Natural Products Modulating Mitophagy Implications for Cancer Therapy DOI
Manish Kumar Verma

IGI Global eBooks, Год журнала: 2025, Номер unknown, С. 255 - 282

Опубликована: Июнь 5, 2025

Mitochondrial dysfunction is a hallmark of cancer, contributing to tumorigenesis, and therapeutic resistance. Mitophagy, the selective removal damaged or dysfunctional mitochondria, plays crucial role in maintaining cellular homeostasis preventing accumulation stress. The dysregulation mitophagy cancer often leads promoting tumorigenesis hampering efficacy conventional therapies. Natural products like polyphenols, flavonoids, alkaloids, terpenoids influencing mitophagy, through AMP-activated protein kinase (AMPK), mTORC1, PINK1/Parkin-mediated pathways offer promising strategy restore mitochondrial enhance sensitivity cells treatment. In conclusion, understanding intricate interplay between natural provides insights into novel strategies for diseases associated with dysfunction.

Язык: Английский

Emerging Trends in Secondary Metabolite Research in Caryophyllales: Betalains and Their Roles in Plant Adaptation and Defense Mechanisms DOI
Irfan Ali Sabir, Muhammad Aamir Manzoor, Imran Khan

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Betalains, a distinctive group of nitrogen-containing pigments exclusive to the Caryophyllales order, possess diverse biological activities such as antioxidant, anti-inflammatory, and antimicrobial properties, making them highly valuable for applications in food, nutraceutical, pharmaceutical industries. This Review provides comprehensive analysis betalain biosynthesis, structural diversity, ecological significance, highlighting their roles enhancing stress resilience, adaptation mechanisms, plant evolutionary strategies. The development betalains is explored, revealing emergence through gene duplication events providing insights into mutual exclusivity with anthocyanins. study utilizes comparative genetics advanced molecular tools uncover intricate regulatory networks involving transcription factors MYB, bHLH, WRKY, SPL, which govern biosynthesis. Furthermore, discusses innovative transgenic studies that introduce non-native species, demonstrating potential enhance tolerance boost agricultural productivity. While significant progress has been made understanding biosynthesis pathways, relationships anthocyanins specific functions plants remain areas ongoing exploration. Future research directions include integrating chemotaxonomic studies, phylogenetics, multiomics approaches unravel full spectrum mechanisms. Such are essential deepening our these vibrant implications, offering new opportunities biotechnological innovations sustainable practices. stands out by combining genetic, ecological, perspectives, novel multifunctionality drive future advancements science biotechnology.

Язык: Английский

Процитировано

2

Genetic mechanisms, biological function, and biotechnological advance in sorghum tannins research DOI
Fu Wang, Qian Zhao, Shuyao Li

и другие.

Biotechnology Advances, Год журнала: 2025, Номер unknown, С. 108573 - 108573

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

Chromatic symphony of fleshy fruits: functions, biosynthesis and metabolic engineering of bioactive compounds DOI Creative Commons
Huimin Hu, Nirakar Pradhan, Jianbo Xiao

и другие.

Molecular Horticulture, Год журнала: 2025, Номер 5(1)

Опубликована: Апрель 2, 2025

Fleshy fruits are popular among consumers due to their significant nutritional value, which includes essential bioactive compounds such as pigments, vitamins, and minerals. Notably, plant-derived pigments generally considered safe reliable, helping protect humans against various inflammatory diseases. Although the phytochemical diversity biological activities have been extensively reviewed summarized, status of nutrients in fleshy fruits, particularly with a focusing on different colors, has received less attention. Therefore, this review introduces five common types based coloration summarizes major compounds. It also provides latest advancements function, biosynthesis, metabolic engineering pigments. In review, we emphasize that promoting consumption diverse array colorful can contribute balanced diet; however, optimal intake levels still require further clinical validation. This may serve useful guide for decisions enhance understanding natural accelerate application agriculture medicine.

Язык: Английский

Процитировано

0

Enhanced production of C50 carotenoid bacterioruberin by metabolically engineered Corynebacterium glutamicum DOI
Eui‐Sang Cho, Chi Young Hwang, Myung‐Ji Seo

и другие.

Bioresource Technology, Год журнала: 2025, Номер unknown, С. 132670 - 132670

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Mannich base derivatives in neurological disorders: A comprehensive review with SAR approach DOI
S. K. Srivastava,

Avinash C. Tripathi,

Mayank Yadav

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер 1343, С. 142669 - 142669

Опубликована: Июнь 5, 2025

Язык: Английский

Процитировано

0

Natural Products Modulating Mitophagy Implications for Cancer Therapy DOI
Manish Kumar Verma

IGI Global eBooks, Год журнала: 2025, Номер unknown, С. 255 - 282

Опубликована: Июнь 5, 2025

Mitochondrial dysfunction is a hallmark of cancer, contributing to tumorigenesis, and therapeutic resistance. Mitophagy, the selective removal damaged or dysfunctional mitochondria, plays crucial role in maintaining cellular homeostasis preventing accumulation stress. The dysregulation mitophagy cancer often leads promoting tumorigenesis hampering efficacy conventional therapies. Natural products like polyphenols, flavonoids, alkaloids, terpenoids influencing mitophagy, through AMP-activated protein kinase (AMPK), mTORC1, PINK1/Parkin-mediated pathways offer promising strategy restore mitochondrial enhance sensitivity cells treatment. In conclusion, understanding intricate interplay between natural provides insights into novel strategies for diseases associated with dysfunction.

Язык: Английский

Процитировано

0