Relationships between clinician adherence to guideline-recommended treatment and memory function in patients with schizophrenia
Journal of Psychiatric Research,
Год журнала:
2025,
Номер
185, С. 169 - 176
Опубликована: Март 29, 2025
Memory
function
impairment
is
severe
in
patients
with
schizophrenia,
but
improving
memory
remains
challenging.
The
use
of
benzodiazepines
and
anticholinergics,
which
are
not
recommended
by
pharmacological
therapy
guidelines
for
has
been
associated
worsened
cognitive
function.
However,
it
unclear
whether
better
adherence
psychiatrists
to
schizophrenia
improved
Therefore,
we
investigated
the
relationship
between
psychiatrists'
schizophrenia.
To
evaluate
associations
function,
utilized
Individual
Fitness
Score
(IFS),
includes
multiple
quality
indicators,
assess
each
psychiatrist's
these
treating
patient.
was
measured
using
Wechsler
Scale-Revised
a
total
351
patients,
including
40
treatment-resistant
(TRS)
311
non-TRS.
We
found
that
psychiatrist
significantly
positively
correlated
verbal
(β
=
0.145,
p
6.45
×
10-3),
attention/concentration
0.138,
0.010),
delayed
recall
0.167,
1.57
10-3)
all
Additionally,
nominal
positive
correlation
observed
visual
0.124,
0.019).
In
non-TRS
0.166,
3.17
nominally
0.141,
0.013)
0.114,
0.044)
functions.
contrast,
no
significant
were
any
functions
TRS.
These
findings
suggest
enhancing
guideline
education
might
improve
impairments
Язык: Английский
Associations between clozapine availability, the diagnosis of treatment-resistant schizophrenia subgroups, antipsychotic monotherapy, and concomitant psychotropics among patients with schizophrenia: a real-world nationwide study
The International Journal of Neuropsychopharmacology,
Год журнала:
2025,
Номер
28(4)
Опубликована: Март 28, 2025
The
rate
of
antipsychotic
polypharmacy
is
high.
One
risk
factor
for
may
be
the
severity
schizophrenia,
including
treatment-resistant
schizophrenia
(TRS).
We
hypothesized
that
institutions
are
able
to
prescribe
clozapine
present
differences
in
pharmacological
treatment
even
before
TRS
diagnosed.
A
total
8155
patients
with
were
divided
into
clozapine-available
institution
(CAI)
group
and
clozapine-unavailable
(CUI)
group.
psychotropic
prescription
rates
at
discharge
compared
between
two
groups.
Furthermore,
investigate
whether
diagnosis
subgroups
influenced
efficacy,
we
CAIs
CUIs
descriptions
(DSTRS)
those
without
(NDSTRS).
Compared
CUI
group,
both
monotherapy
(58.3%
vs.
50.7%;
p
=
2.4
×
10-7)
concomitant
use
other
psychotropics
(20.4%
15.6%;
3.8
10-5)
significantly
higher
CAI
DSTRS
(63.3%)
was
than
NDSTRS
(54.5%;
1.4
10-12),
(49.6%;
4.9
10-9),
(50.9%;
2.0
10-8).
(22.6%)
also
(18.7%;
4.7
10-4),
(15.9%;
5.5
(15.2%;
8.0
10-5).
There
no
significant
difference
these
Both
availability
prescriptions
precise
can
promote
development
an
organizational
culture
facilitates
schizophrenia.
Язык: Английский
Practice Guidelines for Bipolar Disorder by the JSMD (Japanese Society of Mood Disorders)
Psychiatry and Clinical Neurosciences,
Год журнала:
2024,
Номер
78(11), С. 633 - 645
Опубликована: Авг. 28, 2024
The
Japanese
Society
of
Mood
Disorders
(JSMD)
published
treatment
guidelines
bipolar
disorder
in
2011.
present
incorporating
new
findings
were
developed
to
comply
the
National
Academy
Medicine
(NAM)
by
utilizing
systematic
reviews
and
meta‐analysis
taking
patient
family
opinions
as
well
insights
from
multiple
professional
fields
into
account.
They
support
combination
therapy
using
mood
stabilizers
second‐generation
antipsychotics
many
aspects.
also
have
limitations,
including
grouping
when
was
performed
despite
their
distinct
properties,
due
scarcity
drug‐specific
evidence.
Despite
these
provide
clinical
decision
for
psychiatrists
Japan.
Язык: Английский
Effect of the guideline education program on anticholinergic and benzodiazepine use in outpatients with schizophrenia and major depressive disorder: The effectiveness of guidelines for dissemination and education in psychiatric treatment (EGUIDE) project
Psychiatry Research Communications,
Год журнала:
2024,
Номер
4(1), С. 100158 - 100158
Опубликована: Фев. 5, 2024
Reports
on
polypharmacy
strategies
for
patients
with
schizophrenia
and
major
depressive
disorder
(MDD)
are
scarce.
