Pathological evaluation of the pathogenesis of diabetes mellitus and diabetic peripheral neuropathy

Pathology International, Год журнала: 2024, Номер 74(8), С. 438 - 453

Опубликована: Июнь 18, 2024

Currently, there are more than 10 million patients with diabetes mellitus in Japan. Therefore, the need to explore pathogenesis of and complications leading its cure is becoming increasingly urgent. Pathological examination pancreatic tissues from type 2 reveals a decrease volume beta cells because combination various stresses. In human diabetes, islet amyloid deposition unique pathological change characterized by proinflammatory macrophage (M1) infiltration into islets. The changes pancreas were different according clinical factors, which suggests that can be further subclassified based on pathology. On other hand, diabetic peripheral neuropathy most frequent complication. early neuropathy, M1 sciatic nerve evokes oxidative stress or attenuates retrograde axonal transport, as clearly demonstrated vitro live imaging. Furthermore, parasympathetic density cell inversely correlated Goto-Kakizaki rats, suggesting itself may contribute volume. These findings suggest interrelated.

Язык: Английский

Questioning the pros and cons of metformin treatment in diabetic peripheral neuropathy

Journal of Diabetes Investigation, Год журнала: 2025, Номер unknown

Опубликована: Апрель 25, 2025

Язык: Английский

Ribonuclease 4 is a pancreatic endogenous β cell proliferation factor

Science Bulletin, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский