Amygdala self-neuromodulation capacity as a window for process-related network recruitment

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2024, Номер 379(1915)

Опубликована: Окт. 21, 2024

Neurofeedback (NF) has emerged as a promising avenue for demonstrating process-related neuroplasticity, enabling self-regulation of brain function. NF targeting the amygdala drawn attention to therapeutic potential in psychiatry, by potentially harnessing emotion-regulation processes. However, not all individuals respond equally training, possibly owing varying abilities. This underscores importance understanding mechanisms behind successful neuromodulation (i.e. capacity). study aimed investigate establishment and neural correlates capacity using data from repeated sessions electrical fingerprint (Amyg-EFP)-NF post-training functional magnetic resonance imaging (fMRI)-NF sessions. Results 97 participants (healthy controls post-traumatic stress disorder fibromyalgia patients) revealed increased Amyg-EFP over associated with amygdala-fMRI modulation improvements alexithymia. Individual differenaces this were pre-training reactivity initial success. Additionally, downregulation during fMRI-NF co-modulated other regions such posterior insula parahippocampal gyrus. combined better explained EFP-modulation improvement alexithymia than alone, suggesting relevance broader network gained capacity. These findings support network-based approach highlight need consider individual differences function optimize interventions. article is part theme issue ‘Neurofeedback: new territories neurocognitive endogenous neuromodulation’.

Язык: Английский

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Systematic review and meta-analysis of neurofeedback and its effect on posttraumatic stress disorder

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Март 21, 2024

Background To date, only one systematic review and meta-analysis of randomized controlled trials (RCTs) has evaluated the effect neurofeedback in PTSD, which included four studies found an uncertainty EEG-NF on PTSD symptoms. This is update considering that numerous have since been published. Additionally, more recent fMRI-NF as well fMRI-guided or -inspired EEG NF Methods Systematic literature searches for RCTs were conducted three online databases. Additional hand each study identified reviews meta-analyses published also undertaken. Outcomes vs. a control (active, sham, waiting list) their effects reducing symptoms using various health instruments. Meta-analytical methods used inverse variance random-effects models measuring both mean standardized differences. Quality certainty evidence assessed GRADE. Adverse events evaluated. Results A total 17 evaluating 628 patients. There 10 meta-analysis. from all favored neurofeedback’s including BDI pretest–posttest [mean difference (MD): 8.30 (95% CI: 3.09 to 13.52; P = 0.002; I 2 0%)]; pretest–follow-up (MD: 8.75 3.53 13.97; < 0.00001; 0%); CAPS-5 [MD: 7.01 1.36 12.66; 0.02; 86%)]; 1.29 21.29; 0.006; 77%); PCL-5 7.14 3.08 11.2; 0.0006; 14.95 7.95 21.96; 0.0001; 0%). Other reported improvements other GRADE assessments CAPS, PCL, demonstrated moderate/high level quality positive clinical effect. Conclusion Based newer outcomes measured, clinically meaningful size, with increased size at follow-up. appears be driven by deeper brain derivates it.

Язык: Английский

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Amygdala EFP Neurofeedback Effects on PTSD Symptom Clusters and Emotional Regulation Processes

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2421 - 2421

Опубликована: Апрель 2, 2025

Background: Post-traumatic stress disorder (PTSD) manifests through distinct symptom clusters that can respond differently to treatments. Neurofeedback guided by the Amygdala-derived-EEG-fMRI-Pattern (Amyg-EFP-NF) has been utilized train PTSD patients regulate amygdala-related activity and decrease symptoms. Methods: We conducted a combined analysis of 128 from three clinical trials Amyg-EFP-NF evaluate effects across (as assessed CAPS-5 subscales) on emotion regulation processing (evaluated ERQ). Results: significantly reduced severity all immediately post-treatment, with improvements maintained at three-month follow-up. The arousal reactivity cluster showed continued significant improvement during Combined effect sizes were large (η2p = 0.23-0.35) clusters. Regression revealed processes explained 17% variance in follow-up period. Conclusions: Reduction symptoms following occurs clusters, emotional potentially serving as an underlying mechanism action. These results support comprehensive treatment approach for continues show benefits after completion.

Язык: Английский

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Reward System EEG–fMRI-Pattern Neurofeedback for Major Depressive Disorder with Anhedonia: A Multicenter Pilot Study

Brain Sciences, Год журнала: 2025, Номер 15(5), С. 476 - 476

Опубликована: Апрель 29, 2025

Background/Objectives: Up to 75% of patients with major depressive disorder (MDD) exhibit persistent anhedonia symptoms related abnormalities in the positive valence system. Cumulative evidence points brain dysfunction reward system (RS), including ventral striatum, MDD anhedonia. This study aims evaluate safety and efficacy a novel neurofeedback (NF) device (termed Prism) which incorporates EEG-FRI-Pattern biomarker (RS-EFP) for use self-neuromodulation training (RS-EFP-NF) alleviating depression Methods: A total 49 adults (age range: M = 39.9 ± 11.03) DSM-5 diagnosis (per SHAPS-C score ≥ 25) were screened administration ten sessions RS-EFP-NF twice week on nonconsecutive days. Depression severity was assessed, respectively, by HDRS-17 at baseline, midway, treatment end. Results: 34 (77%) completed protocol included analyses. No device-related adverse events serious or required treatment. reduced end as indicated HDRS-17, reduction eight average (95% CI: -10.5 -5.41, p < 0.0001), clinical improvement rate 78.47%, remission 32.25%. Anhedonia, score, diminished, showing an 6.3 -8.51 -4.14, 0.0001). Conclusions: Self-neuromodulation using is promising safe The intervention demonstrates substantial effects both symptoms, high patient acceptability retention. Prism may address critical mechanism-driven gap that often persists despite conventional therapies. Larger controlled implementation, efficacy, dosing studies are warranted.