The
nationwide
Effectiveness
of
Guidelines
Dissemination
Education
in
Psychiatric
Treatment
(EGUIDE)
project
has
been
used
to
train
psychiatrists
the
guidelines
treatment
MDD.
This
study
aimed
determine
whether
EGUIDE
program
enabled
more
appropriate
evidence-based
outpatients
types
doses
all
psychotropics
were
analyzed
174
147
MDD,
respectively,
2018
before
2019
2020
after
program.
There
no
significant
differences
rate
monopharmacy
antipsychotics
schizophrenia;
however,
prescriptions
first-generation
antipsychotics,
anticholinergics,
benzodiazepines
decreased
significantly
also
antidepressant
rates
MDD;
MDD
Significant
positive
correlations
found
between
number
psychotropic
dosage
benzodiazepines.
In
conclusion,
improved
prescribing
behavior
depression.
Therefore,
guideline
training
may
be
useful
regulating
among
physicians.
Язык: Английский
The effect of education regarding treatment guidelines for schizophrenia and major depressive disorders on psychiatrists' hypnotic medication prescribing behavior: a multicenter study
BMC Psychiatry,
Год журнала:
2024,
Номер
24(1)
Опубликована: Май 29, 2024
To
examine
whether
the
"Effectiveness
of
Guideline
for
Dissemination
and
Education
in
psychiatric
treatment
(EGIUDE)"
project
affects
rate
prescriptions
hypnotic
medication
type
medications
prescribed
among
psychiatrists,
schizophrenia
major
depressive
disorder
Japan.
Язык: Английский
Integrating psychiatry into basic clinical skills: A three‐year nationwide quantitative assessment of postgraduate training programs
Psychiatry and Clinical Neurosciences Reports,
Год журнала:
2024,
Номер
3(4)
Опубликована: Сен. 25, 2024
Abstract
Aim
The
aim
of
this
study
was
to
develop
quantitative
outcome
indicators
for
psychiatric
training
programs
integrated
into
the
General
Medicine
In‐Training
Examination
(GM‐ITE)
and
investigate
which
characteristics
correlate
with
high
scores
in
psychiatry.
Methods
A
nationwide
cross‐sectional
conducted
over
3
fiscal
years
(2021–2023).
An
anonymous
online
questionnaire
distributed
postgraduate
year
1
2
residents
who
completed
GM‐ITE.
primary
GM‐ITE
score,
a
particular
focus
on
Multiple‐choice
questions
psychiatry
field
were
created
by
board‐certified
psychiatrists
various
subspecialties,
then
reviewed
piloted.
Multiple
regression
analysis
examined
correlations
between
score
resident
facility
characteristics.
Results
total
18,226
participated
years,
whom
5%–6%
aspired
specialize
Quantitative
effective
across
all
years.
Psychiatry
aspirants
had
lower
internal
medicine,
emergency,
but
higher
Residents
from
university
hospitals
scores,
while
number
beds
supervising
did
not
scores.
These
findings
indicate
need
distinct
general
medicine
emergency
training.
Conclusion
Based
these
highlights
necessity
improving
physical
assessment
skills
during
residency
aspirants,
Future
research
should
identify
practices
that
lead
among
residents,
thereby
better
integrate
basic
clinical
skills.
Язык: Английский
The association between benzodiazepine prescriptions and the risk of laxative use in schizophrenia treatment
Neuropsychopharmacology Reports,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 7, 2024
Constipation
is
one
of
the
most
common
adverse
effects
in
schizophrenia
treatment,
and
it
can
sometimes
cause
severe
gastrointestinal
disease.
However,
results
association
studies
between
constipation
psychotropic
medications
patients
with
are
inconsistent.
Therefore,
we
investigated
characteristics
laxative
prescriptions
at
discharge
to
clarify
psychotropics
constipation.
Язык: Английский
領域・職種を超えて取り組む抗不安薬の出口戦略
Anxiety Disorder Research,
Год журнала:
2023,
Номер
15(1), С. 20 - 30
Опубликована: Ноя. 30, 2023
ベンゾジアゼピン受容体作動薬(BZD)の抗不安薬は精神科・心療内科に限らず,広く一般診療科で処方されている。同薬剤の多剤併用・長期処方による依存形成のリスク,認知機能低下,転倒リスクの増大などが指摘されているが,実臨床においていったん多剤併用・長期処方に陥ると,身体依存により減薬は容易ではなく,長期処方から脱却できないケースも少なくない。そのため,我々は抗不安薬の出口戦略の実装化に向けて,令和3年度~4年度にかけて厚労科研研究「睡眠薬・抗不安薬の処方実態調査ならびに共同意思決定による適正使用・出口戦略のための研修プログラムの開発と効果検証研究」を実施した。本研究では多領域・多職種による取り組みにより臨床現場におけるBZDの実践的指針としてエキスパートコンセンサスの作成し,BZD適正使用・出口戦略の研修プログラムを開発することにより実装化を目指した。