megacity cohort (SAMP). Methods This cross‐sectional analysis performed from 2011 2015 including preschool and school‐age severe moderate the SAMP cohort. We ALEX multiplex array carried out cluster analysis. Results Data 367 were analyzed: 224 age 143 school age, respectively 84 (38%) 114 (80%) presented at least one allergic sensitization. At three clusters identified: Cluster 1, Few sensitizations inhaled allergen molecular families non‐type 2 (T2) inflammation ( n = 61); 2, Predominant HDM 16); 3, Severe multiple food 7). five non‐T2 43); 31); PR‐10 protein family 25); 4, predominant tropomyosin 11); 5, 4). Conclusion These results underline heterogeneity childhood asthma. most phenotypes associated both as expected, family, novel finding.

Язык: Английский

Molecular allergen sensitization drives phenotypes of severe asthma in children: Evidence from a megacity cohort (SAMP) DOI Creative Commons
M. Bourgoin‐Heck,

Victoria Wolff‐Goldnadel,

Yannick Chantran

и другие.

Pediatric Allergy and Immunology, Год журнала: 2024, Номер 35(12)

Опубликована: Дек. 1, 2024

Abstract Background Several major sensitization profiles have been described in children with asthma, but it remains unclear how these relate to asthma phenotypes. The aim of this study was determine allergenic a megacity cohort (SAMP). Methods This cross‐sectional analysis performed from 2011 2015 including preschool and school‐age severe moderate the SAMP cohort. We ALEX multiplex array carried out cluster analysis. Results Data 367 were analyzed: 224 age 143 school age, respectively 84 (38%) 114 (80%) presented at least one allergic sensitization. At three clusters identified: Cluster 1, Few sensitizations inhaled allergen molecular families non‐type 2 (T2) inflammation ( n = 61); 2, Predominant HDM 16); 3, Severe multiple food 7). five non‐T2 43); 31); PR‐10 protein family 25); 4, predominant tropomyosin 11); 5, 4). Conclusion These results underline heterogeneity childhood asthma. most phenotypes associated both as expected, family, novel finding.

Язык: Английский

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