Язык: Английский

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The Lack of Neurofeedback Training Regulation Guidance and Process Evaluation May be a Source of Controversy in Post-Traumatic Stress Disorder–Neurofeedback Research: A Systematic Review and Statistical Analysis

Brain Connectivity, Год журнала: 2025, Номер unknown

Опубликована: Май 15, 2025

Objectives: Neurofeedback (NF) based on brain-computer interface (BCI) is an important direction in adjunctive interventions for post-traumatic stress disorder (PTSD). However, existing research lacks comprehensive methodologies and experimental designs. There are concerns the field regarding effectiveness mechanistic interpretability of NF, prompting this study to conduct a systematic analysis primary NF techniques outcomes PTSD modulation. The aims explore reasons behind these propose directions addressing them. Methods: A search conducted Web Science database up December 1, 2023, yielded 111 English articles, which 80 were excluded predetermined criteria irrelevant study. remaining 31 original studies included literature review. checklist was developed assess robustness credibility studies. Subsequently, classified into electroencephalogram-based (EEG-NF) functional magnetic resonance imaging-based (fMRI-NF) BCI type. Data target brain regions, signals, modulation protocols, control group types, assessment methods, data processing strategies, reported extracted synthesized. Consensus theories from future improvements related distilled. Results: Analysis all revealed that average sample size patients EEG fMRI 17.4 (SD 7.13) 14.6 6.37), respectively. Due neurofeedback training protocol constraints, 93% EEG-NF 87.5% fMRI-NF used traditional statistical with minimal utilization basic machine learning (ML) methods no utilizing deep (DL) methods. Apart approximately 25% supporting exploratory psychoregulatory lacked explicit guidance. Only 13% evaluated involving signal classification, decoding during process, lacking process monitoring means. Conclusion: In summary, holds promise as intervention technique PTSD, potentially aiding symptom alleviation patients. necessary evaluation mechanisms PTSD-NF, clarity guidance, development ML/DL suitable PTSD-NF small sizes. To address challenges, it crucial adopt more rigorous should focus integration advanced enhance precision interventions. Impact Statement implications limited application (NFT) (PTSD) research, where significant portion approaches, foundational conclusions lack consensus. notable absence retrospective analyses NFT PTSD. This provides discussion offering valuable insights findings hold significance researchers, clinicians, practitioners field, providing foundation informed, evidence-based treatment.

Язык: Английский

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Novel Pharmacologic and Other Somatic Treatment Approaches for Posttraumatic Stress Disorder in Adults: State of the Evidence

American Journal of Psychiatry, Год журнала: 2024, Номер 181(12), С. 1045 - 1058

Опубликована: Дек. 1, 2024

Posttraumatic stress disorder (PTSD) is a highly prevalent psychiatric that can become chronic and debilitating when left untreated. The most commonly recommended first-line treatments for PTSD among adults are individual trauma-focused psychotherapies. Other evidence-based include specific antidepressant medications non-trauma-focused Despite the effectiveness of these available treatments, many patients' symptoms do not remit. This has led to search novel PTSD. In this review, authors critically evaluate data supporting several emerging pharmacological other somatic interventions in categories medication-assisted psychotherapy, medication monotherapy strategies, neuromodulation, selected because salience their mechanisms action pathophysiology (e.g., MDMA-assisted ketamine, cannabidiol, transcranial magnetic stimulation). also evidence focus increasing scientific or public interest (i.e., hyperbaric oxygen therapy, stellate ganglion block, neurofeedback). To date, preliminary variable; however, such as stimulation, encouraging.

Язык: Английский

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Amygdala Self-Neuromodulation Capacity as a Window for Process-Related Network Recruitment

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 8, 2024

Abstract Neurofeedback (NF) has emerged as a promising avenue for demonstrating process-related neuroplasticity, enabling self-regulation of brain function. NF targeting the amygdala drawn attention therapeutic potential in psychiatry, by potentially harnessing emotion-regulation processes. However, not all individuals respond equally to training, possibly due varying abilities. This underscores importance understanding mechanisms behind successful neuromodulation (i.e. capacity). study aimed investigate establishment and neural correlates capacity using data from repeated sessions Amygdala Electrical Finger Print (EFP)-NF post-training fMRI-NF session. Results 97 psychiatric patients healthy participants revealed increased amygdala-EFP over associated with fMRI modulation-capacity improvements alexithymia. Individual differences this were pre-training reactivity initial success. Additionally, down-regulation during co-modulated other regions such posterior-insula parahippocampal gyrus. combined modulation better explained EFP-modulation improvement alexithymia than alone, suggesting relevance broader network gained capacity. These findings support network-based approach highlight need consider individual function optimize interventions.

Язык: Английский

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Advancing posttraumatic stress disorder treatment: A novel approach in treatment‐resistant childhood sexual abuse posttraumatic stress disorder

Psychiatry and Clinical Neurosciences, Год журнала: 2024, Номер 78(1), С. 1 - 1

Опубликована: Янв. 1, 2024

Язык: Английский

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