Immunosuppressive Therapy, Puberty and Growth Outcomes in Pediatric Kidney Transplant Recipients: A Pragmatic Review DOI Creative Commons

Mariateresa Zicarelli,

Antonietta Errante,

Michele Andreucci

и другие.

Pediatric Transplantation, Год журнала: 2024, Номер 28(7)

Опубликована: Окт. 24, 2024

ABSTRACT Kidney transplantation in children with end‐stage kidney disease significantly enhances survival and quality of life but poses unique challenges related to chronic immunosuppressive therapy. In fact, despite being essential for preventing organ rejection, therapy can have significant side effects specific pediatric patients, such as adverse impacts on physiological growth, puberty, fertility. The resulting short stature delayed or incomplete pubertal development profoundly affect young patients' psychological social well‐being, impacting self‐esteem overall life, may hamper compliance therapeutic adherence. Most studies immunosuppression transplant recipients focus general outcomes like long‐term graft acute complications. On the other side, there is limited evidence current literature issues fertility this patient population. pragmatic review, we aimed summarize most relevant information available these critical aspects post‐transplant management also providing some practical indications strategies minimizing often neglected still important

Язык: Английский

Immunosuppressive Therapy, Puberty and Growth Outcomes in Pediatric Kidney Transplant Recipients: A Pragmatic Review DOI Creative Commons

Mariateresa Zicarelli,

Antonietta Errante,

Michele Andreucci

и другие.

Pediatric Transplantation, Год журнала: 2024, Номер 28(7)

Опубликована: Окт. 24, 2024

ABSTRACT Kidney transplantation in children with end‐stage kidney disease significantly enhances survival and quality of life but poses unique challenges related to chronic immunosuppressive therapy. In fact, despite being essential for preventing organ rejection, therapy can have significant side effects specific pediatric patients, such as adverse impacts on physiological growth, puberty, fertility. The resulting short stature delayed or incomplete pubertal development profoundly affect young patients' psychological social well‐being, impacting self‐esteem overall life, may hamper compliance therapeutic adherence. Most studies immunosuppression transplant recipients focus general outcomes like long‐term graft acute complications. On the other side, there is limited evidence current literature issues fertility this patient population. pragmatic review, we aimed summarize most relevant information available these critical aspects post‐transplant management also providing some practical indications strategies minimizing often neglected still important

Язык: Английский

Процитировано

0