Transcranial Direct Current Stimulation (tDCS) for Borderline Personality Disorder (BPD): Why and How? DOI Creative Commons
Lionel Cailhol,

Kamilia Soltani,

Cécilia Neige

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(6), С. 547 - 547

Опубликована: Май 23, 2025

Background: Borderline Personality Disorder (BPD) is a severe psychiatric condition characterized by pervasive emotional dysregulation, impulsivity, and unstable interpersonal relationships. Affecting over 1% of the general population, BPD carries significant morbidity, frequent hospitalizations, an increased risk suicide. Although specialized psychotherapeutic approaches have shown efficacy, their impact often constrained availability, lengthy treatment durations, moderate effect sizes, high dropout rates. Pharmacological treatments for remain inadequate are usually accompanied adverse side effects. Objective: This narrative review seeks to explore potential transcranial direct current stimulation (tDCS) as safe, cost-effective, accessible neuromodulation intervention aimed at alleviating core symptoms—namely, dysregulation impulsivity—while also addressing common comorbidities opportunities integration with existing therapeutic modalities. Methods: We conducted literature synthesis in accordance SANRA (Scale Assessment Narrative Review Articles) guidelines. A PubMed/MEDLINE search was performed using keywords related BPD, identifying five published randomized controlled trials on topic. To provide broader perspective, we included studies from fields examining mechanisms action, safety tolerability, cost-effectiveness, parameters, clinical outcomes relevant BPD. Results: Conventional tDCS protocols—typically involving 1–2 mA currents 20–30 min—have demonstrated excellent profile, resulting only minimal transient effects without any overdose or misuse, which key advantage populations suicidality. With moderately priced devices feasibility home-based administration, provides substantially more affordable alternative both long-term pharmacotherapy intensive psychotherapy. Neurobiologically, modulates excitability dorsolateral ventrolateral prefrontal cortex enhances fronto-limbic connectivity, thereby strengthening top-down regulatory control emotion behavior. Pilot report sizes improvements regulation, inhibitory control, rejection sensitivity, along ancillary gains executive functioning reductions depressive substance-use symptoms when stimulating left cortex. Conclusions: emerges safe scalable adjunctive leveraging targeted address features like depression. However, variability protocols scarcity well-powered underscore pressing need standardized methodologies, longer-term follow-up, individualized strategies establish enduring benefits.

Язык: Английский

Longitudinal Effects of Transcranial Direct Current Stimulation on Daily Rejection-Related Emotions in Borderline Personality Disorder: An Ecological Momentary Assessment Study Protocol DOI Creative Commons
Chiara De Panfilis,

Alessandro Lisco,

Kevin B. Meehan

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(5), С. 530 - 530

Опубликована: Май 20, 2025

Background: Borderline Personality Disorder (BPD) is a debilitating mental health condition characterized by emotional dysregulation and interpersonal dysfunction, with perceived social rejection exacerbating these issues. Emerging evidence suggests that single session of transcranial direct current stimulation (tDCS) over the right ventrolateral prefrontal cortex (rVLPFC) may decrease unique tendency BPD patients to feel rejected even when socially included during laboratory task. Objectives: This protocol outlines double-blind, sham-controlled study evaluating longitudinal effects repeated anodal tDCS on rejection-related emotions (RRE) real-life interactions in individuals BPD. Methods: Sixty will be randomized receive real or sham across 10 daily sessions, coupled an ecological momentary assessment (EMA) capturing behavioral responses four timepoints: baseline, treatment, ten days post-treatment, three months post-treatment. Primary outcomes include changes RRE, exploratory analyses examining feelings connection, aggressive tendencies, trust toward others, affective dynamics. Multilevel modeling assess temporal group-level effects. Expected Results Impact: aims establish efficacy reducing patients’ negative response situations determine whether such are maintained time. The findings could advance clinical application as adjunctive intervention alleviate social–emotional impairments BPD, addressing gaps treatment approaches guiding future research into neural mechanisms emotion regulation.

Язык: Английский

Процитировано

0
Understanding borderline personality disorder: Clinical features, neurobiological insights, and therapeutic strategies DOI

Surendar Ellappan,

Rhea Subba, Amal Chandra Mondal

и другие.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер 139, С. 111403 - 111403

Опубликована: Май 20, 2025

Язык: Английский

Процитировано

0
Transcranial Direct Current Stimulation (tDCS) for Borderline Personality Disorder (BPD): Why and How? DOI Creative Commons
Lionel Cailhol,

Kamilia Soltani,

Cécilia Neige

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(6), С. 547 - 547

Опубликована: Май 23, 2025

Background: Borderline Personality Disorder (BPD) is a severe psychiatric condition characterized by pervasive emotional dysregulation, impulsivity, and unstable interpersonal relationships. Affecting over 1% of the general population, BPD carries significant morbidity, frequent hospitalizations, an increased risk suicide. Although specialized psychotherapeutic approaches have shown efficacy, their impact often constrained availability, lengthy treatment durations, moderate effect sizes, high dropout rates. Pharmacological treatments for remain inadequate are usually accompanied adverse side effects. Objective: This narrative review seeks to explore potential transcranial direct current stimulation (tDCS) as safe, cost-effective, accessible neuromodulation intervention aimed at alleviating core symptoms—namely, dysregulation impulsivity—while also addressing common comorbidities opportunities integration with existing therapeutic modalities. Methods: We conducted literature synthesis in accordance SANRA (Scale Assessment Narrative Review Articles) guidelines. A PubMed/MEDLINE search was performed using keywords related BPD, identifying five published randomized controlled trials on topic. To provide broader perspective, we included studies from fields examining mechanisms action, safety tolerability, cost-effectiveness, parameters, clinical outcomes relevant BPD. Results: Conventional tDCS protocols—typically involving 1–2 mA currents 20–30 min—have demonstrated excellent profile, resulting only minimal transient effects without any overdose or misuse, which key advantage populations suicidality. With moderately priced devices feasibility home-based administration, provides substantially more affordable alternative both long-term pharmacotherapy intensive psychotherapy. Neurobiologically, modulates excitability dorsolateral ventrolateral prefrontal cortex enhances fronto-limbic connectivity, thereby strengthening top-down regulatory control emotion behavior. Pilot report sizes improvements regulation, inhibitory control, rejection sensitivity, along ancillary gains executive functioning reductions depressive substance-use symptoms when stimulating left cortex. Conclusions: emerges safe scalable adjunctive leveraging targeted address features like depression. However, variability protocols scarcity well-powered underscore pressing need standardized methodologies, longer-term follow-up, individualized strategies establish enduring benefits.

Язык: Английский

Процитировано

0